Tocris-1038

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: Tocris-1038
• 英文别名: [(11R)-2-methyl-11-(morpholin-4-ylmethyl)-9-oxa-1-azatricyclo[6.3.1.04,12]dodeca-2,4(12),5,7-tetraen-3-yl]-naphthalen-2-ylmethanone
• 化学式: C₂₇H₂₆N₂O₃
• 分子量: 426.5
• InChiKey: YIZIGGXNFRIVFS-JOCHJYFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  43.7
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Receptor Selective Cannabimimetic Aminoalkylindoles
  申请人：Makriyannis Alexandros

  公开号：US20070243134A1

  公开（公告）日：2007-10-18

  Disclosed are cannabimimetic aminoalkylindole compounds and methods for their manufacture. The disclosed compounds are surprisingly potent and selective cannabinoids. The disclosed compounds may include radioactive atoms. Also disclosed are methods of using the disclosed compounds, including use of the disclosed compounds to stimulate a cannabinoid receptor, to provide a physiological effect in an animal or individual, to treat a condition in an animal or individual and for use in radioimaging.

  本发明涉及大麻类氨基烷基吲哚化合物及其制备方法。所述化合物具有惊人的强效和选择性大麻素。所述化合物可能包括放射性原子。本发明还涉及使用所述化合物的方法，包括使用所述化合物刺激大麻素受体，在动物或个体中产生生理效应，治疗动物或个体的疾病以及用于放射性成像。
• Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
  申请人：Kõster Hubert

  公开号：US20100248264A1

  公开（公告）日：2010-09-30

  Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures. Automated systems for performing the methods also are provided.

  提供了捕获化合物及其集合以及使用这些化合物进行生物分子分析的方法。特别地，提供了用于分析复杂蛋白质混合物（如蛋白质组）的集合、化合物和方法。这些化合物是多功能试剂，可用于分离和分离复杂的蛋白质混合物。还提供了执行这些方法的自动化系统。
• Cannabimimetic indole derivatives
  申请人：The University of Connecticut

  公开号：EP1702617A1

  公开（公告）日：2006-09-20

  Novel cannabimimetic indole derivatives are presented which have preferentially high affinities for one of the cannabinoid CB1 or CB2 receptor sites. The improved receptor affinity makes these analogs therapeutically useful as medications in individual and animals for treatment of pain, glaucoma, epilepsy, nausea associated with chemotherapy.

  本研究介绍了新型大麻拟物吲哚衍生物，它们对大麻素 CB1 或 CB2 受体位点之一具有较高的亲和力。受体亲和力的提高使这些类似物在治疗疼痛、青光眼、癫痫、化疗引起的恶心等疾病时，可作为个体和动物的治疗药物。
• Methods and compositions for treating cancer
  申请人：Sutter West Bay Hospitals

  公开号：US11344527B2

  公开（公告）日：2022-05-31

  This disclosure provides compositions and method useful for treating cell proliferative disorders including cancer. The disclosure provides cannabidiol derivatives and compositions thereof either alone or in combination with THC or a derivative thereof.

  本公开提供了用于治疗包括癌症在内的细胞增殖性疾病的组合物和方法。本公开提供了大麻二酚衍生物及其单独或与四氢大麻酚或其衍生物结合使用的组合物。
• CANNABIMIMETIC INDOLE DERIVATIVES
  申请人：The University of Connecticut

  公开号：EP1223929B1

  公开（公告）日：2006-08-23