3-ethyl-5-nitro-1H-indole-2-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-ethyl-5-nitro-1H-indole-2-carboxylate
• 化学式: C11H9N2O4-
• 分子量: 233.2
• InChiKey: OEEFADFZZDUNDL-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  102
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• CHEMICAL LINKERS AND CLEAVABLE SUBSTRATES AND CONJUGATES THEREOF
  申请人：Sufi Bilal

  公开号：US20100145036A1

  公开（公告）日：2010-06-10

  The present disclosure provides drug-ligand conjugates and drug-cleavable substrate conjugates that are potent cytotoxins. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.

  本公开提供了药物-配体共轭物和药物可切割底物共轭物，它们是有效的细胞毒素。该公开还涉及含有药物-配体共轭物的组合物，以及使用它们的治疗方法。
• CC-1065 analog synthesis
  申请人：IMMUNOGEN INC.

  公开号：US20030195365A1

  公开（公告）日：2003-10-16

  Improved synthesis of seco(−)CBI (5-hydroxy-3-amino-1-[S]-(chloromethyl)-1,2-dihydro-3H-benz(e)indole): 1 and improved syntheses therefrom of a wide variety of CC-1065 analogs that comprise a cyclopropabenzidole (CBI) alkylating moiety, and which are collectively DC1 and its derivatives, for the synthesis of cell-targeted therapeutic agents.

  改进的合成seco(−)CBI (5-羟基-3-氨基-1-［S］-（氯甲基）-1,2-二氢-3H-苯并[e]吲哚）：1和改进的从中合成广泛的CC-1065类似物，包括环丙基苯并吲哚（CBI）烷基化基团，它们共同构成DC1及其衍生物，用于合成针对细胞的治疗剂。
• CHEMICAL LINKERS WITH SINGLE AMINO ACIDS AND CONJUGATES THEREOF
  申请人：Chen Liang

  公开号：US20100113476A1

  公开（公告）日：2010-05-06

  The present disclosure provides drug-ligand conjugates that are potent cytotoxins and include a linker between the drug and ligand where the linker has a single amino acid. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.

  本公开提供了药物-配体结合物，其具有强效的细胞毒性，并在药物和配体之间包含一个仅有一个氨基酸的连接物。本公开还涉及包含药物-配体结合物的组合物以及使用它们的治疗方法。
• Conjugates of duocarmycin and anti-CD70 or anti-PSMA antibodies
  申请人：Medarex, Inc.

  公开号：EP2354163A2

  公开（公告）日：2011-08-10

  The present disclosure provides antibody-drug conjugates that are potent cytotoxins, wherein the drug is linked to the antibody through a linker. The disclosure is also directed to compositions containing the antibody-drug conjugates, and to methods of treatment using them.

  本公开提供了具有强效细胞毒素的抗体-药物共轭物，其中药物通过连接体与抗体连接。本公开还涉及含有抗体-药物共轭物的组合物以及使用它们进行治疗的方法。
• IMPROVED CC-1065 ANALOG SYNTHESIS
  申请人：Immunogen, Inc.

  公开号：EP1492766A1

  公开（公告）日：2005-01-05