Trimethyl glycine hydrochloride

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Trimethyl glycine hydrochloride
• 英文别名: carboxymethyl(trimethyl)azanium;hydrochloride
• 化学式: C5H13ClNO2+
• 分子量: 154.61
• InChiKey: HOPSCVCBEOCPJZ-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  37.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• PROCESS FOR PRODUCING 5-HYDROXYMETHYLFURFURAL IN THE PRESENCE OF AN INORGANIC DEHYDRATION AND A CHLORIDE SOURCE
  申请人：IFP Energies nouvelles

  公开号：US20200299250A1

  公开（公告）日：2020-09-24

  The invention relates to a process for converting a feedstock comprising at least one sugar into 5-hydroxymethylfurfural, wherein said feed is brought into contact with one or more inorganic dehydration catalysts and one or more chloride sources in the presence of at least one aprotic polar solvent alone or as a mixture, at a temperature of between 30° C. and 200° C., and at a pressure of between 0.1 MPa and 10 MPa.

  本发明涉及一种将至少一种糖为成分的原料转化为5-羟甲基糠醛的方法，其中该原料与一种或多种无机脱水催化剂和一种或多种氯化物源在至少一种无极性极性溶剂中单独或混合存在的情况下，在30℃至200℃的温度和0.1 MPa至10 MPa的压力下接触。
• PROCESS FOR PRODUCING 5-HYDROXYMETHYLFURFURAL IN THE PRESENCE OF AN ORGANIC DEHYDRATION CATALYST AND A CHLORIDE SOURCE
  申请人：IFP Energies nouvelles

  公开号：US20200290984A1

  公开（公告）日：2020-09-17

  The invention relates to a novel process for converting a feedstock comprising at least one sugar into 5-hydroxymethylfurfural, wherein said feedstock is brought into contact with one or more organic dehydration catalysts and one or more chloride sources in the presence of at least one aprotic polar solvent alone or as a mixture, at a temperature of between 30° C. and 200° C., and at a pressure of between 0.1 MPa and 10 MPa.

  本发明涉及一种将至少含有一种糖的原料转化为5-羟甲基糠醛的新型工艺，其中所述原料在至少一种无水极性溶剂或混合物的存在下，与一种或多种有机脱水催化剂和一种或多种氯化物源接触，在30℃至200℃的温度和0.1 MPa至10 MPa的压力下进行。
• PHARMACEUTICAL COMPOSITIONS AND DOSAGE FORMS
  申请人：Ignyta, Inc.

  公开号：US20190022089A1

  公开（公告）日：2019-01-24

  Disclosed herein are pharmaceutical compositions and dosage forms including N-[5-(3,5-difluorobenzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-2H-pyran-4-ylamino) benzamide that are useful in the treatment of subjects having cancer. The present disclosure also provides methods for preparing these pharmaceutical compositions and dosage forms, and methods of treating subjects having cancer utilizing the pharmaceutical compositions and dosage forms provided herein.

  本文披露了一种药物组合物和剂型，包括N-[5-(3,5-二氟苯基甲基)-1H-吲唑-3-基]-4-(4-甲基哌嗪-1-基)-2-(四氢-2H-吡喃-4-基氨基)苯甲酰胺，可用于治疗患有癌症的患者。本文还提供了制备这些药物组合物和剂型的方法，以及利用本文提供的药物组合物和剂型治疗患有癌症的患者的方法。
• Multifunctional transdermal dressing for wounds
  申请人：MATERIALS MODIFICATION INC.

  公开号：US10272172B2

  公开（公告）日：2019-04-30

  A multifunctional polymer-free clay products having a clay, a zwitterion, a silver compound, and, an analgesic. The multifunctional polymer-free clay product provides antimicrobial and pain relieving properties. Method of treatment of burns using the multifunctional polymer-free clay product having antimicrobial and pain relieving properties. Methods of preparing multifunctional polymer-free clay products having a clay, a zwitterion, a silver compound, and, an analgesic.

  一种不含聚合物的多功能粘土产品，含有一种粘土、一种齐聚物、一种银化合物和一种镇痛剂。该多功能无聚合物粘土产品具有抗菌和止痛特性。使用具有抗菌和止痛特性的多功能无聚合物粘土产品治疗烧伤的方法。制备具有粘土、齐聚物、银化合物和镇痛剂的多功能无聚合物粘土产品的方法。
• Pharmaceutical compositions and dosage forms
  申请人：Ignyta, Inc.

  公开号：US10398693B2

  公开（公告）日：2019-09-03

  Disclosed herein are pharmaceutical compositions and dosage forms including N-[5-(3,5-difluorobenzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-2H-pyran-4-ylamino) benzamide that are useful in the treatment of subjects having cancer. The present disclosure also provides methods for preparing these pharmaceutical compositions and dosage forms, and methods of treating subjects having cancer utilizing the pharmaceutical compositions and dosage forms provided herein.

  本文公开了包括N-[5-(3,5-二氟苄基)-1H-吲唑-3-基]-4-(4-甲基-哌嗪-1-基)-2-(四氢-2H-吡喃-4-基氨基)苯甲酰胺的药物组合物和剂型，这些药物组合物和剂型可用于治疗癌症患者。本公开还提供了制备这些药物组合物和剂型的方法，以及利用本文提供的药物组合物和剂型治疗癌症患者的方法。