[2,3'-联吡啶]-3-羧酸 | 851368-00-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: [2,3'-联吡啶]-3-羧酸
• 英文名称: 2,3'-bipyridyl-3-carboxylic acid
• 英文别名: [2,3']bipyridyl-3-carboxylic acid；[2,3']Bipyridyl-3-carbonsaeure；2,3'-bipyridine-3-carboxylic acid；[2,3'-Bipyridine]-3-carboxylic acid；2-pyridin-3-ylpyridine-3-carboxylic acid
• CAS: 851368-00-8
• 化学式: C₁₁H₈N₂O₂
• 分子量: 200.197
• InChiKey: VMOKBNOWCJXTND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  [2,3'-联吡啶]-3-羧酸 在 氯化亚砜 作用下， 生成 3-(Methoxycarbonyl)-2,3'-bipyridine
  参考文献：
  名称：

  Lukes; Pliml, Collection of Czechoslovak Chemical Communications, 1956, vol. 21, p. 632,635

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 生成 [2,3'-联吡啶]-3-羧酸
  参考文献：
  名称：

  Skraup; Vortmann, Monatshefte fur Chemie, 1882, vol. 3, p. 599

  摘要：

  DOI：

文献信息

• [EN] COMPOUNDS, COMPOSITIONS, AND METHODS OF USE<br/>[FR] COMPOSÉS, COMPOSITIONS ET PROCÉDÉS D'UTILISATION
  申请人：SAGE THERAPEUTICS INC

  公开号：WO2020243027A1

  公开（公告）日：2020-12-03

  Described herein are compounds that act as CYP46A1 inhibitors, compositions comprising these compounds, and methods of their use into treating neurodegenerative diseases and the like, or a pharmaceutically active salt thereof. The present invention relates to compounds represented by the formula wherein each symbol is as defined in the specification, or a pharmaceutically active salt thereof.

  本发明涉及作为CYP46A1抑制剂的化合物，包括这些化合物的组合物，以及它们用于治疗神经退行性疾病等方法，或其药用活性盐。本发明的化合物由以下公式表示，其中每个符号如说明书中所定义，或其药用活性盐。
• Materials and methods for inhibiting fouling of surfaces exposed to aquatic environments
  申请人：——

  公开号：US20040235901A1

  公开（公告）日：2004-11-25

  The subject invention provides materials and methods for inhibiting the biofouling of surfaces exposed to aquatic environments. In one embodiment, the subject invention provides additives for marine paints and surface treatments. The subject invention further provides repellants and selective inhibitors for aquatic and/or terrestrial crustacean pests.

  本主题发明提供了用于抑制暴露在水生环境中的表面生物污垢的材料和方法。在一个实施例中，本主题发明提供了用于海洋涂料和表面处理的添加剂。本主题发明还提供了用于水生和/或陆生甲壳动物害虫的驱避剂和选择性抑制剂。
• Synthesis and Spectroscopic Comparison of the Eight Methyl-2,3’-bipyridyls and Identification of a Hoplonemertine Alkaloid as 3-Methyl-2,3’-bipyridyl
  作者：William R. Kem、H. Martin Garraffo、Thomas F. Spande、John W. Daly、Ferenc Sóti、James Rocca

  DOI：10.3987/com-08-s(d)80

  日期：——

  The pyridyl ring is frequently found in natural products and drugs. While bipyridyls have served as useful scaffolds for development of industrial and pesticidal chemicals, their biological properties are still not well understood. Only 2,3'-bipyridyl, of the six isomeric bipyridyls, has been reported as a natural product in tobacco plants and in a hoplonemertine marine worm, Amphiporus angulatus (Aa), which uses its pyridyl alkaloid-rich venom to paralyze its crustacean prey and chemically defend itself against predators. Here we report for the first time the synthesis and spectroscopic properties of all eight possible methyl 2,3'-bipyridyl isomers and use this data to identify a trace alkaloidal constituent of Aa as 3-methyl-2,3'-bipyridyl. This is only the second reported instance of a methyl-bipyridyl being found as a natural product, the first being the tobacco alkaloid 5-methyl-2,3'-bipyridyl.
• SKRAUP'S REACTION APPLIED TO THE PHENYLENEDIAMINES. PREPARATION OF THE PHENANTHROLINES AND RELATED DIPYRIDYLS
  作者：C. R. Smith

  DOI：10.1021/ja01364a061

  日期：1930.1
• Skraup; Vortmann, Monatshefte fur Chemie, 1882, vol. 3, p. 599
  作者：Skraup、Vortmann

  DOI：——

  日期：——