2,3,4,4A,4B,8A,9,9A-Octahydro-1H-carbazole | 67262-18-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2,3,4,4A,4B,8A,9,9A-Octahydro-1H-carbazole
• CAS: 67262-18-4
• 化学式: C₁₂H₁₇N
• 分子量: 175.27
• InChiKey: SHQAGYRIWMHMRU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] NOVEL ORGANIC ELECTROLUMINESCENCE COMPOUNDS AND ORGANIC ELECTROLUMINESCENCE DEVICE USING THE SAME<br/>[FR] NOUVEAUX COMPOSÉS ÉLECTROLUMINESCENTS ORGANIQUES ET DISPOSITIF ÉLECTROLUMINESCENT ORGANIQUE LES UTILISANT
  申请人：ROHM & HAAS ELECT MAT

  公开号：WO2013012297A1

  公开（公告）日：2013-01-24

  The present invention relates to a novel organic luminescent compound and an organic electroluminescence device containing the same. The compounds according to the present invention have high luminous efficiency and long operation lifetime. Therefore, they can produce an organic electroluminescent device which improves power consumption.

  本发明涉及一种新型有机发光化合物以及含有该化合物的有机电致发光器件。根据本发明的化合物具有高发光效率和长寿命。因此，它们可以生产出改善功耗的有机电致发光器件。
• Benzylpiperazinyl-indolinylethanones
  申请人：Neurogen Corporation.

  公开号：US20020128274A1

  公开（公告）日：2002-09-12

  Disclosed are benzylpiperazinyl-indolinylethanone compounds which are useful for the treatment and/or prevention of neuropsychological disorders including, but not limited to, schizophrenia, mania, dementia, depression, anxiety, compulsive behavior, substance abuse, Parkinson-like motor disorders and motion disorders related to the use of neuroleptic agents. Pharmaceutical compositions, including packaged pharmaceutical compositions, are further provided. Compounds of the invention are also useful as probes for the localization of GABA A receptors in tissue samples.

  揭示了苯甲基哌嗪基吲哚基乙酮类化合物，其可用于治疗和/或预防神经心理障碍，包括但不限于精神分裂症、狂躁症、痴呆、抑郁症、焦虑症、强迫行为、物质滥用、帕金森病样运动障碍和与神经阻滞剂使用相关的运动障碍。此外，还提供了制药组合物，包括包装的制药组合物。该发明的化合物还可用作组织样本中GABAA受体的定位探针。
• Tetrahydroindole Derivatives for Treatment of Alzheimer's Disease
  申请人：Burkamp Frank

  公开号：US20100016308A1

  公开（公告）日：2010-01-21

  Tetrahydroindole derivatives of formula (I): are disclosed. These compounds modulate the activity of gamma-secretase and hence find use in treatment or prevention of Alzheimer's disease.

  公开了式(I)的四氢吲哚衍生物。这些化合物调节γ-分泌酶的活性，因此可用于治疗或预防阿尔茨海默病。
• Hydrogen storage by reversible hydrogenation of pi-conjugated substrates
  申请人：Pez Peter Guido

  公开号：US20050002857A1

  公开（公告）日：2005-01-06

  Processes are provided for the storage and release of hydrogen by means of a substantially reversible catalytic hydrogenation of extended pi-conjugated substrates which include large polycyclic aromatic hydrocarbons, polycyclic aromatic hydrocarbons with nitrogen heteroatoms, polycyclic aromatic hydrocarbons with oxygen heteroatoms, polycyclic aromatic hydrocarbons with alkyl, alkoxy, nitrile, ketone, ether or polyether substituents, pi-conjugated molecules comprising 5 membered rings, pi-conjugated molecules comprising six and five membered rings with nitrogen or oxygen hetero atoms, and extended pi-conjugated organic polymers. The hydrogen, contained in the at least partially hydrogenated form of the extended pi-conjugated system, can be facilely released for use by a catalytic dehydrogenation of the latter in the presence of a dehydrogenation catalyst which can be effected by lowering the hydrogen gas pressure, generally to pressures greater than 0.1 bar or raising the temperature to less than 250° C. or less, or by a combination of these two process parameters.

  本发明提供了通过对扩展的π-共轭基质进行基本可逆的催化加氢来储存和释放氢气的工艺、具有烷基、烷氧基、腈基、酮基、醚基或聚醚基取代基的多环芳香烃，由 5 个成员环组成的π-共轭分子，由具有氮或氧杂质原子的 6 个和 5 个成员环组成的π-共轭分子，以及扩展的π-共轭有机聚合物。扩展π-共轭体系的至少部分氢化形式中含有的氢，可以在脱氢催化剂的存在下，通过催化脱氢反应方便地释放出来，脱氢反应可以通过降低氢气压力（一般压力大于 0.1 巴）或将温度升高到低于 250 摄氏度或更低，或通过这两种工艺参数的组合来实现。
• TETRAHYDROINDOLE DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE
  申请人：MERCK SHARP & DOHME LTD.

  公开号：EP1948603B1

  公开（公告）日：2011-08-10