1,3-dimethoxy-5-(styryloxy)benzene | 960069-10-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,3-dimethoxy-5-(styryloxy)benzene
• 英文别名: 1,3-dimethoxy-5-[(E)-2-phenylethenoxy]benzene
• CAS: 960069-10-7
• 化学式: C₁₆H₁₆O₃
• 分子量: 256.301
• InChiKey: WWKDQCVZFWUNAS-CMDGGOBGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3,5-二甲氧基苯酚 、 E-styryl iodide 在 copper(l) iodide 、 2-(2-吡啶)-苯并咪唑 、 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 7.08h， 以93%的产率得到1,3-dimethoxy-5-(styryloxy)benzene
  参考文献：
  名称：

  一种高效多功能配体在铜催化乙烯基卤化物与 N-杂环和酚的交叉偶联反应中的首次应用

  摘要：

  2-Pyridin-2-yl-1H-benzoimidazole L3 是一种新型、高效、多功能的双齿 N 供体配体，适用于铜催化形成乙烯基 CN 和 CO 键。这种廉价且易于制备的配体促进了铜催化的烯基溴化物和碘化物与N-杂环和酚的交叉偶联反应，以良好至极好的收率提供所需的交叉偶联产物，并完全保留立体化学。这种方法特别值得注意，因为它的效率，即温和的反应条件、低催化剂负载、简单、多功能和优异的官能团耐受性。

  DOI：

  10.1021/ol9026446

文献信息

• ANTI-INFECTIVE AGENTS AND METHODS OF USE
  申请人：Monte Aaron

  公开号：US20070292545A1

  公开（公告）日：2007-12-20

  The present invention provides compounds and methods of using of the compounds as anti-infective agents. In a preferred embodiment, the present invention provides wherein R 1 is not H when R 2 is H and R 2 is not H when R 1 is H, further wherein R 1 is CH (2n+1) O, wherein n is 1-10; wherein R 2 is OH or CH (2n+1) O, wherein n is 1-10; and wherein A, B and R 1 , R 2 , R 5 , R 6 , and R 7 are independently selected from a group consisting of H, alkyl and aryl groups and R 11 is an alkyl or an aryl group

  本发明提供化合物及其使用方法作为抗感染剂。在一种优选实施例中，本发明提供其中R1不是H时，R2是H，且R2不是H时，R1是H，进一步地，其中R1是CH（2n+1）O，其中n为1-10；其中R2是OH或CH（2n+1）O，其中n为1-10；以及其中A、B和R1、R2、R5、R6和R7分别独立地选自H、烷基和芳基基团，而R11是烷基或芳基基团。
• Broad Spectrum Gram-Positive Antimicrobials and Anthelmintics with Efficacy Against Drug-Resistant Strains and Mycobacterium Species
  申请人：Monte Aaron P.

  公开号：US20110092578A1

  公开（公告）日：2011-04-21

  The present invention provides compounds and methods of using of the compounds as anti-infective and anthelminitc agents. In a preferred embodiment, the present invention provides the following compound of Formula III: wherein: R 1 is not H when R 2 is H and R 2 is not H when R 1 is H, further wherein R 1 is OH or CH (2n+1) O, wherein n is 1-10; R 2 is OH or CH (2n+1) O, where n is 1-10; W is alkyl, phenyl, halophenyl, pyridyl, piperidyl, or a substituted or unsubstituted aryl group, including unsubstituted and substituted aromatic heterocycles; and L is an optional linker or linking group selected from O, S, NH, CF 2 , or CH 2 , and x=0 or 1, i.e., if x=0, no linking group is present.

  本发明提供了化合物及其使用方法，作为抗感染和驱虫剂。在一种优选实施例中，本发明提供以下III式化合物：其中：当R2为H时，R1不是H，当R1为H时，R2不是H，进一步地，其中R1为OH或CH（2n+1）O，其中n为1-10；R2为OH或CH（2n+1）O，其中n为1-10；W为烷基、苯基、卤代苯基、吡啶基、哌啶基或取代或未取代的芳基基团，包括未取代和取代的芳香杂环；L是可选的连接或连接基，选择自O、S、NH、CF2或CH2，x=0或1，即如果x=0，则不存在连接基。
• New classes of Gram-positive selective antibacterials: Inhibitors of MRSA and surrogates of the causative agents of anthrax and tuberculosis
  作者：M. Shahjahan Kabir、Kathleen Engelbrecht、Rebecca Polanowski、Sarah M. Krueger、Rachel Ignasiak、Marc Rott、William R. Schwan、Mary E. Stemper、Kurt D. Reed、David Sherman、James M. Cook、Aaron Monte

  DOI：10.1016/j.bmcl.2008.09.085

  日期：2008.11

  An antimicrobial phenolic stilbene, (E)-3-hydroxy-5-methoxystilbene, 1 was recently isolated from the leaves of Comptonia peregrina (L.) Coulter and shown to possess inhibitory activity against several Gram-positive bacteria, including isolates of methicillin-resistant Staphylococcus aureus (MRSA), Mycobacterium bovis BCG, and avirulent Bacillus anthracis (Sterne strain), among others. These results prompted the design and synthesis of two new classes of compounds, phenoxystyrenes and phenothiostyrenes, as analogs of the natural antimicrobial stilbene. These and additional stilbenoid analogs were synthesized using new, efficient, copper-mediated coupling strategies. Minimum inhibitory concentration (MIC) antimicrobial assays were performed on all compounds prepared. These preliminary structure-activity relationship studies indicated that both new classes of synthetic analogs, as well as the stilbenes, show promising activity against Gram-positive bacteria when at least one phenolic moiety is present, but not when absent. The potencies of the phenolic phenoxystyrenes and phenothiostyrenes were found to be comparable to those of the phenolic stilbenes tested. (C) 2008 Elsevier Ltd. All rights reserved.
• US8530512B2
  申请人：——

  公开号：US8530512B2

  公开（公告）日：2013-09-10
• First Application of an Efficient and Versatile Ligand for Copper-Catalyzed Cross-Coupling Reactions of Vinyl Halides with <i>N</i>-Heterocycles and Phenols
  作者：M. Shahjahan Kabir、Michael Lorenz、Ojas A. Namjoshi、James M. Cook

  DOI：10.1021/ol9026446

  日期：2010.2.5

  2-Pyridin-2-yl-1H-benzoimidazole L3 is presented as a new, efficient, and versatile bidentate N-donor ligand suitable for the copper-catalyzed formation of vinyl C−N and C−O bonds. This inexpensive and easily prepared ligand facilitates copper-catalyzed cross-coupling reactions of alkenyl bromides and iodides with N-heterocycles and phenols to afford the desired cross-coupled products in good to excellent

  2-Pyridin-2-yl-1H-benzoimidazole L3 是一种新型、高效、多功能的双齿 N 供体配体，适用于铜催化形成乙烯基 CN 和 CO 键。这种廉价且易于制备的配体促进了铜催化的烯基溴化物和碘化物与N-杂环和酚的交叉偶联反应，以良好至极好的收率提供所需的交叉偶联产物，并完全保留立体化学。这种方法特别值得注意，因为它的效率，即温和的反应条件、低催化剂负载、简单、多功能和优异的官能团耐受性。