{[(苄氧基)羰基]氨基}(环己基)乙酸 | 93025-71-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: {[(苄氧基)羰基]氨基}(环己基)乙酸
• 中文别名: A-[[(苯基甲氧基)羰基]氨基]-环己基乙酸
• 英文名称: N-(benzyloxycarbonyl)cyclohexylglycine
• 英文别名: DL-α-Benzyloxycarbonylamino-cyclohexyl-essigsaeure；2-(((Benzyloxy)carbonyl)amino)-2-cyclohexylacetic acid；2-cyclohexyl-2-(phenylmethoxycarbonylamino)acetic acid
• CAS: 93025-71-9
• 化学式: C₁₆H₂₁NO₄
• 分子量: 291.347
• InChiKey: CUSYTUPJAYLNFQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2924299090

反应信息

• 作为反应物：
  描述：

  甲醇 、 {[(苄氧基)羰基]氨基}(环己基)乙酸 在 Amberlyst A-15 作用下， 以97%的产率得到Methyl 2-cyclohexyl-2-(phenylmethoxycarbonylamino)acetate
  参考文献：
  名称：

  Base assisted substitution of α-amidoalkyl sulfones by nitromethane anion. A new entry to functionalized α-amino acids

  摘要：

  The nitromethane anion reacts with alpha-amidoalkyl sulfones in THF affording the corresponding nitro derivatives that upon oxidation with alkaline potassium permanganate give the corresponding N-protected a-amino acids. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00770-4
• 作为产物：
  描述：

  苄基(1-环己基-2-硝基乙基)氨基甲酸酯 在 potassium permanganate 作用下， 以 四氢呋喃 为溶剂， 以88%的产率得到{[(苄氧基)羰基]氨基}(环己基)乙酸
  参考文献：
  名称：

  Base assisted substitution of α-amidoalkyl sulfones by nitromethane anion. A new entry to functionalized α-amino acids

  摘要：

  The nitromethane anion reacts with alpha-amidoalkyl sulfones in THF affording the corresponding nitro derivatives that upon oxidation with alkaline potassium permanganate give the corresponding N-protected a-amino acids. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00770-4

文献信息

• [EN] BIVALENT ANTAGONISTS OF INHIBITORS OF APOPTOSIS PROTEINS<br/>[FR] ANTAGONISTES BIVALENTS D'INHIBITEURS DE PROTÉINES D'APOPTOSE
  申请人：HEPAGENE THERAPEUTICS HK LTD

  公开号：WO2020206000A1

  公开（公告）日：2020-10-08

  The present technology is directed to compounds, compositions, and methods related to treatment of cancers and viral infections mediated by IAPs, e.g., compounds of Formula I (including Formulas IA, IB, IC, ID, IE, IF, and IG), a stereoisomer thereof, or a pharmaceutically acceptable salt of the compound or the stereoisomer of the compound. In particular, the present compounds and compositions may be used to treat IAP-mediated ovarian cancer and hepatitis B infection.

  目前的技术是针对由IAP介导的癌症和病毒感染的化合物、组合物和治疗方法，例如Formula I（包括Formula IA、IB、IC、ID、IE、IF和IG）、其立体异构体，或该化合物或其立体异构体的药用盐。具体来说，目前的化合物和组合物可用于治疗IAP介导的卵巢癌和乙型肝炎感染。
• [EN] NOVEL 2-AMINO-QUINAZOLINE DERIVATIVES USEFUL AS INHIBITORS OF ß-SECRETASE (BACE)<br/>[FR] NOUVEAUX DERIVES DE 2-AMINO-QUINAZOLINE UTILES EN TANT QU'INHIBITEURS DE LA $G(B)-SECRETASE (BACE)
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2006017844A1

  公开（公告）日：2006-02-16

  The present invention is directed to novel 2-amino-3,4-dihydro-quinazoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer’s disease (AD) and related disorders. The compounds of the invention are inhibitors of β-secretase, also known as β-site cleaving enzyme and BACE.

  本发明涉及新颖的2-氨基-3,4-二氢喹唑啉衍生物，包含它们的药物组合物以及它们在治疗阿尔茨海默病（AD）和相关疾病中的用途。本发明的化合物是β-分泌酶的抑制剂，也被称为β-位点裂解酶和BACE。
• [EN] 2-AMINO-QUINAZOLINE DERIVATIVES USEFUL AS INHIBITORS OF B-SECRETASE (BACE)<br/>[FR] DERIVES DE 2-AMINO-QUINAZOLINE UTILES EN TANT QU'INHIBITEURS DE B-SECRETASE (BACE)
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2006024932A1

  公开（公告）日：2006-03-09

  The present invention is directed to novel 2-amino-3,4-dihydro­quinazoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of ß-secretase, also known as ß-site cleaving enzyme and BACE.

  本发明涉及新型2-氨基-3,4-二氢喹唑啉衍生物，包含它们的药物组合物以及其在治疗阿尔茨海默病（AD）和相关疾病中的用途。该发明的化合物是ß-分泌酶抑制剂，也称为ß-位点裂解酶和BACE。
• Novel 2-amino-quinazoline derivatives useful as inhibitors of beta-secretase (BACE)
  申请人：Bischoff Paul Francois

  公开号：US20060178383A1

  公开（公告）日：2006-08-10

  The present invention is directed to novel 2-amino-3,4-dihydro-quinazoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of β-secretase, also known as β-site cleaving enzyme and BACE.

  本发明涉及新型2-氨基-3,4-二氢喹唑啉衍生物、含有它们的制药组合物以及它们在治疗阿尔茨海默病（AD）和相关疾病中的应用。本发明的化合物是β-秘鲁酶的抑制剂，也称为β-位点裂解酶和BACE。
• Processes and intermediates
  申请人：Tanoury Gerald J.

  公开号：US20100174077A1

  公开（公告）日：2010-07-08

  The invention relates to compounds and processes useful for the preparation of protease inhibitors, particularly serine protease inhibitors. The protease inhibitors are useful for treatment of HCV infections.

  该发明涉及化合物和工艺，用于制备蛋白酶抑制剂，特别是丝氨酸蛋白酶抑制剂。这些蛋白酶抑制剂对治疗HCV感染有用。