[2,6-双(4-甲氧基-2-甲基苯基)吡啶-4-基]甲醇 | 816446-65-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: [2,6-双(4-甲氧基-2-甲基苯基)吡啶-4-基]甲醇
• 英文名称: [2,6-Bis-(4-methoxy-2-methyl-phenyl)-pyridin-4-yl]-methanol
• 英文别名: [2,6-Bis(4-methoxy-2-methylphenyl)pyridin-4-yl]methanol；[2,6-bis(4-methoxy-2-methylphenyl)pyridin-4-yl]methanol
• CAS: 816446-65-8
• 化学式: C₂₂H₂₃NO₃
• 分子量: 349.43
• InChiKey: KUQUVKPPRWEUBX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  51.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  [2,6-双(4-甲氧基-2-甲基苯基)吡啶-4-基]甲醇 在 草酰氯 、 potassium tert-butylate 、 二甲基亚砜 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 0.17h， 生成 (E)-3-[2,6-Bis-(4-methoxy-2-methyl-phenyl)-pyridin-4-yl]-acrylic acid ethyl ester
  参考文献：
  名称：

  Structural studies of biarylpyridines fluorophores lead to the identification of promising long wavelength emitters for use in fluorescent chemosensors

  摘要：

  Fluorescent chemosensors-molecules whose fluorescence emission changes in response to a reversible binding event-require both a substrate binding domain and a reporting fluorophore. Our approach to chemosensor development is based on a combination of a new signaling mechanism and a modular fluorophore synthesis. The latter feature has facilitated detailed study of the properties of polyarylpyridine fluorophores, and has led to the identification of a visibly-emissive pyridine as a promising lead structure for chemosensor development. The results of this study are described herein. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.08.049
• 作为产物：
  描述：

  Methyl 2,6-bis(4-methoxy-2-methylphenyl)pyridine-4-carboxylate 在 二异丁基氢化铝 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 以89%的产率得到[2,6-双(4-甲氧基-2-甲基苯基)吡啶-4-基]甲醇
  参考文献：
  名称：

  Structural studies of biarylpyridines fluorophores lead to the identification of promising long wavelength emitters for use in fluorescent chemosensors

  摘要：

  Fluorescent chemosensors-molecules whose fluorescence emission changes in response to a reversible binding event-require both a substrate binding domain and a reporting fluorophore. Our approach to chemosensor development is based on a combination of a new signaling mechanism and a modular fluorophore synthesis. The latter feature has facilitated detailed study of the properties of polyarylpyridine fluorophores, and has led to the identification of a visibly-emissive pyridine as a promising lead structure for chemosensor development. The results of this study are described herein. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.08.049

文献信息

• Structural studies of biarylpyridines fluorophores lead to the identification of promising long wavelength emitters for use in fluorescent chemosensors
  作者：A.G. Fang、J.V. Mello、N.S. Finney

  DOI：10.1016/j.tet.2004.08.049

  日期：2004.11

  Fluorescent chemosensors-molecules whose fluorescence emission changes in response to a reversible binding event-require both a substrate binding domain and a reporting fluorophore. Our approach to chemosensor development is based on a combination of a new signaling mechanism and a modular fluorophore synthesis. The latter feature has facilitated detailed study of the properties of polyarylpyridine fluorophores, and has led to the identification of a visibly-emissive pyridine as a promising lead structure for chemosensor development. The results of this study are described herein. (C) 2004 Elsevier Ltd. All rights reserved.