1-<4-Hydroxy-3-methoxy-phenyl>-hexan-3-on | 53172-00-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 1-<4-Hydroxy-3-methoxy-phenyl>-hexan-3-on
• 英文别名: (2)-Paradol；<2>-Paradol；1-(4-hydroxy-3-methoxy-phenyl)-hexan-3-one；1-(4-Hydroxy-3-methoxy-phenyl)-hexan-3-on；1-(4-Hydroxy-3-methoxyphenyl)hexan-3-one
• CAS: 53172-00-2
• 化学式: C₁₃H₁₈O₃
• 分子量: 222.284
• InChiKey: TWKXRMWIRZAHEI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  香草醛 在 palladium on activated charcoal 四氢吡咯 、 氢气 、 溶剂黄146 作用下， 生成 1-<4-Hydroxy-3-methoxy-phenyl>-hexan-3-on
  参考文献：
  名称：

  辛辣的化合物。第一部分。改进的对位异构体（烷基4-羟基-3-甲氧基苯乙基酮）的合成及其辛辣度评估

  摘要：

  同源系列的11个对位的多巴酚，其中一个[6]对位的多酚（正庚基4-羟基-3-甲氧基苯乙基酮）天然存在于砂仁砂仁（Zingiberaceae）的种子中（也称为天堂谷物） ，几内亚胡椒或Melegueta胡椒）已通过一种改良方法合成。该系列介绍了包括g​​lc行为在内的物理特性和刺激性评估实验。

  DOI：

  10.1039/p19720003001

文献信息

• Inhibitors Of Cognitive Decline
  申请人：Rishton Gilbert M.

  公开号：US20080193574A1

  公开（公告）日：2008-08-14

  Compounds that are central nervous system drug candidates for the treatment of cognitive decline and, more particularly, Alzheimer's disease are provided. Methods of treating, inhibiting, and/or abatement of cognitive decline and Alzheimer's disease with a derivative of ginger oil are also provided. Also provided is a method of conditioning biological extracts, such as a medicinal plant extract, by a reductive amination process to give nitrogen-containing derivatives.
• Inhibitors of cognitive decline
  申请人：Rishton Gilbert M.

  公开号：US20110111068A1

  公开（公告）日：2011-05-12

  Compounds that are central nervous system drug candidates for the treatment of cognitive decline and, more particularly, Alzheimer's disease are provided. Methods of treating, inhibiting, and/or abatement of cognitive decline and Alzheimer's disease with a derivative of ginger oil are also provided. Also provided is a method of conditioning biological extracts, such as a medicinal plant extract, by a reductive amination process to give nitrogen-containing derivatives.
• US7723377B2
  申请人：——

  公开号：US7723377B2

  公开（公告）日：2010-05-25
• Nomura; Hotta, Science Reports of the Tohoku University, Series 1: Physics, Chemistry, Astronomy, vol. 14, p. 136
  作者：Nomura、Hotta

  DOI：——

  日期：——
• Pungent compounds. Part I. An improved synthesis of the paradols (alkyl 4-hydroxy-3-methoxyphenethyl ketones) and an assessment of their pungency
  作者：H. D. Locksley、D. K. Rainey、T. A. Rohan

  DOI：10.1039/p19720003001

  日期：——

  of the homologous series of paradols, of which one, [6]paradol (n-heptyl 4-hydroxy-3-methoxyphenethyl ketone), occurs naturally in the seeds of Amomum melegueta Roscoe (Zingiberaceae)(otherwise known as Grains of Paradise, Guinea pepper, or Melegueta pepper), have been synthesised by an improved method. Physical characteristics, including g.l.c. behaviour, and pungency evaluation experiments are described

  同源系列的11个对位的多巴酚，其中一个[6]对位的多酚（正庚基4-羟基-3-甲氧基苯乙基酮）天然存在于砂仁砂仁（Zingiberaceae）的种子中（也称为天堂谷物） ，几内亚胡椒或Melegueta胡椒）已通过一种改良方法合成。该系列介绍了包括g​​lc行为在内的物理特性和刺激性评估实验。