4,5-diethyl-1,3-dioxolane | 676610-04-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氧戊环
• 英文名称: 4,5-diethyl-1,3-dioxolane
• 英文别名: 4,5-diethyl-1,3-dioxolan
• CAS: 676610-04-1
• 化学式: C₇H₁₄O₂
• 分子量: 130.187
• InChiKey: UNJKRLGRDWZYOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3,4-己二醇 、 二氧化碳 在 [Ru(1,1,1-tris(diphenylphosphinomethyl)ethane)(trimethylenemethane)] 、 氢气 、 双三氟甲烷磺酰亚胺 作用下， 生成 4,5-diethyl-1,3-dioxolane
  参考文献：
  名称：

  通过合适的溶剂切换实现的顺序生物催化和化学催化有效生产选定的二氧戊环

  摘要：

  成功的组合：生物催化和化学催化的结合是获取复杂（手性）分子的有效方法。在这里，两步酶促级联在相同的有机溶剂中与钌催化的化学转化相结合，从脂肪醛形成二氧戊环。结合两个世界的方法可以很容易地应用于其他混合系统。

  DOI：

  10.1002/cssc.202201981

文献信息

• CYCLOALKYLPHENYL SUBSTITUTED CYCLIC KETOENOLS
  申请人：Fischer Reiner

  公开号：US20090305891A1

  公开（公告）日：2009-12-10

  The disclosure relates to novel cycloalkylphenyl-substituted cyclic ketoenols of the formula (I) in which J, X, Y, m and CKE are as defined above, to processes and intermediates for their preparation and to their use as pesticides and/or herbicides. Moreover, the disclosure relates to selective herbicidal compositions comprising, firstly, the cycloalkylphenyl-substituted cyclic ketoenols and, secondly, a crop plant compatibility-improving compound. The disclosure furthermore relates to increasing the activity of crop protection compositions comprising compounds of the formula (I) by adding ammonium or phosphonium salts and, if appropriate, penetrants.

  该披露涉及到具有以下结构的新型环烷基苯基取代的环状酮烯醇（I）的公式，其中J、X、Y、m和CKE的定义如上所述，以及它们的制备过程和中间体，以及它们作为杀虫剂和/或除草剂的用途。此外，该披露涉及包括第一部分为环烷基苯基取代的环状酮烯醇和第二部分为作物植物相容性改进化合物的选择性除草剂组合物。该披露还涉及通过添加铵盐或膦盐以及必要时渗透剂来增加公式（I）化合物的作物保护组合物的活性。
• SUBSTITUTED CYCLOALKENE DERIVATIVE
  申请人：Kimura Tomio

  公开号：US20090233952A1

  公开（公告）日：2009-09-17

  [Object] To provide a substituted cycloalkene derivative having an action to suppress intracellular signal transduction or cell activation induced by endotoxin and to suppress cell responses due to the intracellular signal transduction and cell activation such as an excess generation of inflammatory mediators such as TNF-α, pharmacologically acceptable salts therefor, a medicament containing them as an active ingredient, a preparation method therefor, and a medicament containing the aforementioned substituted cycloalkene derivative as an active ingredient which is superior in prophylaxis and/or treatment of diseases such as sepsis (septic shock, disseminated intravascular coagulation, multiple organ failure and the like), that are associated with intracellular signal transduction or cell activation induced by endotoxin and to cell responses to the intracellular signal transduction and cell activation. [Solution] A compound represented by the general formula (I): wherein X and Y represent a group in which X and Y together with a carbon atom to which they are bound form ring A (the ring is 3- to 7-membered heterocyclyl ring or 3- to 7-membered cycloalkyl ring), each represents a hydrogen atom, or X and Y together represent a substituent of ring B. l and m, independently from each other, represent an integer of 0 to 3, and l+m is 1 to 3. R 1 is an aliphatic hydrocarbon group and the like which may be substituted with a group selected from Substituent group β and Substituent group γ. n represents an integer of 0 to 3. R 2 is a C 1 -C 6 alkyl group and the like which may be substituted with a group selected from a hydrogen atom and Substituent group β. R 3 is a phenyl group, 5- to 6-membered heteroaryl group and the like which may be substituted with a group selected from Substituent group ε. R 5 is a C 1 -C 6 alkyl group and the like which may be substituted with a group selected from a hydrogen atom and Substituent group β. Provided that in the case where R 3 is a phenyl group which may be substituted with a group selected from Substituent group ε, X and Y represent a group in which X and Y together with a carbon atom to which they are bound form ring A, or X and Y together represent a substituent of ring B.

  [目的] 提供一种替代环烯烃衍生物，具有抑制内毒素诱导的细胞内信号传导或细胞活化并抑制细胞对细胞内信号传导和细胞活化的反应，例如过量生成TNF-α等炎症介质，其药理学上可接受的盐，包含其作为活性成分的药物，其制备方法以及含有上述替代环烯烃衍生物作为活性成分的药物，其在预防和/或治疗与内毒素诱导的细胞内信号传导或细胞活化以及对细胞内信号传导和细胞活化的反应有关的疾病，例如败血症（败血性休克，弥漫性血管内凝血，多器官衰竭等）方面具有优越性。 [解决方案] 一种由通式（I）表示的化合物：其中，X和Y表示与它们结合的碳原子形成环A（环为3-至7成员的杂环或3-至7成员的环烷基环）的基团，每个表示氢原子，或X和Y一起表示环B的取代基。l和m，独立地，表示0至3的整数，且l+m为1至3。R1是脂肪烃基等，可以被从取代基组β和取代基组γ中选择的基团取代。n表示0至3的整数。R2是C1-C6烷基等，可以被从氢原子和取代基组β中选择的基团取代。R3是苯基，5-至6成员的杂环基等，可以被从取代基组ε中选择的基团取代。R5是C1-C6烷基等，可以被从氢原子和取代基组β中选择的基团取代。但在R3是苯基且可以被从取代基组ε中选择的基团取代的情况下，X和Y表示与它们结合的碳原子形成环A的基团，或X和Y一起表示环B的取代基。
• KINASE INHIBITORS
  申请人：Dong Qing

  公开号：US20090247554A1

  公开（公告）日：2009-10-01

  Compounds are provided for use with kinases that comprise (I), (II), (III), (IV): wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

  提供了与包含(I)、(II)、(III)、(IV)的激酶一起使用的化合物：其中变量如本文所定义。还提供了包括这些化合物的药物组合物、工具包和制造物品；用于制备这些化合物的方法和中间体；以及使用这些化合物的方法。
• UREA TYPE CINNAMIDE DERIVATIVE
  申请人：Kimura Teiji

  公开号：US20100105904A1

  公开（公告）日：2010-04-29

  Disclosed is a compound represented by the formula (I) below or a pharmacologically acceptable salt thereof. Also disclosed is a use of the compound or salt as a pharmaceutical product. (In the formula, Ar 1 represents an imidazolyl group which may be substituted with a C 1-6 alkyl group; Ar 2 represents a phenyl group which may be substituted with a C 1-6 alkoxy group; X 1 represents a single bond; R 1 and R 2 respectively represent a C 1-6 alkyl group or the like which may be substituted with a substituent such as a 5- to 14-membered aromatic heterocyclic group; and R 3 represents a hydrogen atom or the like.)

  本发明涉及一种由下式（I）表示的化合物或其药学上可接受的盐。本发明还涉及该化合物或盐作为制药产品的用途。（在公式中，Ar1代表可以被C1-6烷基取代的咪唑基；Ar2代表可以被C1-6烷氧基取代的苯基；X1代表单键；R1和R2分别代表C1-6烷基或类似物，可以被5-至14-成员芳香杂环基等取代基取代；而R3代表氢原子或类似物。）
• COMPOUND
  申请人：KIMURA Teiji

  公开号：US20110086860A1

  公开（公告）日：2011-04-14

  A compound represented by Formula (I) is provided: wherein Ar 1 represents an imidazolyl group which may be substituted with 1 to 3 substituents; Ar 2 represents a phenyl group which may be substituted with 1 to 3 substituents; X 1 represents (1) —C≡C— or (2) a double bond etc., which may be substituted; R 1 and R 2 represent, for example, a C1-6 alkyl group which may be substituted, or a pharmacologically acceptable salt thereof and to the use thereof as pharmaceutical agents.

  提供一种由式（I）表示的化合物： 其中Ar1代表一种咪唑基团，该基团可以被1到3个取代基取代；Ar2代表一种苯基团，该基团可以被1到3个取代基取代；X1代表（1）—C≡C—或（2）一个双键等，该双键可以被取代；R1和R2代表例如可以被取代的C1-6烷基或其药物学上可接受的盐，以及其作为制药剂的用途。