(S)-N-(2-Oxotetrahydrofuran-3-yl)propionamide | 478240-81-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-N-(2-Oxotetrahydrofuran-3-yl)propionamide
• 英文别名: N-[(3S)-2-oxooxolan-3-yl]propanamide
• CAS: 478240-81-2
• 化学式: C₇H₁₁NO₃
• 分子量: 157.17
• InChiKey: BHUQNXLFFUYMDZ-YFKPBYRVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] SYNTHETIC LIGANDS THAT MODULATE THE ACTIVITY OF THE RHLR QUORUM SENSING RECEPTOR<br/>[FR] LIGANDS SYNTHÉTIQUES MODULANT L'ACTIVITÉ DU RÉCEPTEUR DE DÉTECTION DU QUORUM RHLR
  申请人：WISCONSIN ALUMNI RES FOUND

  公开号：WO2017190116A1

  公开（公告）日：2017-11-02

  RhlR modulators including agonist and antagonists which are useful for modulating QS phenotypes in Gram-negative bacteria. Certain compounds of general formula A-W-HG having various carbocyclic ad heterocyclic head groups (HG) and various tail groups (A), where -W- is -CO-NH-, -SO2-NH-, -CO-NH-CH2-, or -SO2-NH-CH2- are RhlR agonists or antagonists. The compounds are useful in methods of modulating quorum sensing in Gram-negative bacteria, particularly in Pseudomonas. Compositions including certain RhlR modulators are useful for decreasing the virulence of Gram-negative bacteria. Pharmaceutical compositions comprising certain RhlR modulators are useful for treatment of infections of Gram-negative bacteria.

  RhlR调节剂包括激动剂和拮抗剂，对调节革兰氏阴性细菌中的QS表型有用。具有一般公式A-W-HG的某些化合物具有各种碳环和杂环头基团（HG）和各种尾基团（A），其中-W-为-CO-NH-，-SO2-NH-，-CO-NH-CH2-或-SO2-NH-CH2-是RhlR激动剂或拮抗剂。这些化合物在调节革兰氏阴性细菌中的群体感应方法中有用，特别是在铜绿假单胞菌中。包含某些RhlR调节剂的组合物有助于降低革兰氏阴性细菌的毒力。包含某些RhlR调节剂的药物组合物有助于治疗革兰氏阴性细菌感染。
• Synthetic ligands that modulate the activity of the RhlR quorum sensing receptor
  申请人：Wisconsin Alumni Research Foundation

  公开号：US11247976B2

  公开（公告）日：2022-02-15

  RhlR modulators including agonist and antagonists which are useful for modulating QS phenotypes in Gram-negative bacteria. Certain compounds of general formula A-W-HG having various carbocyclic ad heterocyclic head groups (HG) and various tail groups (A), where —W— is —CO—NH—, —SO2—NH—, —CO—NH—CH2—, or —SO2—NH—CH2— are RhlR agonists or antagonists. The compounds are useful in methods of modulating quorum sensing in Gram-negative bacteria, particularly in Pseudomonas. Compositions including certain RhlR modulators are useful for decreasing the virulence of Gram-negative bacteria. Pharmaceutical compositions comprising certain RhlR modulators are useful for treatment of infections of Gram-negative bacteria.

  RhlR 调节剂，包括激动剂和拮抗剂，可用于调节革兰氏阴性细菌的 QS 表型。通式 A-W-HG 的某些化合物具有各种碳环或杂环头基 (HG) 和各种尾基 (A)，其中 -W- 是 -CO-NH-、-SO2-NH-、-CO-NH-CH2- 或 -SO2-NH-CH2- 是 RhlR 激动剂或拮抗剂。这些化合物可用于调节革兰氏阴性细菌，特别是假单胞菌的法定量感应。包括某些 RhlR 调节剂的组合物有助于降低革兰氏阴性细菌的毒力。包含某些 RhlR 调节剂的药物组合物可用于治疗革兰氏阴性细菌感染。
• Synthetic Ligands that Modulate the Activity of the RhlR Quorum Sensing Receptor
  申请人：Wisconsin Alumni Research Foundation

  公开号：US20190144407A1

  公开（公告）日：2019-05-16

  RhlR modulators including agonist and antagonists which are useful for modulating QS phenotypes in Gram-negative bacteria. Certain compounds of general formula A-W-HG having various carbocyclic ad heterocyclic head groups (HG) and various tail groups (A), where —W— is —CO—NH—, —SO 2 —NH—, —CO—NH—CH 2 —, or —SO 2 —NH—CH 2 — are RhlR agonists or antagonists. The compounds are useful in methods of modulating quorum sensing in Gram-negative bacteria, particularly in Pseudomonas . Compositions including certain RhlR modulators are useful for decreasing the virulence of Gram-negative bacteria. Pharmaceutical compositions comprising certain RhlR modulators are useful for treatment of infections of Gram-negative bacteria.