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N-[2-(β-D-galactopyranosyloxy)ethyl]octadecanoylamide | 483362-39-6

中文名称
——
中文别名
——
英文名称
N-[2-(β-D-galactopyranosyloxy)ethyl]octadecanoylamide
英文别名
N-[2-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyethyl]octadecanamide
N-[2-(β-D-galactopyranosyloxy)ethyl]octadecanoylamide化学式
CAS
483362-39-6
化学式
C26H51NO7
mdl
——
分子量
489.693
InChiKey
HRTYFECXABFHQW-MMXJFWRNSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    5.7
  • 重原子数:
    34
  • 可旋转键数:
    21
  • 环数:
    1.0
  • sp3杂化的碳原子比例:
    0.96
  • 拓扑面积:
    129
  • 氢给体数:
    5
  • 氢受体数:
    7

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

点击查看最新优质反应信息

文献信息

  • Direct and Efficient Glycosylation Protocol for Synthesizing α-Glycolipids: Application to the Synthesis of KRN7000
    作者:Omar Boutureira、José Antonio Morales-Serna、Yolanda Díaz、M. Isabel Matheu、Sergio Castillón
    DOI:10.1002/ejoc.200701228
    日期:2008.4
    biologically active galactosyl ceramide KRN7000 and other α-glycolipids with excellent yield and stereoselectivity by using per-O-silylated galactosyl iodide and stannyl ethers as glycosylation partners. This direct glycosylation reaction reduces the overall number of steps and provides rapid access to biologically important α-galactosyl ceramide derivatives. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim
    在此,我们描述了一种简单实用的协议,用于通过使用过 O-甲硅烷基化半乳糖基碘和甲锡醚作为糖基化伙伴,以优异的产量和立体选择性获取生物活性半乳糖神经酰胺 KRN7000 和其他 α-糖脂。这种直接的糖基化反应减少了总步骤数,并提供了对生物学上重要的 α-半乳糖神经酰胺衍生物的快速获取。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
  • Novel galactosylceramide analogs, and beta-glucocerebrosidase activators, external skin preparations and method of activating beta-glucocerebrosidase using the analogs
    申请人:——
    公开号:US20040242499A1
    公开(公告)日:2004-12-02
    Galactosylceramide analogues represented by the following formula (1) or (2). 1 (wherein X and Y each represent S or O, R 1 and R 2 each represent an alkyl group or an alkenyl group each having 9 to 35 carbon atoms. R 3 represents an alkyl group or an alkenyl group each having 2 to 30 carbon atoms.) It is provided a &bgr;-glucocerebrosidase activator which is easily available, and external skin preparations and a method of activating &bgr;-glucocerebrosidase, in which improvement in formation of horny layer transmission barrier is expected by activating &bgr;-glucocerebrosidase so that an improved effect in rough skin is also expected.
    提供以下公式(1)或(2)所表示的类似半乳糖鞘氨醇: 其中,X和Y各代表S或O,R1和R2各代表一个有9到35个碳原子的烷基或烯基,R3代表一个有2到30个碳原子的烷基或烯基。提供了一种易于获取的β-葡糖鞘脂酶激活剂,以及激活β-葡糖鞘脂酶的外用皮肤制剂和方法,通过激活β-葡糖鞘脂酶,预期改善角质层传递屏障的形成,从而也预期改善皮肤粗糙的效果。
  • Novel galactosylceramide analogues, and beta-glucocerebrosidase activator, external skin preparations and method of activating beta-glucocerebrosidase using the same
    申请人:Uematsu Rie
    公开号:US20070111951A1
    公开(公告)日:2007-05-17
    Galactosylceramide analogues represented by the following formula (1) or (2). (wherein X and Y each represent S or O, R 1 and R 2 each represent an alkyl group or an alkenyl group each having 9 to 35 carbon atoms. R 3 represents an alkyl group or an alkenyl group each having 2 to 30 carbon atoms.) It is provided a β-glucocerebrosidase activator which is easily available, and external skin preparations and a method of activating β-glucocerebrosidase, in which improvement in formation of horny layer transmission barrier is expected by activating β-glucocerebrosidase so that an improved effect in rough skin is also expected.
  • US7183261B2
    申请人:——
    公开号:US7183261B2
    公开(公告)日:2007-02-27
  • NOVEL GALACTOSYLCERAMIDE ANALOGS AND BETA-GLUCOCEREBROSIDASE ACTIVATORS,EXTERNAL SKIN PREPARATIONS AND METHOD OF ACTIVATING BETA-GLUCOCEREBROSIDASE USING THE ANALOGS
    申请人:KAO CORPORATION
    公开号:EP1408045B1
    公开(公告)日:2009-05-27
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