diisopropylphenyl amine | 153921-59-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: diisopropylphenyl amine
• 英文别名: di-isopropylaniline；2,3-Di(propan-2-yl)aniline
• CAS: 153921-59-6
• 化学式: C₁₂H₁₉N
• 分子量: 177.29
• InChiKey: QBCIVSJJZKMYEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] HYDROXYLATED TROPOLONE INHIBITORS OF NUCLEOTIDYL TRANSFERASES IN HERPESVIRUS AND HEPATITS B AND USES THEREFOR<br/>[FR] INHIBITEURS HYDROXYLÉS DE TROPOLONE DE NUCLÉOTIDYL-TRANSFÉRASES UTILISÉS DANS LE TRAITEMENT DU VIRUS DE L'HERPÈS ET DE L'HÉPATITE B ET LEURS UTILISATIONS
  申请人：UNIV SAINT LOUIS

  公开号：WO2016201243A1

  公开（公告）日：2016-12-15

  The present disclosure relates to inhibitors of herpesvirus nucleic acid metabolism and inhibitors of Hepatitis B virus. Also provided are methods of treatment using these agents.

  本公开涉及抑制疱疹病毒核酸代谢和乙型肝炎病毒的抑制剂。还提供了使用这些药剂的治疗方法。
• SALT AND PROCESS FOR PRODUCING ACID GENERATOR
  申请人：YOSHIDA Isao

  公开号：US20110201823A1

  公开（公告）日：2011-08-18

  A salt represented by the formula (I0): wherein Q 1 and Q 2 each independently represent a fluorine atom or a C1-C6 perfluoroalkyl group, L 1 represents a divalent C1-C17 hydrocarbon group in which one or more —CH 2 — can be replaced by —O— or —CO—, m represents 1 or 2, and Z m+ represents m-valent organic or inorganic cation.

  根据您提供的化学公式(I0)，其翻译成中文为： 其中Q1和Q2各自独立代表一个氟原子或一个C1-C6全氟烷基团，L1代表一个二价的C1-C17碳氢化合物基团，在该基团中，一个或多个—CH2—可以被—O—或—CO—所替换，m代表1或2，而Zm+代表m价有机或无机阳离子。
• [EN] TRANSITION METAL COMPOUNDS FOR OLEFIN POLYMERIZATION AND OLIGOMERIZATION<br/>[FR] COMPOSES METALLIQUES DE TRANSITION POUR LA POLYMERISATION D'OLEFINES ET L'OLIGOMERISATION
  申请人：EXXONMOBIL CHEM PATENTS INC

  公开号：WO2005118605A1

  公开（公告）日：2005-12-15

  This invention relates to new transition metal catalyst compounds represented by the formula (I): where: M and M' are, independently, a group 8, 9, 10 or 11 transition metal, preferably Ni, Co, Pd, Cu or Fe; each R group is, independently, is, hydrogen, or a hydrocarbyl, substituted hydrocarbyl, halocarbyl, substituted halocarbyl, silylcarbyl, substituted silylcarbyl, germylcarbyl, or substituted germylcarbyl substituents, and optionally, adjacent R groups may join together to form a substituted or unsubstituted, saturated, partially unsaturated, or aromatic cyclic or polycyclic substituent; R' is hydrogen, or a hydrocarbyl, substituted hydrocarbyl, halocarbyl, substituted halocarbyl, silylcarbyl, substituted silylcarbyl, germylcarbyl, or substituted germylcarbyl substituents, and optionally, adjacent R groups may join together with R' to form a substituted or unsubstituted, saturated, partially unsaturated, or aromatic cyclic or polycyclic substituent; each X group is, independently, is, hydrogen, a halogen, or a hydrocarbyl, substituted hydrocarbyl, halocarbyl, substituted halocarbyl, silylcarbyl, substituted sililcarbyl, germylcarbyl, or substituted germylcarbyl substituents, and optionally, adjacent X groups may join together to form a substituted or unsubstituted, saturated, partially unsaturated, or aromatic cyclic or polycyclic substituent; m and m’ are, independently, 0, 1, 2, or 3; z and z’ are, independently, 0, 1, 2, or 3; N is nitrogen; Q is hydrogen, or a hydrocarbyl, substituted hydrocarbyl, halocarbyl, substituted halocarbyl, silylcarbyl, substituted silylcarbyl, germylcarbyl, or substituted germylcarbyl substituents; Q’ is hydrogen, or a hydrocarbyl, substituted hydrocarbyl, halocarbyl, substituted halocarbyl, silylcarbyl, substituted silylcarbyl, germylcarbyl or substituted germylcarbyl substituents; and L is a hydrocarbyl, substituted hydrocarbyl, halocarbyl, substituted halocarbyl, silylcarbyl, substituted silylcarbyl, germylcarbyl, or substituted germylcarbyl substituent.

  这项发明涉及由式(I)表示的新过渡金属催化剂化合物，其中：M和M'分别是8、9、10或11族过渡金属，优选为Ni、Co、Pd、Cu或Fe；每个R基分别是氢，或烃基，取代烃基，卤代烃基，取代卤代烃基，硅烃基，取代硅烃基，锗烃基，或取代锗烃基取代基，且可选地，相邻的R基可以结合在一起形成取代或未取代的饱和、部分不饱和或芳香环或多环取代基；R'是氢，或烃基，取代烃基，卤代烃基，取代卤代烃基，硅烃基，取代硅烃基，锗烃基，或取代锗烃基取代基，且可选地，相邻的R基可以与R'结合在一起形成取代或未取代的饱和、部分不饱和或芳香环或多环取代基；每个X基分别是氢，卤素，或烃基，取代烃基，卤代烃基，取代卤代烃基，硅烃基，取代硅烃基，锗烃基，或取代锗烃基取代基，且可选地，相邻的X基可以结合在一起形成取代或未取代的饱和、部分不饱和或芳香环或多环取代基；m和m'分别为0、1、2或3；z和z'分别为0、1、2或3；N为氮；Q为氢，或烃基，取代烃基，卤代烃基，取代卤代烃基，硅烃基，取代硅烃基，锗烃基，或取代锗烃基取代基；Q'为氢，或烃基，取代烃基，卤代烃基，取代卤代烃基，硅烃基，取代硅烃基，锗烃基，或取代锗烃基取代基；L为烃基，取代烃基，卤代烃基，取代卤代烃基，硅烃基，取代硅烃基，锗烃基，或取代锗烃基取代基。
• Perfluoroalkylated aniline compound and process for producing the same
  申请人：——

  公开号：US20020198399A1

  公开（公告）日：2002-12-26

  The present invention provides an aniline derivative represented by the formula (I) 1 wherein R 1 and R 2 are each H, (C 1-12 )alkyl, (C 3-8 )cycloalkyl, hydroxy(C 1-12 )alkyl, hydroxycarbonyl (C 1-12 )alkyl, (C 1-6 )-alkoxycarbonyl(C 1-6 )alkyl, —COR 8 , wherein R 8 is H, halo-(C 1-12 )alkyl, (C 3-8 )cycloalkyl or (substituted) phenyl, COOR 9 , wherein R 9 is a halo(C 1-6 )alkyl group, (substituted) phenyl or (substituted) benzyl; R 3 , R 4 , R 5 , R 6 and R 7 are each H, halogen, OH, nitro, halo(C 1-12 )alkylthio, (substituted)amino-(C 1-2 )alkyl, (substituted) phenyl, (substituted) benzyl, amino, —N(R 10 )R 11 wherein R 10 and R 11 are each H, alkyl, cycloalkyl, (substituted) phenyl, (substituted) benzyl, —COR 8 or COOR 9 , or (C 2-27 )perfluoroalkyl, etc., and a process for producing the aniline derivative. According to the process of the present invention, perfluoroalkylaniline derivatives can be obtained by using various anilines as the substrate with a high position selectivity and high yield.

  本发明提供了一种由公式(I)表示的苯胺衍生物： 1 其中R 1 和R 2 各自是H，(C 1-12 )烷基，(C 3-8 )环烷基，羟基(C 1-12 )烷基，羟甲氧基(C 1-12 )烷基，(C 1-6 )-烷氧甲氧基(C 1-6 )烷基，—COR 8 ，其中R 8 是H，卤代-(C 1-12 )烷基，(C 3-8 )环烷基或(取代)苯基，COOR 9 ，其中R 9 是卤代(C 1-6 )烷基，(取代)苯基或(取代)苄基；R 3 ，R 4 ，R 5 ，R 6 和R 7 各自是H，卤素，OH，硝基，卤代-(C 1-12 )烷基硫，(取代)氨基-(C 1-2 )烷基，(取代)苯基，(取代)苄基，氨基，—N(R 10 )R 11 ，其中R 10 和R 11 各自是H，烷基，环烷基，(取代)苯基，(取代)苄基，—COR 8 或COOR 9 ，或(C 2-27 )全氟烷基等，以及一种用于生产该苯胺衍生物的过程。根据本发明的过程，可以通过使用各种苯胺作为底物，以高位置选择性和高收率获得全氟烷基苯胺衍生物。
• [EN] INHIBITORS OF CYSTATHIONINE BETA SYNTHASE TO REDUCE THE NEUROTOXIC OVERPRODUCTION OF ENDOGENOUS HYDROGEN SULFIDE<br/>[FR] INHIBITEURS DE LA CYSTATHIONINE BÊTA SYNTHASE UTILISABLES EN VUE DE LA RÉDUCTION DE LA SURPRODUCTION NEUROTOXIQUE DE SULFURE D'HYDROGÈNE ENDOGÈNE
  申请人：FOND JEROME LEJEUNE

  公开号：WO2013068592A1

  公开（公告）日：2013-05-16

  The invention is directed to inhibitors of cystathionine beta synthase which, among other biochemical effects, allow reduction of the neurotoxic overproduction of endogenous hydrogen sulphide. These compounds and pharmaceutical compositions containing them are useful for the prevention and treatment of cognitive disorders such as cognitive disorders in Down syndrome. The invention also relates to methods for preventing or treating cognitive disorders including cognitive disorders in Down Syndrome.

  本发明涉及胱硫醚β合酶抑制剂，除其他生化作用外，还允许减少内源性硫化氢的神经毒性过度产生。这些化合物以及含有它们的药物组合物对于预防治疗认知障碍，如下氏综合症中的认知障碍等是有用的。本发明还涉及用于预防或治疗认知障碍的方法，包括下氏综合症中的认知障碍。