(3S,4R,5R)-3-amino-4,5-dimethyl-octanoic acid | 849501-46-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (3S,4R,5R)-3-amino-4,5-dimethyl-octanoic acid
• 英文别名: (3S,4R,5R)-3-amino-4,5-dimethyloctanoic acid
• CAS: 849501-46-8
• 化学式: C₁₀H₂₁NO₂
• 分子量: 187.282
• InChiKey: HLISOYNJVMWYQM-HLTSFMKQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-(S)-[1-(R),2-(R)-dimethylpentyl]-2-[(S)-1-phenylethyl]-isoxazolidin-5-one 在 palladium on carbon 氢气 作用下， 以 乙醇 为溶剂， 反应 17.8h， 以86%的产率得到(3S,4R,5R)-3-amino-4,5-dimethyl-octanoic acid
  参考文献：
  名称：

  WO2008/4067

  摘要：

  公开号：

文献信息

• Amino acids with affinity for the alpha2delta-protein
  申请人：Deur James Christopher

  公开号：US20050124668A1

  公开（公告）日：2005-06-09

  Certain β-amino acids that bind to the alpha-2-delta (α2δ) subunit of a calcium channel are disclosed. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric, pain and other disorders.

  本文披露了一些能够与钙通道的α2δ亚基相结合的β-氨基酸。这些化合物及其药学上可接受的盐在治疗多种精神疾病、疼痛和其他疾病方面具有用途。
• AMINO ACIDS WITH AFFINITY FOR THE ALPHA2DELTA-PROTEIN
  申请人：Warner-Lambert Company LLC

  公开号：EP1667957A2

  公开（公告）日：2006-06-14
• PRODRUGS OF ALPHA-2-DELTA LIGANDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
  申请人：Gallop Mark A.

  公开号：US20110124705A1

  公开（公告）日：2011-05-26

  Prodrugs of alpha-2-delta ligands, pharmaceutical compositions of prodrugs of alpha-2-delta ligands, methods of making prodrugs of alpha-2-delta ligands, and methods of using prodrugs of alpha-2-delta ligands and pharmaceutical compositions of prodrugs of alpha-2-delta ligands to treat various diseases are disclosed.
• PRODRUGS OF GAMMA-AMINO ACID, ALPHA-2-DELTA LIGANDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
  申请人：Gallop Mark A.

  公开号：US20110130454A1

  公开（公告）日：2011-06-02

  Prodrugs of alpha-2-delta ligands, pharmaceutical compositions of prodrugs of alpha-2-delta ligands, methods of making prodrugs of alpha-2-delta ligands, and methods of using prodrugs of alpha-2-delta ligands and pharmaceutical compositions of prodrugs of alpha-2-delta ligands to treat various diseases are disclosed.
• [EN] AMINO ACIDS WITH AFFINITY FOR THE ALPHA2DELTA-PROTEIN<br/>[FR] ACIDES AMINES A AFFINITE POUR LA PROTEINE A2D
  申请人：WARNER LAMBERT CO

  公开号：WO2005030700A2

  公开（公告）日：2005-04-07

  Certain ß-amino acids that bind to the alpha-2-delta (a2S) subunit of a calcium channel are disclosed. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric, pain and other disorders.