gamma-苄基谷氨酸-丙氨酸共聚物 | 37475-30-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: gamma-苄基谷氨酸-丙氨酸共聚物
• 英文名称: (2S)-2-amino-5-oxo-5-phenylmethoxypentanoic acid;(2S)-2-aminopropanoic acid
• CAS: 37475-30-2
• 化学式: C15H22N2O6
• 分子量: 326.34
• InChiKey: LUBYMBWOEXNKPF-GBZGCGEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.34
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  153
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• Enhanced melanoma cancer prevention by novel melanotropins
  申请人：ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA

  公开号：US10188704B2

  公开（公告）日：2019-01-29

  A gamma-melanocyte stimulating hormone (γ-MSH) derivative having improved stability, selectivity and bioavailabilty. The γ-MSH derivative is selective for the melanocortin-1 receptor (MC1 R) and is deliverable to skin cells via topical or transdermal delivery. The γ-MSH derivative is made up of naturally occurring amino acids for stimulating melanin from within for photoprotection of human skin against ultraviolet radiation damage.

  一种γ-黑素细胞刺激素（γ-MSH）衍生物，具有更好的稳定性、选择性和生物利用度。γ-MSH衍生物对黑色素皮质素-1受体（MC1 R）具有选择性，可通过局部给药或透皮给药进入皮肤细胞。γ-MSH衍生物由天然氨基酸组成，可从内部刺激黑色素，保护人体皮肤免受紫外线辐射的伤害。
• Melanocortin 1 receptor ligands and methods of use
  申请人：H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

  公开号：US10329326B2

  公开（公告）日：2019-06-25

  The subject invention pertains to a modified MC1R peptide ligand comprising a peptide that is a melanocortin 1 receptor (MC1R) ligand and a functionality or linker, such as a click functionality, for conjugation to a surface or agent. The modified MC1R peptide ligand can be coupled, e.g., via a click reaction with a complementary click functionality attached, to a moiety to form an MC1R-targeted agent. Drugs, contrast agents, polymers, particles, micelles, surfaces of larger structures, or other moieties can be targeted to the MC1R. The subject invention also pertains to a MC1R peptide ligand-micelle complex comprising a peptide that is a melanocortin 1 receptor ligand connected via a click reaction product to a micelle. The micelle is stable in vivo and can target melanoma tumor cells by association of the peptide ligand with the MC1R or the tumor and selectively provide a detectable and/or therapeutic agent (such as an imageable contrast agent and/or anti-cancer agent) selectively to the tumor cell.

  本发明涉及一种修饰的 MC1R 多肽配体，该配体包括一种黑色素皮质素 1 受体（MC1R）配体多肽和一种用于与表面或制剂共轭的官能团或连接体，例如点击官能团。经修饰的 MC1R 肽配体可通过附带互补点击官能团的点击反应等方式与分子偶联，形成 MC1R 靶向制剂。药物、造影剂、聚合物、颗粒、胶束、较大结构的表面或其他分子都可以靶向 MC1R。本发明还涉及一种 MC1R 肽配体-胶束复合物，该复合物包括通过点击反应产物与胶束连接的黑色素皮质素 1 受体配体肽。该胶束在体内稳定，可通过多肽配体与 MC1R 或肿瘤的结合靶向黑色素瘤肿瘤细胞，并选择性地向肿瘤细胞提供可检测和/或治疗剂（如可成像的造影剂和/或抗癌剂）。
• ENHANCED MELANOMA CANCER PREVENTION BY NOVEL MELANOTROPINS
  申请人：The Arizona Board of Regents On Behalf of the University of Arizona

  公开号：EP3297655A1

  公开（公告）日：2018-03-28
• MELANOCORTIN 1 RECEPTOR LIGANDS AND METHODS OF USE
  申请人：Gillies Robert J.

  公开号：US20140112873A1

  公开（公告）日：2014-04-24

  The subject invention pertains to a modified MC1R peptide ligand comprising a peptide that is a melanocortin 1 receptor (MC1R) ligand and a functionality or linker, such as a click functionality, for conjugation to a surface or agent. The modified MC1R peptide ligand can be coupled, e.g., via a click reaction with a complementary click functionality attached, to a moiety to form an MC1R-targeted agent. Drugs, contrast agents, polymers, particles, micelles, surfaces of larger structures, or other moieties can be targeted to the MC1R. The subject invention also pertains to a MC1R peptide ligand-micelle complex comprising a peptide that is a melanocortin 1 receptor ligand connected via a click reaction product to a micelle. The micelle is stable in vivo and can target melanoma tumor cells by association of the peptide ligand with the MC1R or the tumor and selectively provide a detectable and/or therapeutic agent (such as an imageable contrast agent and/or anti-cancer agent) selectively to the tumor cell.
• MELANOTROPIN LIGANDS FOR SKIN CARE
  申请人：THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA

  公开号：US20150284431A1

  公开（公告）日：2015-10-08

  A MC1R peptide ligand-elastic vesicle complex for preventing skin maladies. The MC1R peptide ligand is modified by coupling the melanocortin 1 receptor (MC1R) ligand to a functionality or linker, such as a click functionality, for conjugation to a surface or agent. The modified MC1R peptide ligand can be coupled, e.g., via a click reaction with a complementary click functionality attached, to a moiety to form an MC1R-targeted agent. Drugs, contrast agents, polymers, particles, micelles, elastic vesicles, surfaces of larger structures, or other moieties can be targeted to the MC1R. The MC1R peptide ligand-elastic vesicle complex is prepared as a patch or viscous emulsion that can be applied to human skin.