[(4Z)-4-benzylidene-5-oxo-2-phenyl-imidazol-1-yl] acetate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: [(4Z)-4-benzylidene-5-oxo-2-phenyl-imidazol-1-yl] acetate
• 英文别名: [(4Z)-4-benzylidene-5-oxo-2-phenylimidazol-1-yl] acetate
• 化学式: C₁₈H₁₄N₂O₃
• 分子量: 306.321
• InChiKey: ZZEZCTHRXOIBNR-VBKFSLOCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  59
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (4Z)-4-benzylidene-2-phenyl-1,3-oxazol-5(4H)-one 在 羟胺 、 potassium carbonate 、 三乙胺 作用下， 以 乙醇 为溶剂， 生成 [(4Z)-4-benzylidene-5-oxo-2-phenyl-imidazol-1-yl] acetate
  参考文献：
  名称：

  Novel, selective mechanism-based inhibitors of the herpes proteases

  摘要：

  A novel class of inhibitor of the herpes proteases acting upon the catalytic apparatus by forming covalent complexes are described. Two new families of inhibitor, the spirocyclopropyI oxazolones and the benzylidine N-sulphonyloxyimidazolones, have been shown to be submicromolar inhibitors of HSV-2 and HCMV proteases which are selective relative to a panel of standard serine proteases. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00456-8

文献信息

• Novel, selective mechanism-based inhibitors of the herpes proteases
  作者：Ivan L. Pinto、Andrew West、Christine M. Debouck、Anthony G. DiLella、Joselina G. Gorniak、Kevin C. O'Donnell、Daniel J. O'Shannessy、Arunbai Patel、Richard L. Jarvest

  DOI：10.1016/0960-894x(96)00456-8

  日期：1996.10

  A novel class of inhibitor of the herpes proteases acting upon the catalytic apparatus by forming covalent complexes are described. Two new families of inhibitor, the spirocyclopropyI oxazolones and the benzylidine N-sulphonyloxyimidazolones, have been shown to be submicromolar inhibitors of HSV-2 and HCMV proteases which are selective relative to a panel of standard serine proteases. Copyright (C) 1996 Elsevier Science Ltd