MMP-13 selective alpha-sulfone hydroxamates: Identification of selective P1′ amides
作者:Yvette M. Fobian、John N. Freskos、Thomas E. Barta、Louis J. Bedell、Robert Heintz、Darren J. Kassab、James R. Kiefer、Brent V. Mischke、John M. Molyneaux、Patrick Mullins、Grace E. Munie、Daniel P. Becker
DOI:10.1016/j.bmcl.2011.03.095
日期:2011.5
Continuing our interest in designing compounds preferentially potent and selective for MMP-13, we report on a series of hydroxamic acids with a flexible amide P1' substituents. We identify an amide which spares both MMP-1 and -14, and shows >500 fold selectivity for MMP-13 versus MMP-2 and -8. (C) 2011 Elsevier Ltd. All rights reserved.