3-(2-(dipropylamino)ethyl)-1H-indol-4-ol | 63065-88-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-(2-(dipropylamino)ethyl)-1H-indol-4-ol
• 英文别名: Dipropyl-4-hydroxytryptamine；3-[2-(dipropylamino)ethyl]-1H-indol-4-ol
• CAS: 63065-88-3
• 化学式: C₁₆H₂₄N₂O
• 分子量: 260.379
• InChiKey: MZLRMPTVOVJXLW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  39.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(2-(dipropylamino)ethyl)-1H-indol-4-ol 在 盐酸 作用下， 以 乙醇 、 二氯甲烷 、 水 为溶剂， 反应 0.5h， 以73%的产率得到4-hydroxy-N,N-di-n-propyl-tryptammonium chloride
  参考文献：
  名称：

  [EN] CRYSTALLINE 4-HYDROXY-N,N-DI-N-PROPYLTRYPTAMMONIUM (4-HO-DPT) SALTS
  [FR] SELS CRISTALLINS DE 4-HYDROXY-N, N-DI-N-PROPYLTRYPTAMMONIUM (4-HO-DPT)

  摘要：

  This disclosure relates to crystalline bis(4-hydroxy-N,N-di-n-propyltryptammonium)fumarate tetrahydrate (4-HO-DPT fumarate-4H2O) and to crystalline 4-hydroxy-N,N-di-n-propyl-tryptammonium chloride (4-HO-DPT chloride). Compositions containing crystalline 4-HO-DPT fumarate-4H2O or crystalline 4-HO-DPT chloride, and methods of use are disclosed.

  公开号：

  WO2021236759A2

文献信息

• [EN] COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS<br/>[FR] FORMULATIONS SALINES DE COMPOSÉS PHARMACEUTIQUES À BASE D'AGENTS COMPLEXANTS
  申请人：BEXSON BIOMEDICAL INC

  公开号：WO2022109050A1

  公开（公告）日：2022-05-27

  Provided herein are pharmaceutical formulations and pharmaceutical compound salts which utilize complexing agents as counterions. Such formulations and salts are useful for treating a variety of disease and disorders.

  本文提供了药物制剂和药物化合物盐，其使用络合剂作为反离子。这些制剂和盐对治疗各种疾病和障碍有用。
• Methods of treating food allergy conditions
  申请人：Palo Alto Investors LP

  公开号：US11045454B2

  公开（公告）日：2021-06-29

  Methods for treating a subject for a food allergy condition are provided. Aspects of the methods include administering to a subject in need thereof a psychedelic agent in a manner effective to treat the subject for a food allergy condition. Effective administration of a psychedelic agent may include administering the psychedelic agent in an amount effective to treat the subject for the food allergy condition. In some instances, the subject is known to have a food allergy condition.

  本文提供了治疗食物过敏症的方法。这些方法的各个方面包括以有效治疗食物过敏症的方式向有需要的受试者施用迷幻剂。有效施用迷幻剂可包括以有效治疗受试者食物过敏症的量施用迷幻剂。在某些情况下，受试者已知患有食物过敏症。
• Complexing agent salt formulations of pharmaceutical compounds
  申请人：Bexson Biomedical, Inc.

  公开号：US11534454B2

  公开（公告）日：2022-12-27

  Provided herein are pharmaceutical formulations and pharmaceutical compound salts which utilize complexing agents as counterions. Such formulations and salts are useful for treating a variety of disease and disorders.

  本文提供了利用络合剂作为反离子的药物制剂和药物化合物盐。这些制剂和盐类可用于治疗各种疾病和失调。
• COMPOSITIONS COMPRISING A PSILOCYBIN DERIVATIVE AND A CANNABINOID
  申请人：CaaMTech, LLC

  公开号：US20190142851A1

  公开（公告）日：2019-05-16

  This disclosure pertains to new compositions and methods comprising a psilocybin derivative. In one embodiment, the compositions disclosed herein are used for a method of regulating a neurotransmitter receptor, e.g., a serotonin receptor. In one embodiment, the compositions disclosed herein comprise purified compounds, e.g., a purified psilocybin derivative, a purified cannabinoid, or purified terpene.
• Methods of Treating Food Allergy Conditions
  申请人：Palo Alto Investors LP

  公开号：US20200179349A1

  公开（公告）日：2020-06-11

  Methods for treating a subject for a food allergy condition are provided. Aspects of the methods include administering to a subject in need thereof a psychedelic agent in a manner effective to treat the subject for a food allergy condition. Effective administration of a psychedelic agent may include administering the psychedelic agent in an amount effective to treat the subject for the food allergy condition. In some instances, the subject is known to have a food allergy condition.