methyl 8-benzyloxycarbonyl-2,2-dimethyl-5-oxo-2H,3H,5H-thiazolo<3,2-a>pyridine-3-carboxylate | 145904-19-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl 8-benzyloxycarbonyl-2,2-dimethyl-5-oxo-2H,3H,5H-thiazolo<3,2-a>pyridine-3-carboxylate
• 英文别名: 8-O-benzyl 3-O-methyl 2,2-dimethyl-5-oxo-3H-[1,3]thiazolo[3,2-a]pyridine-3,8-dicarboxylate
• CAS: 145904-19-4
• 化学式: C₁₉H₁₉NO₅S
• 分子量: 373.43
• InChiKey: UXBMLKJFWGLSQD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  98.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  methyl 8-benzyloxycarbonyl-3-isopropenyl-5-oxo-2-thia-4-azabicyclo<4.2.0>octa-6,8-diene-3-carboxylate 在 platinum(IV) oxide 氢气 作用下， 以 乙醇 为溶剂， 反应 6.0h， 以25%的产率得到methyl 8-benzyloxycarbonyl-2,2-dimethyl-5-oxo-2H,3H,5H-thiazolo<3,2-a>pyridine-3-carboxylate
  参考文献：
  名称：

  Reductive and catalytic rearrangements of 2-vinyl-1,3-thiazetidines

  摘要：

  2-Vinyl-1,3-thiazetidines have been shown to undergo a novel rearrangement to give thiazolidines such as 3 in good yield on hydrogenation using heterogeneous catalysts. When homogeneous catalysts are used, rearrangement takes a different course and thiazines such as 1 are formed. Borohydride reduction yields thiolactols such as 20.

  DOI：

  10.1016/s0040-4020(01)89044-x

文献信息

• Reductive and catalytic rearrangements of 2-vinyl-1,3-thiazetidines
  作者：Nigel K Capps、Gareth M Davies、David Loakes、Douglas W Young

  DOI：10.1016/s0040-4020(01)89044-x

  日期：——

  2-Vinyl-1,3-thiazetidines have been shown to undergo a novel rearrangement to give thiazolidines such as 3 in good yield on hydrogenation using heterogeneous catalysts. When homogeneous catalysts are used, rearrangement takes a different course and thiazines such as 1 are formed. Borohydride reduction yields thiolactols such as 20.