N-[(E)-[4-[2-[1-(6-chloropyridazin-3-yl)piperidin-4-yl]ethoxy]phenyl]methylideneamino]methanamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N-[(E)-[4-[2-[1-(6-chloropyridazin-3-yl)piperidin-4-yl]ethoxy]phenyl]methylideneamino]methanamine
• 化学式: C₁₉H₂₄ClN₅O
• 分子量: 373.885
• InChiKey: DPBKFPPQSXISMH-HYARGMPZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  62.6
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3-chloro-6-[4-(2-chloroethyl)-1-piperidynyl]pyridazine 在 potassium carbonate 作用下， 以 乙醇 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 48.0h， 生成 N-[(E)-[4-[2-[1-(6-chloropyridazin-3-yl)piperidin-4-yl]ethoxy]phenyl]methylideneamino]methanamine
  参考文献：
  名称：

  An Orally Bioavailable Oxime Ether Capsid Binder with Potent Activity against Human Rhinovirus

  摘要：

  A series of capsid-binding compounds was screened against human rhinovirus (HRV) using a CPE based assay. The ethyl oxime ether 14 was found to have outstanding anti-HRV activity (median IC50 4.75 ng/mL), and unlike the equivalent ethyl ester compound 3 (Pirodavir), it has good oral bioavailability, making it a promising development candidate. Compound 14 illustrates that an oxime ether group can act as a metabolically stable bioisostere for an ester functionality.

  DOI：

  10.1021/jm0202876

文献信息

• An Orally Bioavailable Oxime Ether Capsid Binder with Potent Activity against Human Rhinovirus
  作者：Keith G. Watson、Renee N. Brown、Rachel Cameron、David K. Chalmers、Stephanie Hamilton、Betty Jin、Guy Y. Krippner、Angela Luttick、Darryl B. McConnell、Phillip A. Reece、Jane Ryan、Pauline C. Stanislawski、Simon P. Tucker、Wen-Yang Wu、Dale L. Barnard、Robert W. Sidwell

  DOI：10.1021/jm0202876

  日期：2003.7.1

  A series of capsid-binding compounds was screened against human rhinovirus (HRV) using a CPE based assay. The ethyl oxime ether 14 was found to have outstanding anti-HRV activity (median IC50 4.75 ng/mL), and unlike the equivalent ethyl ester compound 3 (Pirodavir), it has good oral bioavailability, making it a promising development candidate. Compound 14 illustrates that an oxime ether group can act as a metabolically stable bioisostere for an ester functionality.