9-oxonon-1-yl 4-methylbenzenesulfonate | 1146096-89-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 9-oxonon-1-yl 4-methylbenzenesulfonate
• 英文别名: 9-Oxononyl 4-methylbenzenesulfonate
• CAS: 1146096-89-0
• 化学式: C₁₆H₂₄O₄S
• 分子量: 312.43
• InChiKey: NGLMSXQPCHRUHO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  21
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  68.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  9-oxonon-1-yl 4-methylbenzenesulfonate 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 5.0h， 生成 (Z)-2-((9-((tert-butyldimethylsilyl)oxy)non-8-en-1-yl)oxy)isoindoline-1,3-dione
  参考文献：
  名称：

  Strategies to Control Alkoxy Radical-Initiated Relay Cyclizations for the Synthesis of Oxygenated Tetrahydrofuran Motifs

  摘要：

  Radical relay cyclizations initiated by alkoxy radicals are a powerful tool for the rapid construction of substituted tetrahydrofurans. The scope of these relay cyclizations has been dramatically increased with the development of two strategies that utilize an oxygen atom in the substrate to accelerate the desired hydrogen atom transfer (HAT) over competing pathways. This has enabled a chemoselective 1,6-HAT over a competing 1,5-HAT. Furthermore, this allows for a chemoselective 1,5-HAT over competing direct cyclizations and beta-fragmentations. Oxygen atom incorporation leads to a general increase in cyclization diastereoselectivity over carbon analogues. This chemoselective relay cyclization strategy was utilized in the improved synthesis of the tetrahydrofuran fragment in (-)-amphidinolide K.

  DOI：

  10.1021/jo502499a
• 作为产物：
  描述：

  9-hydroxynonyl 4-methylbenzenesulfonate 在 草酰氯 、 二甲基亚砜 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.5h， 以71%的产率得到9-oxonon-1-yl 4-methylbenzenesulfonate
  参考文献：
  名称：

  利用烷氧基自由基引发的自由基中继环化反应构建碳杂环和杂环

  摘要：

  利用烷氧基自由基引发的自由基中继环化，已经开发出一种快速构建碳环和杂环的有效方法。线性底物被环化以优异的收率形成各种环戊烷，吡咯烷，四氢吡喃和四氢呋喃衍生物。该方法被用作合成（-）-两性内酯K中四氢呋喃片段的关键步骤。

  DOI：

  10.1021/ol900481e

文献信息

• Process for preparing functional group-containing olefinic compounds
  申请人：3M Innovative Properties Company

  公开号：EP2314559A2

  公开（公告）日：2011-04-27

  A process for preparing functional group-containing olefinic compounds comprising the steps of (a) reacting (1) at least one functional group-containing nucleophile with (2) at least one carbonyl-containing compound that comprises at least one group that is a leaving group, or that is capable of subsequent conversion to a leaving group, and that optionally comprises one or more isolated carbon to carbon double or triple bonds, to form the corresponding functional group-containing carbonyl-containing compound, said carbonyl-containing compound being selected from the group consisting of ketones and aldehydes; and (b) reacting said functional group-containing carbonyl-containing compound with at least one alkylidene phosphorane comprising an alkylidene moiety and three other moieties bonded to its phosphorus atom, said alkylidene moiety optionally comprising one or more carbon to carbon double or triple bonds, to form a functional group-containing olefinic compound.

  一种制备含官能团烯烃化合物的工艺，包括以下步骤 (a) 使(1)至少一种含官能团的亲核体与(2)至少一种含羰基的化合物反应，该化合物包含至少一个离去基团或可随后转化为离去基团的基团，并可选择包含一个或多个孤立的碳对碳双键或三键，以形成相应的含官能团的含羰基的化合物，所述含羰基的化合物选自由酮和醛组成的组；(b) 使所述含官能团的羰基化合物与至少一种亚烷基磷烷反应，所述亚烷基磷烷包括一个亚烷基分子和与磷原子成键的另外三个分子，所述亚烷基分子可选择包括一个或多个碳对碳双键或三键，以形成含官能团的烯烃化合物。
• PROCESS FOR PREPARING FUNCTIONAL GROUP-CONTAINING OLEFINIC COMPOUNDS
  申请人：3M Innovative Properties Company

  公开号：EP1678115A2

  公开（公告）日：2006-07-12
• Prosthetic Valve with Sealing Members and Methods of Use Thereof
  申请人：Tabor Charles

  公开号：US20110264206A1

  公开（公告）日：2011-10-27

  Embodiments of the present invention provide prosthetic valves having sealing members on the external surface thereof. The prosthetic heart valves of the present invention are preferably delivered by catheter directly through the apex of the heart or by other close range transcatheter delivery methods. Because these methods of implantation require a shorter length of catheter, a prosthetic valve can be more accurately oriented in the desired implantation location. Fluoroscopy can be used to further assist in orientation of the valve. The sealing members of the present invention can be positioned on the prosthetic valve such that, when the prosthetic valve is implanted in a native annulus, each provided sealing member is located adjacent to a commissural point of the native valve leaflets. Because the sealing members are precisely oriented on the prosthetic valve, a physician can ensure that the sealing members are aligned with the commissural points of the native valve leaflets. In embodiments of the present invention, the prosthetic valve can have a waisted middle section, and the sealing members can be located in the waisted middle section such that the crimped diameter of the prosthetic valve is not negatively impacted by the sealing members.
• US6838576B1
  申请人：——

  公开号：US6838576B1

  公开（公告）日：2005-01-04
• [EN] PROCESS FOR PREPARING FUNCTIONAL GROUP-CONTAINING OLEFINIC COMPOUNDS<br/>[FR] PROCEDE DE PREPARATION DE COMPOSES OLEFINIQUES CONTENANT UN GROUPE FONCTIONNEL
  申请人：3M INNOVATIVE PROPERTIES CO

  公开号：WO2005042462A2

  公开（公告）日：2005-05-12

  A process for preparing functional group-containing olefinic compounds comprises the steps of (a) reacting at least one alkylidene phosphorane with at least one carbonyl-containing compound that comprises at least one group that is a leaving group, or that is capable of subsequent conversion to a leaving group, to form an olefinic compound that comprises at least one leaving group, the carbonyl-containing compound being selected from the group consisting of ketones and aldehydes; and (b) reacting the olefinic compound with at least one functional group-containing nucleophile to form a functional group-containing olefinic compound.