3(Z)-3-hydroxyimino-6α-methyl-16α,17α-cyclohexanopregn-4-en-20-one | 1122705-59-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3(Z)-3-hydroxyimino-6α-methyl-16α,17α-cyclohexanopregn-4-en-20-one
• 英文别名: 1-[(2Z,4aR,4bS,6aS,6bS,10aR,11aS,11bR,13S)-2-hydroxyimino-4a,6a,13-trimethyl-4,4b,5,6,7,8,9,10,10a,11,11a,11b,12,13-tetradecahydro-3H-indeno[2,1-a]phenanthren-6b-yl]ethanone
• CAS: 1122705-59-2
• 化学式: C₂₆H₃₉NO₂
• 分子量: 397.601
• InChiKey: GLYUAOXOTOFLMY-NJMKFOBOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  29
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  49.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (6a,16b,17a)-17-乙酰基-6-甲基-16,24-环-21-去甲胆-4-烯-3-酮 在 吡啶 、 盐酸羟胺 作用下， 以 乙醇 为溶剂， 反应 24.0h， 以71%的产率得到3(E)-3-hydroxyimino-6α-methyl-16α,17α-cyclohexanopregn-4-en-20-one
  参考文献：
  名称：

  3- and 19-Oximes of 16α,17α-cyclohexanoprogesterone derivatives: Synthesis and interactions with progesterone receptor and other proteins

  摘要：

  Series of 3- and 19-oximes of 16 alpha,17 alpha-cyclohexanoprogesterone derivatives (pregna-D'-pentaranes) have been synthesized with the aim of probing the surfaces of progesterone receptor's and two other protein ligand binding pockets neighboring to 3- and 19-positions of steroid core. The same derivatives were also studied as possible intermediates for attachment to matrixes. The data on affinity constants suggest the presence of hydrophobic cavities with hydrophilic necks in the progesterone receptor and serum pentaranophylin near C19 of bound ligand and the lack of such a cavity in uterine pentaranophylin. Any of 3-oxime substitutions were found to significantly diminish the ligand affinity for the progesterone receptor. It was also found that some of these modifications, in the Z-configuration particularly, might increase the affinity for serum and uterine pentaranophylins. The latter finding suggests the presence of large cavities near C3 of bound ligand in these proteins and interchangeability between 3-keto and 3-oxime groups in ligand-protein interactions. (C) 2008 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.steroids.2008.03.003

文献信息

• 3- and 19-Oximes of 16α,17α-cyclohexanoprogesterone derivatives: Synthesis and interactions with progesterone receptor and other proteins
  作者：Inna S. Levina、Elena V. Pokrovskaya、Lidya E. Kulikova、Alexey V. Kamernitzky、Vadim V. Kachala、Alexander N. Smirnov

  DOI：10.1016/j.steroids.2008.03.003

  日期：2008.9

  Series of 3- and 19-oximes of 16 alpha,17 alpha-cyclohexanoprogesterone derivatives (pregna-D'-pentaranes) have been synthesized with the aim of probing the surfaces of progesterone receptor's and two other protein ligand binding pockets neighboring to 3- and 19-positions of steroid core. The same derivatives were also studied as possible intermediates for attachment to matrixes. The data on affinity constants suggest the presence of hydrophobic cavities with hydrophilic necks in the progesterone receptor and serum pentaranophylin near C19 of bound ligand and the lack of such a cavity in uterine pentaranophylin. Any of 3-oxime substitutions were found to significantly diminish the ligand affinity for the progesterone receptor. It was also found that some of these modifications, in the Z-configuration particularly, might increase the affinity for serum and uterine pentaranophylins. The latter finding suggests the presence of large cavities near C3 of bound ligand in these proteins and interchangeability between 3-keto and 3-oxime groups in ligand-protein interactions. (C) 2008 Elsevier Inc. All rights reserved.