[(3aS,8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-yl] N-methylcarbamate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: [(3aS,8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-yl] N-methylcarbamate
• 化学式: C₁₅H₂₁N₃O₂
• 分子量: 275.35
• InChiKey: PIJVFDBKTWXHHD-ZFWWWQNUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  44.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• N-Aminocarbamates related to physostigmine, a process for their preparation and their use as medicaments
  申请人：HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED

  公开号：EP0420140A2

  公开（公告）日：1991-04-03

  The present invention relates to compounds of the formula I, where X is hydrogen, halogen or loweralkyl; and R₁, R₂ and R₃ are each independently hydrogen, loweralkyl, cycloalkyl, arylloweralkyl or aryl, or alternatively the group -NR₂R₃ taken as a whole constitutes R₄ being hydrogen or loweralkyl and a process for their preparation. The compounds of the invention show central cholinergic innervative properties for treating various memory dysfunctions and can, therefore, be used as medicaments.

  本发明涉及式 I 的化合物、 其中 X 是氢、卤素或低级烷基；R₁、R₂ 和 R₃ 各自独立地是氢、低级烷基、环烷基、芳低级烷基或芳基，或作为一个整体的基团 -NR₂R₃ 构成。 R₄为氢或低级烷基的化合物及其制备方法。本发明的化合物具有治疗各种记忆功能障碍的中枢胆碱能抑制特性，因此可用作药物。
• 4- and 6-Carbamates related to physostigmine, a process and intermediates for their preparation and their use as medicaments
  申请人：HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED

  公开号：EP0484573B1

  公开（公告）日：1996-03-13