[4,4'-联苯二基二(氧基)]二(三甲基硅烷) | 1094-86-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: [4,4'-联苯二基二(氧基)]二(三甲基硅烷)
• 英文名称: bistrimethyl(4,4'-biphenoxy)silane
• 英文别名: 4,4'-bis(trimethylsiloxy)biphenyl；4.4'-Bis--biphenyl；4,4'-Dihydroxydiphenyl-di-trimethylsilyl；4,4'-Bis-trimethylsilyloxy-biphenyl；4,4-Di-(trimethylsilyloxy)-diphenyl；Di-(2,2'-trimethylsiloxy)-diphenyl；Silane, [[1,1'-biphenyl]-4,4'-diylbis(oxy)]bis[trimethyl-；trimethyl-[4-(4-trimethylsilyloxyphenyl)phenoxy]silane
• CAS: 1094-86-6
• 化学式: C₁₈H₂₆O₂Si₂
• 分子量: 330.574
• InChiKey: IRXVVRLNZOQOJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.78
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2931900090

反应信息

• 作为反应物：
  描述：

  [4,4'-联苯二基二(氧基)]二(三甲基硅烷) 在 甲醇 、 1,3-disulfonic acid imidazolium hydrogen sulfate 作用下， 反应 0.08h， 以97%的产率得到4,4'-二羟基联苯
  参考文献：
  名称：

  Preparation, characterization and use of 1,3-disulfonic acid imidazolium hydrogen sulfate as an efficient, halogen-free and reusable ionic liquid catalyst for the trimethylsilyl protection of hydroxyl groups and deprotection of the obtained trimethylsilanes

  摘要：

  Novel 1,3-disulfonic acid imidazolium hydrogen sulfate, a halogen-free ionic liquid, is a recyclable and eco-benign catalyst for the trimethylsilyl protection of hydroxyl groups at room temperature under solvent free conditions to afford trimethylsilanes in excellent yields (92-100%) and in very short reaction times (1-5 min). Deprotection of the resulting trimethylsilanes can also be achieved using the same catalyst in methanol. The catalyst was characterized by IR. H-1 NMR, C-13 NMR and MS studies. All the products were extensively characterized by IR, H-1 NMR, MS, and elemental and melting point analyses. This new method consistently has the advantages of excellent yields and short reaction times. Further, the catalyst can be recovered and reused for several times without loss of activity. The work-up of the reaction consists of a simple separation, followed by concentration of the crude product and purification. (C) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcata.2012.08.002
• 作为产物：
  描述：

  4,4'-二羟基联苯 、 乙烯基三甲基硅烷 在 Wilkinson's catalyst 作用下， 以 甲苯 为溶剂， 反应 2.0h， 以93%的产率得到[4,4'-联苯二基二(氧基)]二(三甲基硅烷)
  参考文献：
  名称：

  半胱天冬酶抑制剂对大鼠椎间盘细胞的抗凋亡作用。

  摘要：

  背景技术细胞凋亡被认为是椎间盘退变的关键因素。Fas介导的细胞凋亡的两个主要途径已被确定：I型是诱导死亡的信号复合物途径，II型是线粒体途径。纤维纤维细胞的凋亡途径在表型上与髓核细胞不同，在我们的知识中尚未阐明。凋亡的最终引发者或执行者是胱天蛋白酶。也有胱天蛋白酶的抑制剂，其有可能被用作抗凋亡治疗剂。因此，我们进行了这项研究，以确定（1）纤维环细胞的凋亡途径和（2）caspase抑制剂的抗凋亡潜力。方法分离，培养大鼠纤维环，并置于0％（促凋亡条件）或10％（正常对照）胎牛血清中。我们确定并量化了凋亡细胞死亡，caspase活性和线粒体膜电位丧失的存在。此外，我们检查了细胞中Fas，procaspases和细胞色素c的表达。最后，我们分析了caspase抑制剂对1％胎牛血清中细胞的抗凋亡作用的程度。结果与在10％胎牛血清中孵育的细胞相比，在0％胎牛血清中孵育的细胞凋亡和Fas表达的百分比增加（均p

  DOI：

  10.2106/jbjs.e.00762

文献信息

• A Highly Efficient Method for the Silylation of Alcohols, Phenols, and Naphthols Using HMDS in the Presence of Zinc Oxide (ZnO) as Economical Heterogeneous Catalyst
  作者：Hamid Reza Shaterian、Majid Ghashang

  DOI：10.1080/10426500701569406

  日期：2007.12.24

  Variety alcohols, phenols, and naphthols were effectively converted into their corresponding trimethylsilyl ether with hexamethyldisilazane in the presence of zinc oxide under very mild and ambient conditions with short reaction time in good to excellent yields.

  在氧化锌的存在下，在非常温和的环境条件下，各种醇类、酚类和萘酚类与六甲基二硅氮烷一起有效转化为相应的三甲基甲硅烷基醚，反应时间短，收率良好。
• Alumina Sulfuric Acid as an Efficient and Recyclable Heterogeneous Catalyst for the O-Silylation of Alcohols, Phenols, and Oximes
  作者：Hamid Reza Shaterian、Fahimeh Khorami、Azita Amirzadeh、Majid Ghashang、Asghar Hosseinian

  DOI：10.1080/10426500801967955

  日期：2008.9.15

  Alumina sulfuric acid as a recyclable catalyst conducts the transformation of various types of alcohol, phenols, and oximes with hexamethyldisilazane (HMDS) to the corresponding O-trimethylsilylated compounds in good to excellent yields under mild and ambient conditions with short reaction times. The method is highly selective for the conversion of primary alcohols in the presence of secondary and

  硫酸氧化铝作为可回收催化剂，在温和和环境条件下，反应时间短，可将各种类型的醇、酚和肟与六甲基二硅氮烷 (HMDS) 转化为相应的 O-三甲基硅烷化化合物，收率良好至极好。该方法在仲醇和叔醇存在下对伯醇的转化具有高度选择性。此外，催化剂可以很容易地回收和重复使用至少八次，而不会检测到反应性的损失。
• An efficient method for the silylation of hydroxyl groups with hexamethyldisilazane (HMDS) catalyzed by aluminum tris(dihydrogen phosphate) under solvent-free and ambient conditions
  作者：Hamid Reza Shaterian、Majid Ghashang、Nassrin Tajbakhsh Riki、Manijeh Asadi

  DOI：10.1139/v08-086

  日期：2008.8.1

  A highly efficient and mild procedure for the trimethylsilylation of a wide variety of alcohols, including primary, benzylic, secondary, hindered secondary, tertiary, phenols, and oximes with hexamethyldisilazane (HMDS), using Al(H2PO4)3 as a recyclable heterogeneous catalyst at room temperature in a few minutes with excellent yields under solvent-free conditions is described.Key words: trimethylsilylation

  使用 Al(H2PO4)3 作为可回收的多相催化剂，使用 Al(H2PO4)3 作为可回收的多相催化剂，使用六甲基二硅氮烷 (HMDS) 对包括伯醇、苄醇、仲醇、受阻仲醇、叔醇、酚类和肟在内的各种醇类进行三甲基硅烷化的高效和温和程序描述了在无溶剂条件下在室温下几分钟以优异的收率。关键词：三甲基甲硅烷基化，六甲基二硅氮烷，三（磷酸二氢）铝 [Al(H2PO4)3]，无溶剂，羟基。
• Alumina Perchloric Acid (Al_{<b><i>2</i></b>}O_{<b><i>3</i></b>}-HClO_{<b><i>4</i></b>}) as an Efficient Heterogeneous Catalyst for Modified Preparation of Trimethylsilyl Ethers
  作者：Hamid Reza Shaterian、Fahimeh Khorami、Azita Amirzadeh、Majid Ghashang

  DOI：10.1080/10426500802021539

  日期：2008.10.7

  for the trimethylsilylation of a wide variety of alcohols, including primary, benzylic, secondary, hindered secondary, tertiary, phenols, and oximes with hexamethyldisilazane (HMDS) using alumina perchloric acid (Al 2 O 3 -HClO 4 ) as recyclable heterogeneous catalyst in excellent yields with short reaction times (3−65 min) under ambient conditions is described.

  使用高氯酸氧化铝 (Al 2 O 3 -HClO 4 ) 使用六甲基二硅氮烷 (HMDS) 对多种醇类（包括伯醇、苄醇、仲醇、受阻仲醇、叔醇、酚类和肟）进行三甲基硅烷化的高效和温和程序描述了在环境条件下具有短反应时间（3-65 分钟）的可回收多相催化剂。
• Multicyclic Poly(ether ketone)s Obtained by Polycondensation of 2,6,4‘-Trifluorobenzophenone with Various Diphenols
  作者：Hans R. Kricheldorf、Radka Hobzova、Lali Vakhtangishvili、Gert Schwarz

  DOI：10.1021/ma050037+

  日期：2005.5.1

  2,6,4‘-Trifluorobenzophenone (TFB) was polycondensed with silylated 4,4‘-dihydroxybiphenyl (DHBP) or silylated bisphenol A in N-methylpyrrolidone by means of K2CO3 as catalyst and HF acceptor. At constant concentration (0.08 mol/L) the feed ratio was varied from 1.0/1.0 to 1.0/1.5. For polycondensations of DHBP cross-linking was observed for feed ratios above 1.0/1.1, whereas no gelation occurred with

  通过K 2 CO 3将2,6,4'-三氟二苯甲酮（TFB）与甲硅烷基化的4,4'-二羟基联苯（DHBP）或甲硅烷基化的双酚A在N-甲基吡咯烷酮中进行缩聚。作为催化剂和HF受体。在恒定浓度（0.08 mol / L）下，进料比从1.0 / 1.0变化至1.0 / 1.5。对于DHBP的缩聚，在进料比高于1.0 / 1.1时观察到交联，而与双酚A无关，无论进料比如何都没有发生凝胶化。MALDI-TOF质谱法在所有情况下均证明了环状，双环和多环低聚物和聚合物的形成。在进料比为1.00 / 1.48的情况下，没有官能团（末端）的多环化合物是唯一的反应产物。然而，只有当TFB的初始浓度降低到0.04 mol / L时才避免凝胶化。在这些优化的条件下，又将三双类似双酚A的二酚与TBP缩聚，并再次获得了不含官能团的多环作为主要反应产物。6 -10 9达。