phenylmethyl 3-O-(p-nitrobenzoyl)-4-O-[(2S,6R)-3,6-dihydro-6-methyl-2H-pyran-2-yl]-β-D-olivopyranoside | 1030632-25-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: phenylmethyl 3-O-(p-nitrobenzoyl)-4-O-[(2S,6R)-3,6-dihydro-6-methyl-2H-pyran-2-yl]-β-D-olivopyranoside
• 英文别名: [(2R,3R,4R,6R)-2-methyl-3-[[(2S,6R)-6-methyl-3,6-dihydro-2H-pyran-2-yl]oxy]-6-phenylmethoxyoxan-4-yl] 4-nitrobenzoate
• CAS: 1030632-25-7
• 化学式: C₂₆H₂₉NO₈
• 分子量: 483.518
• InChiKey: FIASLRWVNALONC-YFEQJULXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  109
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  phenylmethyl 3-O-(p-nitrobenzoyl)-4-O-[(2S,6R)-3,6-dihydro-6-methyl-2H-pyran-2-yl]-β-D-olivopyranoside 在 甲醇 、 potassium carbonate 作用下， 反应 2.0h， 以98%的产率得到phenylmethyl 4-O-[(2S,6R)-3,6-dihydro-6-methyl-2H-pyran-2-yl]-β-D-olivopyranoside
  参考文献：
  名称：

  De Novo Synthesis of the Trisaccharide Subunit of Landomycins A and E

  摘要：

  A highly enantio- and diastereoselective synthesis of alpha-L-rhodinose, beta-D-olivose as well as the trisaccharide portion of landomycin A from achiral acetyl furan has been developed. The key transformations include the palladium-catalyzed glycosylation, Myers' reductive rearrangement, diastereoselective dihydroxylation, and regioselective Mitsunobu inversion. A Mitsunobu reaction on a six member ring cis-1,2-diol was found to chemoselectively discriminate between equatorial and axial alcohols and to stereoselectively convert cis-1,2-diol into ant 1,2-diol.

  DOI：

  10.1021/ol800697k
• 作为产物：
  描述：

  phenylmethyl 3-O-(p-nitrobenzoyl)-4-O-[(2R,6R)-5,6-dihydro-5-hydroxy-6-methyl-2H-pyran-2-yl]-β-D-olivopyranoside 在 N-甲基吗啉 、 2-硝基苯磺酰肼 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以85%的产率得到phenylmethyl 3-O-(p-nitrobenzoyl)-4-O-[(2S,6R)-3,6-dihydro-6-methyl-2H-pyran-2-yl]-β-D-olivopyranoside
  参考文献：
  名称：

  De Novo Synthesis of the Trisaccharide Subunit of Landomycins A and E

  摘要：

  A highly enantio- and diastereoselective synthesis of alpha-L-rhodinose, beta-D-olivose as well as the trisaccharide portion of landomycin A from achiral acetyl furan has been developed. The key transformations include the palladium-catalyzed glycosylation, Myers' reductive rearrangement, diastereoselective dihydroxylation, and regioselective Mitsunobu inversion. A Mitsunobu reaction on a six member ring cis-1,2-diol was found to chemoselectively discriminate between equatorial and axial alcohols and to stereoselectively convert cis-1,2-diol into ant 1,2-diol.

  DOI：

  10.1021/ol800697k

文献信息

• De Novo Synthesis of the Trisaccharide Subunit of Landomycins A and E
  作者：Maoquan Zhou、George A. O’Doherty

  DOI：10.1021/ol800697k

  日期：2008.6.5

  A highly enantio- and diastereoselective synthesis of alpha-L-rhodinose, beta-D-olivose as well as the trisaccharide portion of landomycin A from achiral acetyl furan has been developed. The key transformations include the palladium-catalyzed glycosylation, Myers' reductive rearrangement, diastereoselective dihydroxylation, and regioselective Mitsunobu inversion. A Mitsunobu reaction on a six member ring cis-1,2-diol was found to chemoselectively discriminate between equatorial and axial alcohols and to stereoselectively convert cis-1,2-diol into ant 1,2-diol.