indole-2-thione | 210288-06-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: indole-2-thione
• CAS: 210288-06-5
• 化学式: C₈H₅NS
• 分子量: 147.2
• InChiKey: BWHXBNDMKJOQIE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  44.4
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-benzoylaminomethylthio-1H-indole 生成 indole-2-thione
  参考文献：
  名称：

  An expeditious synthesis for γ-carboline analogue 4-aryl-1,3-thiazino[6,5-b]indole derivatives via the trifluoromethanesulfonic acid-promoted isomerization of 3-amidomethylthioindole intermediates to 2-indolyl sulfides

  摘要：

  A highly efficient trifluoromethanesulfonic acid-mediated rearrangement of the benzoylaminomethylthio group of 3-benzoylaminomethylthioindoles (7a-e) to position 2 of the indole ring was developed. Thus, 2-benzoylaminomethylthioindoles (9a-e) were obtained in good yields and were involved as key intermediates in the synthesis of the new gamma-carboline analogue ring system: 2,9-dihydro-4-aryl-1,3-thiazino[6,5-b]indole derivatives (11a-e). The target thiazinoindoles (11a-e) were prepared via 2-thiobenzoylaminomethylindoles (10a-e) in modified Bischler-Napieralski reactions. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.11.099

文献信息

• Purification of progesterone receptor modulators
  申请人：Wilk Kazimierz Bogdan

  公开号：US20050250766A1

  公开（公告）日：2005-11-10

  Methods for purifying a compound of formula I are provided, wherein A, B X, Q, and R 1 are defined herein. The methods include mixing the compound of formula I and a solvent; adding a base to the solvent; and precipitating purified compound of formula I.

  提供了一种纯化式I化合物的方法，其中A、B、X、Q和R1在此处被定义。该方法包括将式I化合物与溶剂混合；向溶剂中加入碱；并沉淀纯化的式I化合物。
• Substituted indole compounds and methods of their use
  申请人：——

  公开号：US20020115700A1

  公开（公告）日：2002-08-22

  5-(3-Isatinylidinyl)thiazolidineones and 3-(thiazolidinon-5-yl)indoles compounds, compositions, and methods of inhibiting telomerase activity in vitro and treatment of telomerase mediated conditions or diseases ex vivo and in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of conditions or diseases mediated by telomerase activity, such as in the treatment of cancer. Also disclosed are novel methods for assaying or screening for inhibitors of telomerase activity.

  本发明提供了5-(3-异色烟酰亚胺基)噻唑啉酮和3-(噻唑啉-5-基)吲哚类化合物、组合物和方法，用于体外抑制端粒酶活性和体内外治疗端粒酶介导的疾病或病症。本发明的方法、化合物和组合物可单独使用，或与其他药理活性剂联合使用，用于治疗由端粒酶活性介导的疾病或病症，例如治疗癌症。本发明还揭示了新的检测或筛选端粒酶活性抑制剂的方法。
• AZIDO PURINE NUCLEOSIDES FOR TREATMENT OF VIRAL INFECTIONS
  申请人：Schinazi Raymond F.

  公开号：US20100279969A1

  公开（公告）日：2010-11-04

  The present invention is directed to compounds, compositions and methods for treating or preventing viral infections, in particular, HIV, HBV, and HCV, in human patients or other animal hosts. The compounds are 3′-azido-2′,3′-dideoxy purine nucleosides or phosphonates, and pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof. In particular, the compounds show potent antiviral activity against HIV-1 resistance mutants including HIV-1 K65R , HTV-1 K70E , HIV-1 L74V , HIV-1 M184V , HIV-1 Q151M and inhibitory activity against HIV-1 RT harboring TAMS or insertion mutations including HIV-1 AZT3 , HIV-1 AZT7 , HIV-1 AZT9 , HIV-1 Q151M , or HIV-1 69insertion . In one embodiment, the compounds are 3′-azido-ddA, 3′-azido-ddG, or combinations thereof, administered with one or more additional antiviral agents that select for TAM mutations and/or the M 184V mutation, along with a pharmaceutically acceptable carrier.

  本发明涉及化合物、组合物和方法，用于治疗或预防病毒感染，特别是HIV、HBV和HCV，在人类患者或其他动物宿主中。这些化合物是3'-氮杂-2'，3'-二脱氧嘌呤核苷或膦酸盐，以及其它药物可接受的盐、前药和衍生物。特别地，这些化合物对HIV-1耐药突变体，包括HIV-1K65R、HTV-1K70E、HIV-1L74V、HIV-1M184V、HIV-1Q151M显示出强效的抗病毒活性，并且具有抑制HIV-1 RT携带TAMS或插入突变的活性，包括HIV-1AZT3、HIV-1AZT7、HIV-1AZT9、HIV-1Q151M或HIV-169插入。在一种实施方式中，这些化合物是3'-氮杂-ddA、3'-氮杂-ddG或其组合物，与一个或多个选择TAM突变和/或M 184V突变的其它抗病毒药物一起，以及药物可接受的载体一起给予。
• PURIFICATION OF PROGESTERONE RECEPTOR MODULATORS
  申请人：Wilk Bogdan Kazimierz

  公开号：US20130012702A1

  公开（公告）日：2013-01-10

  Methods for purifying a compound of formula I are provided, wherein A, B, X, Q, and R 1 are defined herein. The methods include mixing the compound of formula I and a solvent; adding a base to the solvent; and precipitating purified compound of formula I.

  本文提供了一种公式I化合物的纯化方法，其中A、B、X、Q和R1在此定义。该方法包括将公式I化合物与溶剂混合；向溶剂中加入碱；并沉淀纯化的公式I化合物。
• Indoles as insecticides and acaricides
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0697172A1

  公开（公告）日：1996-02-21

  There are provided methods for the control of insects and the protection of crops from the damage caused thereby which comprise the use of an indole compound of formula I

  提供了防治昆虫和保护农作物免受昆虫危害的方法，其中包括使用式 I 的吲哚化合物