N-(2-aminooxy-ethyl)-methanesulfonamide | 848852-57-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: N-(2-aminooxy-ethyl)-methanesulfonamide
• 英文别名: N-(2-aminooxyethyl)methanesulfonamide
• CAS: 848852-57-3
• 化学式: C₃H₁₀N₂O₃S
• 分子量: 154.19
• InChiKey: AVXXAVLWFWIJIK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  89.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-(2-aminooxy-ethyl)-methanesulfonamide 、 4-(6-amino-5-formyl-pyrimidin-4-yl)-piperazine-1-carboxylic acid (4-isopropoxy-phenyl)-amide 以 甲醇 为溶剂， 生成 4-(6-amino-5-[(2-methanesulfonylamino-ethoxyimino)-methyl]-pyrimidin-4-yl)-piperazine-1-carboxylic acid (4-isopropoxy-phenyl)amide
  参考文献：
  名称：

  4-Amino-6-piperazin-1-yl-pyrimidine-5-carbaldehyde oximes as potent FLT-3 inhibitors

  摘要：

  A series of 4-amino-6-piperazin- I -yl-pyrimi dine- 5-carbaldehyde oximes has been discovered and developed as potent FLT3 tyrosine kinase inhibitors. The series exhibited potent antiproliferative activity against both an FLT3 ITD-mutated human leukemic cell line as well as a wild-type FLT3 BaF3 expressed cell line. The structure-activity relationship of this class of compounds is described. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.06.046
• 作为产物：
  描述：

  N-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yloxy)-ethyl]-methanesulfonamide 在 甲基肼 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以68%的产率得到N-(2-aminooxy-ethyl)-methanesulfonamide
  参考文献：
  名称：

  WO2008/24725

  摘要：

  公开号：

文献信息

• Aza-benzofuranyl compounds and methods of use
  申请人：Savy Pierre Pascal

  公开号：US20080085886A1

  公开（公告）日：2008-04-10

  The invention relates to azabenzofuranyl compounds of Formula I with anti-cancer and/or anti-inflammatory activity and more specifically to azabenzofuranyl compounds which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

  本发明涉及具有抗癌和/或抗炎活性的Formula I的氮杂苯并呋喃化合物，更具体地涉及抑制MEK激酶活性的氮杂苯并呋喃化合物。本发明提供了用于抑制异常细胞生长或治疗哺乳动物的增生性疾病或治疗炎症性疾病的组合物和方法。本发明还涉及使用该化合物进行哺乳动物细胞的体外、原位和体内诊断或治疗，或相关病理条件的方法。
• EP1674452
  申请人：——

  公开号：——

  公开（公告）日：——
• WO2008/24725
  申请人：——

  公开号：——

  公开（公告）日：——
• 4-Amino-6-piperazin-1-yl-pyrimidine-5-carbaldehyde oximes as potent FLT-3 inhibitors
  作者：Micheal D. Gaul、Guozhang Xu、Jennifer Kirkpatrick、Heidi Ott、Christian A. Baumann

  DOI：10.1016/j.bmcl.2007.06.046

  日期：2007.9

  A series of 4-amino-6-piperazin- I -yl-pyrimi dine- 5-carbaldehyde oximes has been discovered and developed as potent FLT3 tyrosine kinase inhibitors. The series exhibited potent antiproliferative activity against both an FLT3 ITD-mutated human leukemic cell line as well as a wild-type FLT3 BaF3 expressed cell line. The structure-activity relationship of this class of compounds is described. (C) 2007 Elsevier Ltd. All rights reserved.