[[(3-亚甲基环丁基)甲氧基]甲基]苯 | 583830-09-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: [[(3-亚甲基环丁基)甲氧基]甲基]苯
• 中文别名: 1-亚甲基-3-苄氧基甲基环丁烷
• 英文名称: {[(3-methylenecyclobutyl)methoxy]methyl}benzene
• 英文别名: 1-methylene-3-benzyloxymethyl-cyclobutane；{[(3-methylidenecyclobutyl)methoxy]methyl}benzene；(3-Methylenecyclobutyl)methoxymethylbenzene；(3-methylidenecyclobutyl)methoxymethylbenzene
• CAS: 583830-09-5
• 化学式: C₁₃H₁₆O
• 分子量: 188.269
• InChiKey: KIAUXIDOHJGVPS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  [[(3-亚甲基环丁基)甲氧基]甲基]苯 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 以95 %的产率得到5-[(benzyloxy)methyl]-1-oxaspiro[2.3]hexane
  参考文献：
  名称：

  2,2-二取代和2,2,3-三取代1,4-二恶烷衍生结构单元的合成

  摘要：

  描述了一种制备 2,2-二取代和 2,2,3-三取代 1,4-二恶烷衍生结构单元的方法。该反应顺序以带有附加苄氧基的二甲基或螺环丁基取代的环氧乙烷作为起始原料开始。1,4-二恶烷环构建的关键步骤包括用乙二醇单锂盐进行环氧乙烷开环，然后对所得二醇进行两步环化。该方法的实用性通过2,2-二甲基-1,4-二恶烷和5,8-二氧杂螺[3.5]壬烷结构单元的多克制备（最多300克；最终产品的平均规模为30克）来证明，即羧酸、醇、胺、醛、酮和溴化物。通过制备含 1,4-二恶烷的乙炔的选定实例，显示了其他合成可能性，

  DOI：

  10.1055/a-2092-9205
• 作为产物：
  描述：

  3-((苄氧基)甲基)环丁酮 在 potassium tert-butylate 作用下， 以 1,4-二氧六环 为溶剂， 反应 3.5h， 以63%的产率得到[[(3-亚甲基环丁基)甲氧基]甲基]苯
  参考文献：
  名称：

  WO2006/63281

  摘要：

  公开号：

文献信息

• [EN] PHOSPHODIESTARASE INHIBITORS<br/>[FR] INHIBITEURS DE PHOSPHODIESTÉRASES
  申请人：RANBAXY LAB LTD

  公开号：WO2010046791A1

  公开（公告）日：2010-04-29

  The present invention relates to phosphodiesterase (PDE) type 4, phosphodiesterase (PDE) type 7 and dual PDE type 4 /PDE type 7 inhibitors. Compounds disclosed herein can be useful in the treatment, prevention, inhibition or suppression of CNS diseases, for example, multiple sclerosis; various pathological conditions such as diseases affecting the immune system, including AIDS, rejection of transplant, auto-immune disorders such as T-cell related diseases, for example, rheumatoid arthritis; inflammatory diseases such as respiratory inflammation diseases including chronic obstructive pulmonary disease (COPD), asthma, bronchitis, allergic rhinitis, adult respiratory distress syndrome (ARDS) and other inflammatory diseases including but not limited to psoriasis, shock, atopic dermatitis, eosinophilic granuloma, allergic conjunctivitis, osteoarthritis; gastrointestinal inflammation diseases such as Crohn's disease, colitis, pancreatitis as well as different types of cancers including leukaemia; especially in humans. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as PDE type 4, PDE type 7 and dual PDE type 4 /PDE type 7 inhibitors are provided.

  本发明涉及磷酸二酯酶（PDE）类型4、磷酸二酯酶（PDE）类型7以及双重PDE类型4/PDE类型7抑制剂。本文披露的化合物可用于治疗、预防、抑制或抑制中枢神经系统疾病，例如多发性硬化症；各种影响免疫系统的疾病，包括艾滋病、移植排斥、自身免疫疾病如T细胞相关疾病，例如类风湿性关节炎；呼吸道炎症性疾病如慢性阻塞性肺疾病（COPD）、哮喘、支气管炎、过敏性鼻炎、成人呼吸窘迫综合症（ARDS）以及其他炎症性疾病，包括但不限于牛皮癣、休克、特应性皮炎、嗜酸性肉芽肿、过敏性结膜炎、骨关节炎；肠道炎症性疾病如克罗恩病、结肠炎、胰腺炎以及不同类型的癌症，包括白血病；尤其是在人类中。提供了披露化合物的制备过程、含有披露化合物的药物组合物以及它们作为PDE类型4、PDE类型7和双重PDE类型4/PDE类型7抑制剂的用途。
• 2' and 3'- substituted cyclobutyl nucleoside analogs for the treatment of viral infections and abnormal cellular proliferation
  申请人：Liotta C. Dennis

  公开号：US20060223835A1

  公开（公告）日：2006-10-05

  Provided are cyclobutyl nucleosides and methods for their use in treatment of infections including Retroviridae (including HIV), Hepadnaviridae (including HBV), or Flaviviridae (including BVDV and HCV) infection, or conditions related to abnormal cellular proliferation, in a host, including animals, and especially humans.

  提供环丁基核苷和它们的使用方法，用于治疗感染，包括Retroviridae（包括HIV），Hepadnaviridae（包括HBV）或Flaviviridae（包括BVDV和HCV）感染，或与异常细胞增殖有关的病症，在宿主（包括动物，尤其是人类）中使用。
• 2′ and 3′-substituted cyclobutyl nucleoside analogs for the treatment viral infections and abnormal cellular proliferation
  申请人：Emory University

  公开号：US08114994B2

  公开（公告）日：2012-02-14

  Provided are cyclobutyl nucleosides and methods for their use in treatment of infections including Retroviridae (including HIV), Hepadnaviridae (including HBV), or Flaviviridae (including BVDV and HCV) infection, or conditions related to abnormal cellular proliferation, in a host, including animals, and especially humans.

  提供了环丁基核苷和其在治疗感染，包括逆转录病毒科（包括HIV）、乙型肝炎病毒科（包括HBV）或黄病毒科（包括BVDV和HCV）感染，或与异常细胞增殖相关的疾病条件中的应用方法，适用于宿主，包括动物，尤其是人类。
• PHOSPHODIESTARASE INHIBITORS
  申请人：Rudra Sonali

  公开号：US20120004201A1

  公开（公告）日：2012-01-05

  The present invention relates to phosphodiesterase (PDE) type 4, phosphodiesterase (PDE) type 7 and dual PDE type 4/PDE type 7 inhibitors. Compounds disclosed herein can be useful in the treatment, prevention, inhibition or suppression of CNS diseases, for example, multiple sclerosis; various pathological conditions such as diseases affecting the immune system, including AIDS, rejection of transplant, auto-immune disorders such as T-cell related diseases, for example, rheumatoid arthritis; inflammatory diseases such as respiratory inflammation diseases including chronic obstructive pulmonary disease (COPD), asthma, bronchitis, allergic rhinitis, adult respiratory distress syndrome (ARDS) and other inflammatory diseases including but not limited to psoriasis, shock, atopic dermatitis, eosinophilic granuloma, allergic conjunctivitis, osteoarthritis; gastrointestinal inflammation diseases such as Crohn's disease, colitis, pancreatitis as well as different types of cancers including leukaemia; especially in humans. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as PDE type 4, PDE type 7 and dual PDE type 4/PDE type 7 inhibitors are provided.

  本发明涉及磷酸二酯酶（PDE）类型4、磷酸二酯酶（PDE）类型7和双重PDE类型4/PDE类型7抑制剂。本文所披露的化合物可用于治疗、预防、抑制或抑制中枢神经系统疾病，例如多发性硬化症；各种影响免疫系统的病理条件，包括艾滋病、移植排斥、自身免疫性疾病如T细胞相关疾病，例如类风湿性关节炎；炎症性疾病如呼吸道炎症性疾病，包括慢性阻塞性肺疾病（COPD）、哮喘、支气管炎、过敏性鼻炎、成人呼吸窘迫综合症（ARDS）和其他炎症性疾病，包括但不限于牛皮癣、休克、特应性皮炎、嗜酸性肉芽肿、过敏性结膜炎、骨关节炎；胃肠道炎症性疾病，如克罗恩病、结肠炎、胰腺炎以及不同类型的癌症，包括白血病；特别是在人类中。提供了制备所披露的化合物的过程、含有所披露的化合物的制药组合物以及它们作为PDE类型4、PDE类型7和双重PDE类型4/PDE类型7抑制剂的用途。
• 2′ and 3′-substituted cyclobutyl nucleoside analogs for the treatment of viral infections and abnormal cellular proliferation
  申请人：Emory University

  公开号：US07495006B2

  公开（公告）日：2009-02-24

  Provided are cyclobutyl nucleosides and methods for their use in treatment of infections including Retroviridae (including HIV), Hepadnaviridae (including HBV), or Flaviviridae (including BVDV and HCV) infection, or conditions related to abnormal cellular proliferation, in a host, including animals, and especially humans.

  提供了环丁基核苷和它们在治疗感染，包括Retroviridae（包括HIV），Hepadnaviridae（包括HBV）或Flaviviridae（包括BVDV和HCV）感染或与异常细胞增殖有关的病症方面的使用方法，适用于宿主，包括动物，尤其是人类。