(2S,5R,6R)-6-[[2-(2-aminophenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid | 2027-25-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S,5R,6R)-6-[[2-(2-aminophenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• CAS: 2027-25-0
• 化学式: C₁₆H₁₉N₃O₄S
• 分子量: 349.4
• InChiKey: WQLYKNDWIGWOMC-MBNYWOFBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  138
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• New use of alcaligenes faecalis penicillin G acylase
  申请人：GIST-BROCADES N.V.

  公开号：EP0638649A2

  公开（公告）日：1995-02-15

  The application of an Alcaligenes faecalis penicillin G acylase for the deacylation of some penicillanic and cephalosporanic acids and derivatives thereof have been provided.

  提供了一种粪阿卡菌青霉素 G酰化酶在一些青霉素酸和头孢菌素酸及其衍生物的脱乙酰化中的应用。
• Composition containing piperacillin, pharmaceutical formulation thereof and use thereof
  申请人：XIANGBEI WELMAN PHARMACEUTICAL CO., LTD.

  公开号：US11534438B2

  公开（公告）日：2022-12-27

  The present disclosure provides a piperacillin-containing composition, which further containing a certain proportion of ampicillin and sulbactam. The present disclosure further provides a pharmaceutical formulation thereof and the use thereof. The composition and pharmaceutical formulation of the present disclosure can inhibit the drug-resistant Acinetobacter baumannii , and particularly have therapeutic effects on the infection caused by Acinetobacter baumannii which is resistant to carbapenem or cefoperazone-sulbactam.

  本公开提供了一种含哌拉西林的组合物，其中进一步含有一定比例的氨苄西林和舒巴坦。本公开进一步提供了其药物制剂及其用途。本公开的组合物和药物制剂可抑制耐药的 鲍曼不动杆菌 鲍曼不动杆菌引起的感染有治疗作用。 鲍曼不动杆菌 对碳青霉烯类或头孢哌酮-舒巴坦类药物耐药的鲍曼不动杆菌引起的感染具有治疗作用。
• METHOD FOR TREATING SKIN DISORDERS WITH XANTHOPHYLLS
  申请人：Leonard Todd

  公开号：US20060122282A1

  公开（公告）日：2006-06-08

  The present invention provides for a method for treating a skin disorder in a mammal inflicted with a skin disorder. The present invention also provides for a method for retarding or reversing the loss of collagen fibers, abnormal changes in elastic fibers, or deterioration of small blood vessels in sundamaged mammalian skin. The present invention also provides for a method for exfoliating the skin surface of a mammal. The present invention also provides for a method for treating or preventing acne or a pimple in a mammal in need thereof. The methods include topically administering, to a mammal in need of such treatment, a composition that includes xanthophylls in a nontoxic amount, effective to treat the skin disorder.

  本发明提供了一种治疗患有皮肤病的哺乳动物的皮肤病的方法。本发明还提供了一种方法，用于延缓或逆转受损哺乳动物皮肤中胶原纤维的流失、弹性纤维的异常变化或小血管的恶化。本发明还提供了一种去除哺乳动物皮肤表面角质的方法。本发明还提供了一种治疗或预防哺乳动物痤疮或粉刺的方法。该方法包括向需要治疗的哺乳动物局部施用一种组合物，该组合物包括无毒量的黄绿素，可有效治疗皮肤疾病。
• LAMINATED BAG FOR PHARMACEUTICALS
  申请人：DSM Sinochem Pharmaceuticals Netherlands B.V.

  公开号：EP3094492A1

  公开（公告）日：2016-11-23
• Compositions useful to treat ocular neovascular diseases and macular degeneration
  申请人：Leonard Todd

  公开号：US20060134226A1

  公开（公告）日：2006-06-22

  The present invention provides a composition that includes: (a) xanthophylls; (b) vitamin C; (c) vitamin E; (d) zinc; and (e) copper. The present invention also provides a method of treating macular degeneration in a human, inhibiting angiogenesis in a human, preventing impairment of the vision or for improving impaired vision of a human whose eye has drusen, and/or treating a disease associated with ocular neovascularitis in a human. The methods include administering to a human in need of such treatment an effective amount of the composition of the present invention.