(S)-3-hydroxytridecan-4-one | 1004296-82-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (S)-3-hydroxytridecan-4-one
• 英文别名: (3S)-3-hydroxytridecan-4-one
• CAS: 1004296-82-5
• 化学式: C₁₃H₂₆O₂
• 分子量: 214.34
• InChiKey: OWRHIIOUJRCXDH-LBPRGKRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  15
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] HETEROCYCLE ANALOGS OF CAI-1 AS AGONISTS OF QUORUM SENSING IN VIBRIO<br/>[FR] ANALOGUES HÉTÉROCYCLIQUES DE CAI-1 EN TANT QU'AGONISTES DE LA DÉTECTION DU QUORUM CHEZ VIBRIO
  申请人：UNIV PRINCETON

  公开号：WO2015026796A1

  公开（公告）日：2015-02-26

  A structurally distinct and potent series of synthetic small molecule activators of Vibrio cholerae quorum sensing have been chemically synthesized. The small molecule activators reduce virulence in V. cholerae. Acyl pyrrole molecules displayed strong potency and stability, particularly l-(1H-pyrrol-3-yl)decan-l-one.

  一系列结构独特且强效的合成小分子活化剂已经化学合成，用于强化霍乱弧菌的群体感应。这些小分子活化剂降低了霍乱弧菌的毒力。酰基吡咯分子表现出很强的效力和稳定性，尤其是l-(1H-吡咯-3-基)癸酮。
• BROAD SPECTRUM PRO-QUORUM-SENSING MOLECULES AS INHIBITORS OF VIRULENCE IN VIBRIOS
  申请人：THE TRUSTEES OF PRINCETON UNIVERSITY

  公开号：US20150126474A1

  公开（公告）日：2015-05-07

  Using a whole-cell high-throughput screen, eleven molecules were identified that activate V. cholerae quorum sensing (QS). Eight molecules are receptor agonists and three molecules are antagonists of LuxO, the central NtrC-type response regulator that controls the global V. cholerae QS cascade. Pro-QS molecules are used for the development of novel anti-infectives.

  使用全细胞高通量筛选，鉴定出了11种分子，可以激活V. cholerae的群体感应（QS）。其中8种分子是受体激动剂，3种分子是LuxO的拮抗剂，LuxO是控制全局V. cholerae QS级联反应的中央NtrC型响应调节器。Pro-QS分子可用于开发新型抗感染药物。
• HETEROCYCLE ANALOGS OF CAI-1 AS AGONISTS OF QUORUM SENSING IN VIBRIO
  申请人：BASSLER Bonnie L.

  公开号：US20160200678A1

  公开（公告）日：2016-07-14

  A structurally distinct and potent series of synthetic small molecule activators of Vibrio cholerae quorum sensing have been chemically synthesized. The small molecule activators reduce virulence in V. cholerae . Acyl pyrrole molecules displayed strong potency and stability, particularly 1-(1H-pyrrol-3-yl)decan-1-one.

  一种结构独特且有效的合成小分子激活剂系列已经化学合成，可以激活霍乱弧菌的感应系统。这些小分子激活剂可以减少霍乱弧菌的毒力。酰基吡咯分子表现出强大的效力和稳定性，特别是1-(1H-吡咯-3-基)癸酮。
• Heterocycle analogs of CAI-1 as agonists of quorum sensing in vibrio
  申请人：The Trustees of Princeton University

  公开号：US10285978B2

  公开（公告）日：2019-05-14

  A structurally distinct and potent series of synthetic small molecule activators of Vibrio cholerae quorum sensing have been chemically synthesized. The small molecule activators reduce virulence in V. cholerae. Acyl pyrrole molecules displayed strong potency and stability, particularly 1-(1H-pyrrol-3-yl)decan-1-one.

  我们用化学方法合成了一系列结构独特、效力强大的霍乱弧菌法定人数感应合成小分子激活剂。这些小分子激活剂降低了霍乱弧菌的毒力。酰基吡咯分子显示出很强的效力和稳定性，尤其是 1-（1H-吡咯-3-基）癸-1-酮。
• Recombinant expression system that senses pathogenic microorganisms
  申请人：Nanyang Technological University

  公开号：US10435697B2

  公开（公告）日：2019-10-08

  The present invention relates to a recombinant expression system comprising at least: (i) a first nucleotide sequence encoding for at least one protein of a quorum sensing system capable of detecting the presence, amount or both of a microorganism of interest by forming a complex with a marker molecule indicating the presence of said microorganism; (ii) a second nucleotide sequence encoding for at least one antimicrobial peptide, wherein the at least one antimicrobial peptide is effective against the microorganism of interest detected by the at least one protein encoded by the first nucleotide sequence, (iii) a third nucleotide sequence encoding for a genetic inverter that inhibits expression of the second nucleotide sequence, wherein the genetic inverter is under control of an inducible promoter and wherein the inducible promoter is induced if the complex of the at least one protein encoded by the first nucleotide sequence and the marker molecule indicating the presence of said microorganism is below a threshold concentration and is not induced if the complex of the at least one protein encoded by the first nucleotide sequence and the marker molecule indicating the presence of said microorganism exceeds a threshold concentration. Further encompassed is the use of the expression system and cells comprising the expression system of the invention.

  本发明涉及一种重组表达系统，该系统至少包括(i) 第一核苷酸序列，编码至少一种定量感应系统蛋白质，该蛋白质能够通过与指示所述微生物存在的标记分子形成复合物来检测所述微生物的存在、数量或两者；(ii) 第二核苷酸序列，编码至少一种抗菌肽，其中至少一种抗菌肽对第一核苷酸序列编码的至少一种蛋白质检测到的相关微生物有效； (iii) 第三核苷酸序列，编码抑制第二核苷酸序列表达的遗传变换器、其中，遗传反转器受可诱导启动子控制，如果第一核苷酸序列编码的至少一种蛋白质和指示所述微生物存在的标记分子的复合物低于阈值浓度，则可诱导启动子被诱导，如果第一核苷酸序列编码的至少一种蛋白质和指示所述微生物存在的标记分子的复合物超过阈值浓度，则可诱导启动子不被诱导。还包括本发明表达系统和包含本发明表达系统的细胞的用途。