3-dipropylsulfamoyl-propionic acid | 388072-50-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: 3-dipropylsulfamoyl-propionic acid
• 英文别名: 3-(Dipropylsulfamoyl)propanoic acid
• CAS: 388072-50-2
• 化学式: C₉H₁₉NO₄S
• 分子量: 237.32
• InChiKey: PZQROWIVWDYHEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  15
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  83.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-dipropylsulfamoyl-propionic acid 在 盐酸 、 1-羟基苯并三唑 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 作用下， 以 1,4-二氧六环 为溶剂， 生成 N-[(1S,2R)-1-benzyl-2-hydroxy-3-(3-methoxy-benzylamino)-propyl]-3-dipropylsulfamoyl-propionamide
  参考文献：
  名称：

  Design of potent inhibitors of human β-secretase. Part 1

  摘要：

  We describe a novel series of potent inhibitors of human beta-secretase. These compounds possess the hydroxyethyl amine transition state isostere. A 2.5A crystal structure of inhibitor 32 bound to BACE is provided.

  DOI：

  10.1016/j.bmcl.2006.09.092
• 作为产物：
  描述：

  二正丙胺 在 sodium hydroxide 作用下， 以 乙醇 、 二氯甲烷 、 水 为溶剂， 生成 3-dipropylsulfamoyl-propionic acid
  参考文献：
  名称：

  Design of potent inhibitors of human β-secretase. Part 1

  摘要：

  We describe a novel series of potent inhibitors of human beta-secretase. These compounds possess the hydroxyethyl amine transition state isostere. A 2.5A crystal structure of inhibitor 32 bound to BACE is provided.

  DOI：

  10.1016/j.bmcl.2006.09.092

文献信息

• Substituted ureas and carbamates
  申请人：ELAN PHARMACEUTICALS, INC.

  公开号：US20040209925A1

  公开（公告）日：2004-10-21

  The invention provides compounds of formula I: 1 useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.

  本发明提供了公式I:1的化合物，用于治疗阿尔茨海默病和其他类似疾病。这些化合物包括β-分泌酶酶抑制剂，对于治疗阿尔茨海默病和其他在哺乳动物中表现为A beta肽沉积的疾病非常有用。本发明的化合物在制药组合物和治疗方法中非常有用，以减少A beta肽的形成。
• 1, 3, Diamino-2-Hydroxypropane Pro-Drug Derivatives
  申请人：Fobian Yvette M.

  公开号：US20080161325A1

  公开（公告）日：2008-07-03

  The present invention relates to compounds of formula (AA) (I) and (X): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.

  本发明涉及公式（AA）（I）和（X）的化合物，用于治疗阿尔茨海默病和其他类似疾病。这些化合物包括β-分泌酶酶的抑制剂，对治疗阿尔茨海默病和其他哺乳动物中A beta肽沉积的疾病具有用处。本发明的化合物适用于制备药物组合物和治疗方法，以减少A beta肽的形成。
• Substituted Ureas and Carbamates
  申请人：Pulley Shon R.

  公开号：US20080306136A1

  公开（公告）日：2008-12-11

  The invention provides compounds of formula I: useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.

  本发明提供了式I的化合物：用于治疗阿尔茨海默病和其他类似疾病。这些化合物包括β-分泌酶酶的抑制剂，对于治疗阿尔茨海默病和其他以A beta肽在哺乳动物中沉积为特征的疾病非常有用。本发明的化合物在制药组合物和治疗方法中用于减少A beta肽的形成。
• 1, 3-DIAMINO-2-HYDROXYPROPANE PRODRUG DERIVATIVES
  申请人：Elan Pharmaceuticals, Inc.

  公开号：EP1534693A2

  公开（公告）日：2005-06-01
• US7294642B2
  申请人：——

  公开号：US7294642B2

  公开（公告）日：2007-11-13