2-[4-(6-methyl-2-oxo-2H-chromen-4-ylmethoxy)phenyl]-3-p-tolyl-thiazolidin-4-one | 1095704-56-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 2-[4-(6-methyl-2-oxo-2H-chromen-4-ylmethoxy)phenyl]-3-p-tolyl-thiazolidin-4-one
• 英文别名: 2-[4-[(6-Methyl-2-oxochromen-4-yl)methoxy]phenyl]-3-(4-methylphenyl)-1,3-thiazolidin-4-one
• CAS: 1095704-56-5
• 化学式: C₂₇H₂₃NO₄S
• 分子量: 457.55
• InChiKey: AIZBALYDEJFMSX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  81.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  6-methyl-4-(4-(p-tolylimino-methyl)-phenoxymethyl)chromen-2-one 、 巯基乙酸 在 zinc(II) chloride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 8.0h， 以59%的产率得到2-[4-(6-methyl-2-oxo-2H-chromen-4-ylmethoxy)phenyl]-3-p-tolyl-thiazolidin-4-one
  参考文献：
  名称：

  Synthetic and Biological Studies on 4-Aryloxymethyl Coumarinyl Thiazolidinones

  摘要：

  A series of new thiazolidinonyl-4-aryloxymetlaylcoumarins (4a-h) have been synthesized from 4-Bromomethylcoumarins (1a-b) and 4-aryliminomethyl-phenols (2a-d). Structures of all the new compounds are elucidated by elemental analyses, IR, H-1 NMR, and mass spectral data. All these compounds have been subjected to in-vitro antimicrobial and in-vivo anti-inflammatory screening.

  DOI：

  10.1080/10426500701555801

文献信息

• Synthetic and Biological Studies on 4-Aryloxymethyl Coumarinyl Thiazolidinones
  作者：K. Shivashankar、Lokesh A. Shastri、Manohar V. Kulkarni、Vijaykumar P. Rasal、Sandur V. Rajendra

  DOI：10.1080/10426500701555801

  日期：2007.12.24

  A series of new thiazolidinonyl-4-aryloxymetlaylcoumarins (4a-h) have been synthesized from 4-Bromomethylcoumarins (1a-b) and 4-aryliminomethyl-phenols (2a-d). Structures of all the new compounds are elucidated by elemental analyses, IR, H-1 NMR, and mass spectral data. All these compounds have been subjected to in-vitro antimicrobial and in-vivo anti-inflammatory screening.