(S)-N-((S)-1-amino-4-methyl-1-oxopentan-2-yl)-5-oxopyrrolidine-2-carboxamide | 61798-77-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-N-((S)-1-amino-4-methyl-1-oxopentan-2-yl)-5-oxopyrrolidine-2-carboxamide
• 英文别名: (2S)-N-[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]-5-oxopyrrolidine-2-carboxamide
• CAS: 61798-77-4
• 化学式: C₁₁H₁₉N₃O₃
• 分子量: 241.29
• InChiKey: BBCYDAHZVXRRDJ-YUMQZZPRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  101
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  Fmoc-O-叔丁基-L-谷氨酸 、 alkaline earth salt of/the/ methylsulfuric acid 以88.7%的产率得到(S)-N-((S)-1-amino-4-methyl-1-oxopentan-2-yl)-5-oxopyrrolidine-2-carboxamide
  参考文献：
  名称：

  Solid phase synthesis of 1-substituted pyroglutamates

  摘要：

  Starting from a dipeptide containing the Bu-t ester of glutamic acid, disubstituted 2-pyrrolidinones were prepared in good yield and high purity. Cyclization takes place using DPPA as activating reagent. Diversity was achieved through reductive alkylation of the starting dipeptide and N-alkylation following the cyclization step. This approach has been used for the synthesis of both individual compounds and mixture-based combinatorial libraries. (C) 2000 Elsevier Science Ltd, All rights reserved.

  DOI：

  10.1016/s0040-4039(99)02208-x

文献信息

• [EN] SMALL MOLECULES AGAINST CEREBLON TO ENHANCE EFFECTOR T CELL FUNCTION<br/>[FR] PETITES MOLÉCULES DIRIGÉES CONTRE LE CÉRÉBLON POUR AMÉLIORER LA FONCTION DES LYMPHOCYTES T EFFECTEURS
  申请人：H LEE MOFFITT CANCER CENTER & RES INST INC

  公开号：WO2017161119A1

  公开（公告）日：2017-09-21

  Disclosed are small molecules against cereblon to enhance effector T cell function. Methodos of making thes molecules and methods of using them to treat various disease states are also disclosed.

  披露了针对小脑蛋白以增强效应T细胞功能的小分子。还披露了制造这些分子的方法以及使用它们治疗各种疾病状态的方法。
• Small molecules against cereblon to enhance effector t cell function
  申请人：H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

  公开号：US11395820B2

  公开（公告）日：2022-07-26

  Disclosed are small molecules against cereblon to enhance effector T cell function. Methods of making these molecules and methods of using them to treat various disease states are also disclosed.

  所公开的是抗脑龙的小分子，可增强效应 T 细胞的功能。还公开了制造这些分子的方法以及用它们治疗各种疾病的方法。
• Pharmacologically active tripeptides and process for their synthesis
  申请人：ENIRICERCHE S.p.A.

  公开号：EP0199379B1

  公开（公告）日：1990-10-03
• SMALL MOLECULES AGAINST CEREBLON TO ENHANCE EFFECTOR T CELL FUNCTION
  申请人：H. Lee Moffitt Cancer Center And Research Institute, Inc.

  公开号：EP3429996A1

  公开（公告）日：2019-01-23
• US4053588A
  申请人：——

  公开号：US4053588A

  公开（公告）日：1977-10-11