γ-L-谷氨酰基-3-羧基-4-硝基苯胺 | 53602-84-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: γ-L-谷氨酰基-3-羧基-4-硝基苯胺
• 英文名称: (S)-5-[(4-Amino-4-carboxy-1-oxobutyl)amino]-2-nitrobenzoic acid
• 英文别名: 5-[[(4S)-4-amino-4-carboxybutanoyl]amino]-2-nitrobenzoic acid
• CAS: 53602-84-9
• 化学式: C12H13N3O7
• 分子量: 311.25
• InChiKey: AHFFWTMLFDZSOF-QMMMGPOBSA-N

物化性质

• 沸点：
  685.7±55.0 °C(Predicted)
• 密度：
  1.595±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.8
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  176
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• Method of measuring analyte using dry analytical element
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0524596A1

  公开（公告）日：1993-01-27

  A method of measuring an analyte using a dry analytical element which comprises,    a process of supplying a measuring reagent solution to the anlaytical element comprising at least a hydrophilic polymer layer and a microporous layer having a surface rendered hydrophilic and having a blood cell-separating ability laminated onto a water-impermeable support and not containing the measuring reagents to which a liquid sample has been supplied and thereby reaction occuring, and    a process of measuring the analytical element wherein the reaction occurred by an optical means. According the above method, the shelf life of the analytical element is greatly improved. Besides, since the measuring reagnts used in the conventional wet analysis can be used, it is not necessary to develop analytical elements for each measuring item. Moreover, one kind of analytical element can be applied to many items.

  一种使用干式分析元件测量分析物的方法，包括 向分析元件提供测量试剂溶液的过程，分析元件至少包括亲水聚合物层和微孔层，微孔层的表面亲水并具有血细胞分离能力，微孔层层压在不透水的支撑物上，且不包含已提供液体样品的测量试剂，从而发生反应，以及 测量分析元素的过程，其中反应是通过光学手段发生的。根据上述方法，分析元件的保存期限大大提高。此外，由于可以使用传统湿法分析中使用的测量试剂，因此没有必要为每个测量项目开发分析元件。而且，一种分析元件可适用于多种项目。
• Reagent for determining gamma-glutamyl transpeptidase
  申请人：EIKEN KAGAKU KABUSHIKI KAISHA

  公开号：EP0617131A1

  公开（公告）日：1994-09-28

  A reagent for determination of γ-GTP activity containing L-γ-glutamyl-3-carboxy-4-nitroanilide or a salt as a substrate and a transition metal ion or salt, a method for stabilizing L-γ-glutamyl-3-carboxy-4-nitroanilide using a transition metal ion salt, and a method for determining γ-GTP activity using this reagent. The transition metal ion or salt effectively prevents non-enzymatic decomposition (hydrolysis) of the substrate, thereby making it possible to supply the reagent as a solution.

  一种测定γ-GTP活性的试剂，含有作为底物的L-γ-谷氨酰-3-羧基-4-硝基苯胺或盐和过渡金属离子或盐，一种使用过渡金属离子盐稳定L-γ-谷氨酰-3-羧基-4-硝基苯胺的方法，以及一种使用该试剂测定γ-GTP活性的方法。过渡金属离子或盐可有效防止底物的非酶分解（水解），从而使该试剂以溶液形式供应成为可能。
• Absorption spectrometric analysis microchip
  申请人：USHIODENKI KABUSHIKI KAISHA

  公开号：EP1640703A2

  公开（公告）日：2006-03-29

  An absorption spectrometric analysis microchip with a chamber for holding a sample, a chamber for holding a reagent which reacts with this sample, a mixing chamber for mixing the reagent with the sample with the formation of a mixture and a sensing part with a sensing chamber for holding the mixture with a light incidence surface for the entry of light into the sensing chamber and a light exit surface for emergence of light from the sensing chamber. At least one of the light incidence surface and light exit surface is located in a recess area of the sensing part.

  一种吸收光谱分析微型芯片，具有一个用于容纳样品的腔室、一个用于容纳与该样品发生反应的试剂的腔室、一个用于将试剂与样品混合并形成混合物的混合腔室，以及一个具有用于容纳混合物的传感腔室的传感部件，该传感部件具有一个用于光进入传感腔室的光入射面和一个用于光从传感腔室射出的光出射面。光入射面和光出射面中至少有一个位于传感部件的凹槽内。
• METHOD OF JUDGING THE ONSET OF PERIODONTITIS
  申请人：Applied Cell Biotechnologies, Inc.

  公开号：EP1640721A1

  公开（公告）日：2006-03-29

  [Object] To provide a method to make a simple and clear distinction between gingivitis and periodontitis. [Solving Means] The inventor discovered that γ-GTP (γ-glutamyl transpeptidase) was scarcely contained in the gingival crevicular fluid of patients with gingivitis, but was contained in the gingival crevicular fluid of patients with periodontitis. Thus, the inventor provides a determination method of development of periodontitis by detecting or measuring γ-GTP contained in the gingival crevicular fluid. Also, this method can be applied to the determination of the development of peri-implant inflammation.

  目的 提供一种简单明了区分牙龈炎和牙周炎的方法。 [解决手段］ 本发明人发现，牙龈炎患者的牙龈缝隙液中几乎不含有γ-GTP（γ-谷氨酰转肽酶），但牙周炎患者的牙龈缝隙液中含有γ-GTP。因此，本发明人提供了一种通过检测或测量牙龈缝隙液中含有的 γ-GTP 来确定牙周炎发展情况的方法。此外，这种方法还可用于确定种植体周围炎症的发展情况。
• Absorption spectrum photometry microchip testing device and components thereof
  申请人：USHIODENKI KABUSHIKI KAISHA

  公开号：EP1659390A1

  公开（公告）日：2006-05-24

  A microchip testing device with a microchip having an absorbance measuring chamber for measuring absorbance, a transmitted light receiving unit for receiving light which has been emitted from a light source and has been transmitted through the absorbance measuring chamber, an aperture which extends in a straight line in the direction of the optical axis of the absorbance measuring chamber, with an entry opening for the light emitted by the light source on one end and a light exit opening on an opposite end from which the light enters the absorbance measuring chamber, an incident light beam splitter which is located in the optical path between the light exit opening of the aperture and the absorbance measuring chamber and which transmits part of the incident light and reflects another part of it, and a reflected light receiving part for receiving the light which has been reflected by the beam splitter.

  一种微型芯片测试装置，其微型芯片具有一个用于测量吸光度的吸光度测量室；一个用于接收从光源发射并通过吸光度测量室的透射光的透射光接收单元；一个沿吸光度测量室光轴方向直线延伸的孔、入射光分光镜，位于孔径的出光口和吸光度测量室之间的光路中，可透射部分入射光并反射另一部分入射光；以及反射光接收部件，用于接收经分光镜反射的光。