olsalazine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: olsalazine
• 英文别名: 5-[2-(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)hydrazinyl]-2-hydroxybenzoic acid
• 化学式: C₁₄H₁₀N₂O₆
• 分子量: 302.243
• InChiKey: ULGVHUUBIHTFAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  136
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  醌茜素 、 olsalazine 以 甲醇 为溶剂， 生成 olsalazine
  参考文献：
  名称：

  New FI-Spectrophotometric Methods for Determination of Olsalazine in Pure and Pharmaceutical Preparations via Complexation with Quinalizarin Reagent

  摘要：

  本文描述了一种新的、快速且灵敏的流动注射分析（FIA）-分光光度法，用于测定水溶液和药物制剂中微量奥沙拉嗪。该方法基于奥沙拉嗪和喹吖啶醇在甲醇中的电荷转移反应，形成一种稳定的、最大吸收波长为570 nm的深橙红色甲醇可溶性产物。在浓度范围为0.5-45和10-150 μg mL-1时，符合比尔定律，批次法和流动注射法的检测限分别为0.125和2.480 μg mL-1。仔细研究了影响有色产物灵敏度和稳定性的最佳条件（化学和物理）实验参数。优化的流动注射分析系统能够以52 h-1的速度测定奥沙拉嗪。药物制剂中常用的添加剂不会干扰所提出的方法。该方法成功地应用于测定剂型中的奥沙拉嗪。结果与英国药典方法进行了统计学比较。

  DOI：

  10.14233/ajchem.2015.19306

文献信息

• New FI-Spectrophotometric Methods for Determination of Olsalazine in Pure and Pharmaceutical Preparations via Complexation with Quinalizarin Reagent
  作者：Bushra B. Qassim

  DOI：10.14233/ajchem.2015.19306

  日期：——

  A new, rapid and sensitive flow injection analysis (FIA)-spectrophotometric methods for the determination of trace amounts of olsalazine in aqueous solution and in pharmaceutical preparations are described. The methods are based on the charge transfer reaction between olsalazine and quinalizarin in methanol to form an intense reddish orange, methanol-soluble product that is stable and has a maximum absorption at 570 nm. Beer’s law was obeyed over the concentration range of 0.5-45 and 10-150 μg mL-1 with the detection limits of 0.125 and 2.480 μg mL-1 for batch and flow injection methods, respectively. The optimum conditions (chemical and physical) experimental parameters affecting on the sensitivity and stability of the coloured product are carefully investigated. The optimized flow injection analysis system is able to determine olsalazine through put 52 h-1. Common exicpients used as additives in drugs formulations do not interfered in the proposed methods. The methods were applied successfully to the determination of olsalazine in dosage forms. The results were compared statistically with the British pharmacopoeia method.

  本文描述了一种新的、快速且灵敏的流动注射分析（FIA）-分光光度法，用于测定水溶液和药物制剂中微量奥沙拉嗪。该方法基于奥沙拉嗪和喹吖啶醇在甲醇中的电荷转移反应，形成一种稳定的、最大吸收波长为570 nm的深橙红色甲醇可溶性产物。在浓度范围为0.5-45和10-150 μg mL-1时，符合比尔定律，批次法和流动注射法的检测限分别为0.125和2.480 μg mL-1。仔细研究了影响有色产物灵敏度和稳定性的最佳条件（化学和物理）实验参数。优化的流动注射分析系统能够以52 h-1的速度测定奥沙拉嗪。药物制剂中常用的添加剂不会干扰所提出的方法。该方法成功地应用于测定剂型中的奥沙拉嗪。结果与英国药典方法进行了统计学比较。