Malonic acid bis-(2,5-dioxo-pyrrolidin-1-yl) ester | 30364-59-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Malonic acid bis-(2,5-dioxo-pyrrolidin-1-yl) ester
• 英文别名: Di(N-succinimidyl) malonate；bis(2,5-dioxopyrrolidin-1-yl) propanedioate
• CAS: 30364-59-1
• 化学式: C₁₁H₁₀N₂O₈
• 分子量: 298.209
• InChiKey: BFZPHDNANLUXSI-UHFFFAOYSA-N

物化性质

• 沸点：
  452.8±55.0 °C(Predicted)
• 密度：
  1.65±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  127
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  6-氨基-6-脱氧-alpha-D-吡喃葡萄糖基6-氨基-6-脱氧-alpha-D-吡喃葡萄糖苷 、 Malonic acid bis-(2,5-dioxo-pyrrolidin-1-yl) ester 以 水 、 二甲基亚砜 为溶剂， 生成
  参考文献：
  名称：

  CN116199726

  摘要：

  公开号：

文献信息

• NEW ANTIBODY DRUG CONJUGATES (ADCS) AND THE USE THEREOF
  申请人：SEATTLE GENETICS, INC.

  公开号：US20150023989A1

  公开（公告）日：2015-01-22

  The present application relates to new antibody drug conjugates (ADCs) of N,N dialkylauristatins directed against the target FGFR2, drug metabolites of said ADCs, a method for producing said ADCs, the use of said ADCs for the treatment and/or prevention of illnesses as well as the use of said ADCs for producing pharmaceuticals for the treatment and/or prevention of illnesses, particularly of hyperproliferative and/or angiogenic diseases such as carcinosis. Such treatments can be carried out as monotherapy or in combination with other pharmaceuticals or additional therapeutic measures.

  本申请涉及针对FGFR2靶点的新抗体药物结合物（ADCs），所述ADCs的药物代谢产物，生产所述ADCs的方法，利用所述ADCs治疗和/或预防疾病以及利用所述ADCs生产用于治疗和/或预防疾病的药物，特别是治疗高增殖和/或血管生成性疾病如癌症。这种治疗可以作为单药疗法进行，也可以与其他药物或额外的治疗措施结合使用。
• [EN] NUCLEOPHILE-TRIGGERED DEGRADBLE MATERIALS AND METHODS OF MAKING AND USING THE SAME<br/>[FR] MATÉRIAUX DÉGRADABLES À DÉGRADATION DÉCLENCHÉE PAR NUCLÉOPHILE ET LEURS PROCÉDÉS DE FABRICATION ET D'UTILISATION
  申请人：GEORGIA TECH RES INST

  公开号：WO2016090060A1

  公开（公告）日：2016-06-09

  Disclosed herein are degradable materials comprising the reaction product of an oxanorbomadiene crosslinker or derivative thereof and a multivalent nucleophile-terminated compound, wherein the reaction product is a degradable elastic solid capable of entraining cargo. Also disclosed herein are degradable materials comprising a polymeric and hyperbranched crosslinked material made with oxanorbomadiene linkage that can be activated for cleavage at a predetermined rate by addition of a nucleophile. Also disclosed herein are methods of making and using the same.

  本文披露了一种可降解材料，其包括氧杂环戊二烯交联剂或其衍生物与多价亲核末端化合物的反应产物，所述反应产物是一种可降解的弹性固体，能够包裹货物。本文还披露了一种由氧杂环戊二烯键合制成的聚合物和超支化交联材料，可通过添加亲核试剂在预定速率下进行裂解。本文还披露了制备和使用这些材料的方法。
• Recognition of Ten Base Pairs of DNA by Head-to-Head Hairpin Dimers
  作者：Philipp Weyermann、Peter B. Dervan

  DOI：10.1021/ja020258k

  日期：2002.6.1

  Hairpin polyamides coupled head-to head with alkyl linkers of varying lengths were synthesized, and their DNA binding properties were determined. The DNA binding affinities of six-ring hairpin dimers Im-Im-Py-(R)[Im-Im-Py-(R)(HNCO(CH))(n)(CO)gamma-Py-Py-Py-beta-Dp](NH)gamma-Im-Py-Py-beta-Dp (1-4) (where n = 1-4) for their 10-bp, 11-bp, and 12-bp match sites 5'-TGGCATACCA-3', 5'-TGGCATTACCA-3', and

  合成了与不同长度的烷基接头头对头偶联的发夹聚酰胺，并测定了它们的 DNA 结合特性。六环发夹二聚体Im-Im-Py-(R)[Im-Im-Py-(R)(HNCO(CH))(n)(CO)γ-Py-Py-Py-β的DNA结合亲和力-Dp](NH)gamma-Im-Py-Py-beta-Dp (1-4)（其中 n = 1-4）用于它们的 10-bp、11-bp 和 12-bp 匹配位点 5'-TGGCATACCA -3'、5'-TGGCATTACCA-3' 和 5'-TGGCATATACCA-3' 由定量 DNase I 足迹滴定确定。最具选择性的二聚体 Im-Im-Py-(R)[Im-Im-Py-(R)(HNCO(CH)(2))(2)(CO)gamma-Py-Py-Py-beta-Dp] (NH)gamma-Im-Py-Py-beta-Dp (2) 结合 10-bp 位点匹配位点，平衡关联常数为
• Pegylated Ion Channel Modulating Compounds
  申请人：Cheu L.S. Elizabeth

  公开号：US20080021005A1

  公开（公告）日：2008-01-24

  This invention is directed to PEGlyated derivatives, drug conjugates and isotopic derivatives of certain ion channel modulating compounds. Pharmaceutical compositions and methods of use of also disclosed

  这项发明是针对某些离子通道调节化合物的PEG化衍生物、药物偶联物和同位素衍生物。还公开了制药组合物和使用方法。
• Methods Of Coupling Multidentate AZA Ligands To Targeting Molecules
  申请人：GIOVENZANA Giovanni Battista

  公开号：US20110082280A1

  公开（公告）日：2011-04-07

  Methods of coupling targeting molecules to multidentate aza ligands of general formula (I): in which: R 1 through R 5 and FG are as defined in the specification are presented. The aza ligands and/or the resulting conjugates may be labeled with bi-trivalent ions of the metal elements having atomic number ranging between 20 and 31, 39, 42, 43, 44, 49, and between 57 and 83, and radioisotopes chosen among 203 Pb, 67 Ga, 68 Ga, 72 As, 111 In, 113 In, 90 Y, 97 Ru, 62 Cu, 64 Cu, 52 Fe, 52m Mn, 140 La, 175 Yb, 153 Sm, 166 Ho, 149 Pm, 177 Lu, 142 Pr, 159 Gd, 212 Bi, 47 Sc, 149 Pm, 67 Cu, 111 Ag, 199 Au, 161 Tb, 51 Cr, 167 Tm, 141 Ce, 168 Yb, 88 Y, 165 Dy, 166 Dy, 97 Ru, 103 Ru, 186 Re, 188 Re, 99m Tc, 211 Bi, 212 Bi, 213 Bi, 214 Bi, 105 Rh, 109 Pd, 117m Sn, 177 Sn and 199 Au.

  介绍了将靶向分子耦合到一般式（I）中多配位氮杂环配体的方法，其中：R1到R5和FG如说明书中所定义。该氮杂环配体和/或所得到的共轭物可以用原子序数在20到31、39、42、43、44、49之间以及在57到83之间的金属元素的双价或三价离子标记，并且可以选择放射性同位素，包括203Pb、67Ga、68Ga、72As、111In、113In、90Y、97Ru、62Cu、64Cu、52Fe、52mMn、140La、175Yb、153Sm、166Ho、149Pm、177Lu、142Pr、159Gd、212Bi、47Sc、149Pm、67Cu、111Ag、199Au、161Tb、51Cr、167Tm、141Ce、168Yb、88Y、165Dy、166Dy、97Ru、103Ru、186Re、188Re、99mTc、211Bi、212Bi、213Bi、214Bi、105Rh、109Pd、117mSn、177Sn和199Au。