distearyl succinate | 26720-12-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: distearyl succinate
• 英文别名: Bernsteinsaeure-dioctadecylester；Dioctadecyl-succinat；dioctadecyl butanedioate
• CAS: 26720-12-7
• 化学式: C₄₀H₇₈O₄
• 分子量: 623.057
• InChiKey: KYZQKJZPHLFERP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  17.5
• 重原子数：
  44
• 可旋转键数：
  39
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  硬脂醇 、 丁二酸 在 硫酸 作用下， 以 苯 为溶剂， 生成 distearyl succinate
  参考文献：
  名称：

  Schlenk,W., Justus Liebigs Annalen der Chemie, 1969, vol. 727, p. 1 - 9

  摘要：

  DOI：

文献信息

• Remote detection of substance delivery to cells
  申请人：Drummond C. Daryl

  公开号：US20050112065A1

  公开（公告）日：2005-05-26

  The present invention provides for the development of endocytosis-sensitive probes, and a remote method for measuring cellular endocytosis. These probes are based on the reduced water permeability of a nanoparticle or liposomal delivery system, and inherent degradability or disruption of barrier integrity upon endocytosis. The invention also provides for liposomes having combined therapeutic and diagnostic utilities by co-encapsulating ionically coupled diagnostic and therapeutic agents, in one embodiment, by a method using anionic chelators to prepare electrochemical gradients for loading of amphipathic therapeutic bases into liposomes already encapsulating an imaging agent. The invention provides for imaging of therapeutic liposomes by inserting a lipopolymer anchored, remotely sensing reporter molecules into liposomal lipid layer. The invention allows for an integrated delivery system capable of imaging molecular fingerprints in diseased tissues, treatment, and treatment monitoring.

  本发明提供了一种用于开发内吞敏感探针的方法，以及一种测量细胞内吞的远程方法。这些探针基于纳米颗粒或脂质体递送系统的降低水透性，以及内吞时固有的可降解性或屏障完整性破坏。该发明还提供了一种具有联合治疗和诊断功能的脂质体，通过共包埋离子耦合的诊断和治疗剂，其中一种实施方式是使用阴离子螯合剂的方法，为脂质体内已包埋成像剂的脂质体加载两性治疗碱。该发明通过将脂质体脂质层插入脂质聚合物锚定的远程感测报告分子来成像治疗脂质体。该发明允许集成递送系统成像疾病组织中的分子指纹，治疗和治疗监测。
• THERMAL ENERGY STORAGE AND TEMPERATURE STABILIZATION PHASE CHANGE MATERIALS COMPRISING ALKANOLAMIDES AND DIESTERS AND METHODS FOR MAKING AND USING THEM
  申请人：Entropy Solutions Inc.

  公开号：US20170044414A1

  公开（公告）日：2017-02-16

  This invention generally relates to thermoregulation and temperature stabilization, thermal protection and insulation, and nucleating agents. In particular, in alternative embodiments, provided are organic phase change materials comprising diesters and alkanolamides. In alternative embodiments, provided are Phase Change Material (PCMs) compositions comprising diesters and alkanolamides, and methods for making and using them. In alternative embodiments, the Phase Change Material (PCMs) compositions are used for thermal energy management, including energy storage and/or temperature stabilization, in various applications such as building, automotive, packaging, garment and footwear, textiles, fabrics, synthetic fibers, foods, microcapsules and other energy storage systems.

  这项发明通常涉及热调节和温度稳定、热保护和隔热以及成核剂。特别是，在替代实施方案中，提供了包括二酯和脂肪醇胺的有机相变材料。在替代实施方案中，提供了包括二酯和脂肪醇胺的相变材料（PCM）组合物，并提供了制备和使用它们的方法。在替代实施方案中，相变材料（PCM）组合物用于热能管理，包括在建筑、汽车、包装、服装和鞋类、纺织品、织物、合成纤维、食品、微胶囊和其他能量存储系统等各种应用中的能量存储和/或温度稳定。
• Medical Adhesive
  申请人：Yoshimura Tetsuji

  公开号：US20070282093A1

  公开（公告）日：2007-12-06

  The present invention has its object to provide a medical adhesive excellent in safety, reactivity (curing rate) and duration of adhesive strength. A medical adhesive of the present invention comprises a hydrophilic urethane prepolymer (UP) obtained by reacting a fluorine-containing nonaromatic polyisocyanate component (A) and a polyol component (B) having a hydrophilic polyol (B 1 ) as the essential component, and a phenolic radical scavenger (PRS). The content of (PRS) is preferably 0.01 to 3% by weight based on the weight of (UP). The content of oxyethylene groups in (B) is preferably 30 to 100% by weight based on the weight of the oxyalkylene groups in (B). Preferably, (B) is a mixture of a random copolymer obtained by addition of ethylene oxide and propylene oxide to diols and polypropylene glycol. The content of isocyanate groups in the medical adhesive is 1 to 10% by weight based on the weight of (UP). The medical adhesive of the present invention is suitable for bonding body tissues, such as lung, artery and heart in particular.

  本发明的目的是提供一种在安全性、反应性（固化速率）和粘接强度持续时间方面具有优异性能的医用粘合剂。本发明的医用粘合剂包括通过反应含氟非芳香族多异氰酸酯组分（A）和具有亲水性多元醇（B1）作为基本组分的多元醇组分（B）获得的亲水性聚氨酯预聚物（UP）和酚类自由基清除剂（PRS）。根据（UP）的重量，（PRS）的含量优选为0.01至3重量％。根据（B）中氧乙烯基团的重量，氧乙烯基团的含量优选为30至100重量％。优选地，（B）是通过将环氧丙烷和丙烯酸酯添加到双醇和聚丙烯醇中获得的随机共聚物的混合物。医用粘合剂中异氰酸酯基团的含量根据（UP）的重量为1至10重量％。本发明的医用粘合剂特别适用于粘接肺、动脉和心脏等体内组织。
• PEG LIPIDS AND USES THEREOF
  申请人：Moderna TX, Inc.

  公开号：US20220047518A1

  公开（公告）日：2022-02-17

  The present disclosure in part provides compounds (i.e., PEG lipids) which are useful in pharmaceutical compositions, cosmetic compositions, and drug delivery systems, e.g, for use in lipid nanoparticle (LNP) formulations. The present disclosure also provides LNP formulations comprising PEG lipids described herein, and methods of using the same. For example, the LNPs provided herein are useful for the delivery of an agent (e.g, therapeutic agent) to a subject. The PEG lipids and LNPs provided herein, in certain embodiments, exhibit increased PEG shedding compared to existing PEG lipids and LNP formulations.

  本公开部分提供了化合物（即PEG脂质），这些化合物在制药组合物、化妆品组合物和药物递送系统中非常有用，例如用于脂质纳米粒（LNP）配方。本公开还提供了包含此处所述PEG脂质的LNP配方以及使用它们的方法。例如，此处提供的LNP对于将药物（例如治疗药物）递送到主体中非常有用。在某些实施例中，此处提供的PEG脂质和LNP表现出比现有的PEG脂质和LNP配方更高的PEG脱落。
• Imparting anti-soiling properties to fibres
  申请人：BADISCHE CORPORATION

  公开号：EP0051357A1

  公开（公告）日：1982-05-12

  Anti-soiling properties are imparted to fibres by applying thereto an effective amount of the neutralized phosphate ester of an aliphatic alcohol having from 12 to 22 carbon atoms in the chain.

  通过在纤维上涂抹有效量的链上有 12 至 22 个碳原子的脂肪醇的中和磷酸酯，可赋予纤维防污特性。