Octanoic acid, 8,8a(2)-[1,2-ethanediylbis(methylimino)]bis[8-oxo- | 149648-54-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Octanoic acid, 8,8a(2)-[1,2-ethanediylbis(methylimino)]bis[8-oxo-
• 英文别名: 8-[2-[7-carboxyheptanoyl(methyl)amino]ethyl-methylamino]-8-oxooctanoic acid
• CAS: 149648-54-4
• 化学式: C₂₀H₃₆N₂O₆
• 分子量: 400.5
• InChiKey: ZPBIPEKGLGVMMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  28
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  115
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS
  申请人：Cereno Scientific AB

  公开号：US20210060014A1

  公开（公告）日：2021-03-04

  There is provided a compound which is a histone deacetylase (HDAC) inhibitor, or a pharmaceutically acceptable ester, amide, solvate or salt thereof, for use in: (I) treating or preventing a pathological condition associated with excess fibrin deposition and/or thrombus formation; and/or (II) potentiating the degradation of fibrin deposits and preventing such deposits associated with pathological conditions or which may lead to such conditions, wherein the HDAC inhibitor, and the dose thereof, is as described in the description. There is also provided valproic acid, or a pharmaceutically acceptable salt thereof, for use in improving or normalizing endogenous fibrinolysis impaired by local or systemic inflammation.