7-Iodo-6-methyl-1,4-dihydro-pyrido[2,3-b]pyrazine-2,3-dione | 185676-60-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶吡嗪类
• 英文名称: 7-Iodo-6-methyl-1,4-dihydro-pyrido[2,3-b]pyrazine-2,3-dione
• 英文别名: 7-Iodo-6-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
• CAS: 185676-60-2
• 化学式: C₈H₆IN₃O₂
• 分子量: 303.059
• InChiKey: ZSDXFPYVSKYWPP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  71.1
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  7-Iodo-6-methyl-1,4-dihydro-pyrido[2,3-b]pyrazine-2,3-dione 在 双氧水 作用下， 生成 7-Iodo-6-methyl-5-oxy-1,4-dihydro-pyrido[2,3-b]pyrazine-2,3-dione
  参考文献：
  名称：

  Synthesis and biological evaluation of pyrido[2,3-b]pyrazine and pyrido[2,3-b]pyrazine-n-oxide as selective glycine antagonists

  摘要：

  Pyrido[2,3-b]pyrazines and pyrido[2,3-b]pyrazines-N-oxides have been synthesized and evaluated for in vitro/in vivo antagonistic activity at the glycine site on the NMDA receptor. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/s0960-894x(96)00492-1
• 作为产物：
  描述：

  5-Iodo-6-methyl-3-nitro-pyridin-2-ylamine 在 铁粉 、 calcium chloride 作用下， 生成 7-Iodo-6-methyl-1,4-dihydro-pyrido[2,3-b]pyrazine-2,3-dione
  参考文献：
  名称：

  Synthesis and biological evaluation of pyrido[2,3-b]pyrazine and pyrido[2,3-b]pyrazine-n-oxide as selective glycine antagonists

  摘要：

  Pyrido[2,3-b]pyrazines and pyrido[2,3-b]pyrazines-N-oxides have been synthesized and evaluated for in vitro/in vivo antagonistic activity at the glycine site on the NMDA receptor. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/s0960-894x(96)00492-1

文献信息

• Synthesis and biological evaluation of pyrido[2,3-b]pyrazine and pyrido[2,3-b]pyrazine-n-oxide as selective glycine antagonists
  作者：Alfredo Cugola、Daniele Donati、M. Guarneri、Fabrizio Micheli、Andrea Missio、Angelo Pecunioso、Angelo Reggiani、G. Tarzia、V. Zanirato

  DOI：10.1016/s0960-894x(96)00492-1

  日期：1996.11

  Pyrido[2,3-b]pyrazines and pyrido[2,3-b]pyrazines-N-oxides have been synthesized and evaluated for in vitro/in vivo antagonistic activity at the glycine site on the NMDA receptor. Copyright (C) 1996 Elsevier Science Ltd

表征谱图