3-[4-(1,3,3-trimethyl-6-aza-bicyclo[3.2.1]octane-6-carbonyl)-indol-1-yl]-propionic acid | 1057653-91-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-[4-(1,3,3-trimethyl-6-aza-bicyclo[3.2.1]octane-6-carbonyl)-indol-1-yl]-propionic acid
• 英文别名: 3-[4-(1,3,3-trimethyl-6-azabicyclo[3.2.1]octane-6-carbonyl)indol-1-yl]propanoic acid
• CAS: 1057653-91-4
• 化学式: C₂₂H₂₈N₂O₃
• 分子量: 368.476
• InChiKey: KPOYQHLHPOJQAA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  62.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-[4-(1,3,3-trimethyl-6-aza-bicyclo[3.2.1]octane-6-carbonyl)-indol-1-yl]-propionic acid ethyl ester 在 sodium hydroxide 、 水 、 盐酸 作用下， 以 乙醇 、 水 为溶剂， 反应 2.0h， 以43%的产率得到3-[4-(1,3,3-trimethyl-6-aza-bicyclo[3.2.1]octane-6-carbonyl)-indol-1-yl]-propionic acid
  参考文献：
  名称：

  WO2008/110196

  摘要：

  公开号：

文献信息

• INDOLE- AND BENZIMIDAZOLE AMIDES AS HYDROXYSTEROID DEHYDROGENASE INHIBITORS
  申请人：Kilburn John Paul

  公开号：US20100076041A1

  公开（公告）日：2010-03-25

  The use of substituted amides of structure (I) for modulating the activity of 11 β-hydroxysteroid dehydrogenase type 1 (11 βHSD1) and the use of these compounds as pharmaceutical compositions, are described. Also a novel class of substituted amides, their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described. The present compounds are modulators and more specifically inhibitors of the activity of 11 βHSD1 and may be useful in the treatment, prevention and/or prophylaxis of a range of medical disorders where a decreased intracellular concentration of active glucocorticoid is desirable.

  本文描述了使用结构式(I)的取代酰胺来调节11β-羟基类固醇脱氢酶1型（11βHSD1）活性的方法，以及将这些化合物用作制药组合物。还描述了一种新型的取代酰胺类，其在治疗中的应用，包括制药组合物，以及其在制造药物方面的应用。这些化合物是11βHSD1活性的调节剂，更具体地是抑制剂，可用于治疗、预防和/或预防一系列医学疾病，其中降低细胞内活性糖皮质激素浓度是可取的。
• Indole- and benzimidazole amides as hydroxysteroid dehydrogenase inhibitors
  申请人：High Point Pharmaceuticals, LLC

  公开号：US08153798B2

  公开（公告）日：2012-04-10

  The use of substituted amides of structure (I) for modulating the activity of 11 β-hydroxysteroid dehydrogenase type 1 (11 βHSD1) and the use of these compounds as pharmaceutical compositions, are described. Also a novel class of substituted amides, their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described. The present compounds are modulators and more specifically inhibitors of the activity of 11 βHSD1 and may be useful in the treatment, prevention and/or prophylaxis of a range of medical disorders where a decreased intracellular concentration of active glucocorticoid is desirable.

  本文描述了使用结构式（I）的取代酰胺来调节11β-羟基类固醇脱氢酶类型1（11βHSD1）活性以及这些化合物作为药物组合物的用途。同时，还描述了一类新型的取代酰胺，它们在治疗中的用途、包含这些化合物的药物组合物，以及它们在制造药物中的用途。这些化合物是11βHSD1活性的调节剂，更具体地说是抑制剂，并且可能在需要降低活性糖皮质激素的细胞内浓度的一系列医学疾病的治疗、预防和/或预防中有用。
• US8153798B2
  申请人：——

  公开号：US8153798B2

  公开（公告）日：2012-04-10
• [EN] INDOLE- AND BENZIMIDAZOLE AMIDES AS HYDROXYSTEROID DEHYDROGENASE INHIBITORS<br/>[FR] INDOLE- ET BENZIMIDAZOLE AMIDES COMME INHIBITEURS DES HYDROXYSTÉROÏDE DÉSHYDROGÉNASES
  申请人：NOVO NORDISK AS

  公开号：WO2008110196A1

  公开（公告）日：2008-09-18

  [EN] The use of substituted amides of structure (I) for modulating the activity of 11 ß-hydroxysteroid dehydrogenase type 1 (11 ßHSD1) and the use of these compounds as pharmaceutical compositions, are described. Also a novel class of substituted amides, their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described. The present compounds are modulators and more specifically inhibitors of the activity of 11 ßHSD1 and may be useful in the treatment, prevention and/or prophylaxis of a range of medical disorders where a decreased intracellular concentration of active glucocorticoid is desirable.
  [FR] L'invention porte sur l'utilisation d'amides substitués de structure (I) pour moduler l'activité de la 11ß-hydroxystéroïde déshydrogénase de type 1 (11 ßHSD1) et sur l'utilisation de ces composés comme compositions pharmaceutiques. L'invention porte également sur une nouvelle classe d'amides substitués, sur leur utilisation en thérapie, sur des compositions pharmaceutiques comprenant les composés, ainsi que leur utilisation dans la fabrication de médicaments. Les présents composés sont des modulateurs et, plus spécifiquement, des inhibiteurs de l'activité de 11 ßHSD1 et peuvent être utiles dans le traitement, la prévention et/ou la prophylaxie d'une gamme de troubles médicaux où une concentration intracellulaire diminuée de glucocorticoïde actif et souhaitable.
• [EN] 11-ß-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (11B-HSD1) INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE LA 11-?-HYDROXYSTÉROÏDE DÉSHYDROGÉNASE DE TYPE 1 (11B-HSD1) ET LEURS UTILISATIONS
  申请人：ABBOTT LAB

  公开号：WO2011068927A2

  公开（公告）日：2011-06-09

  A method for treating a patient suffering from inflammation, chronic inflammation, pain, rheumatoid arthritis (RA), osteoarthritis and osteroporosis, comprising administering an effective amount of a selective inhibitor of the 11-β-hydroxysteroid dehydrogenase Type 1 enzyme.