DGCDH | 1028747-51-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: DGCDH
• 英文别名: 5-hydrazinyl-N-[2-[2-[(5-hydrazinyl-5-oxopentanoyl)amino]ethyldisulfanyl]ethyl]-5-oxopentanamide
• CAS: 1028747-51-4
• 化学式: C₁₄H₂₈N₆O₄S₂
• 分子量: 408.546
• InChiKey: GIGRVSOEPAAOQQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.9
• 重原子数：
  26
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  219
• 氢给体数：
  6
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  DGCDE 在 一水合肼 作用下， 以 乙醇 为溶剂， 以75%的产率得到DGCDH
  参考文献：
  名称：

  DIHYDRAZIDE COMPOUNDS, PREPARATION AND USES THEREOF

  摘要：

  揭示了具有化学式（I）或（II）的双肼化合物，其中R1-R4为烷基，取代烷基，芳基或聚醚基团。提供了制备这些双肼化合物的医用水凝胶和药物控释载体的用途。

  公开号：

  US20100048952A1

文献信息

• MULTIPLE MODIFIED DERIVATIVES OF GELATIN AND CROSSLINKED MATERIAL THEREOF
  申请人：Song Chan

  公开号：US20090306345A1

  公开（公告）日：2009-12-10

  The disclosed is a kind of multiple modified derivatives of gelatin having not only the structure of formula (I) but also one of structures of formula (II), (III), and (IV) as well. Wherein, G refers to gelatin residue comprising type A, type B and the type of gene recombination; R 1 refers to alkylene, or a linkage group with amide; R 2 refers to alkyl, or aryl; R 3 refers to alkylene; R 4 refers to carboxyl or carboxylate. The multiple modifying ways of gelatin comprise the hydrophobic modification on the amino group of gelatin through amide bond, carboxylation on the amino group of gelatin through amide bond, thiolation on the carboxyl group of gelatin, and thiolation following carboxylation on amino group of gelatin through amide bond. In addition, the invention also discloses the crosslinked material made of multiple modified derivatives of gelatin. The multiple modified derivatives of gelatin have flexible chemical structures and many properties. Their crosslinked gelatin material can be used the matrix for cell growth etc.
• BIOCOMPATIBLE RAPID-GELATING HYDROGEL AND ASSOCIATED PREPARATION METHOD OF SPRAY
  申请人：Shu Xiaozheng

  公开号：US20100144902A1

  公开（公告）日：2010-06-10

  This invention discloses a preparation method for biocompatible rapid-gelating hydrogel. Wherein, hydrogel is formed by rapid chemical-crosslinking using the mixing and chemical-crosslinking reaction under specified conditions between several active compound components. The preparation method comprises the following steps: (1) The solution containing biocompatible thiolated macromolecular derivatives (component A) and biocompatible thiol reactive crosslinking agents (component B) mutually mix to form reactive mixture with specified crosslinking conditions; (2) the reactive mixture forms the hydrogel. The invention also discloses a preparation method for novel rapid-gelating hydrogel spray and an application in medical field. This invention has the advantages of good biocompatibility, no by-products, good stability, convenient use, small amount of raw materials used, suitable for many medical application, etc.
• THIOL-MODIFIED MACROMOLECULE DERIVATIVES AND CROSS-LINKED MATERIALS THEREOF
  申请人：Song Chan

  公开号：US20100152423A1

  公开（公告）日：2010-06-17

  The disclosed is thiol-modified macromolecule derivatives having the general formula of (I) or (II), as well as the disulfide bond cross-linked materials and the thiol-reactive crosslinker cross-linked materials, wherein R 1 and R 2 are alkylene groups, substituted alkylene groups, aromatic groups or polyether groups and the like, respectively. R 1 and R 2 may have same or different chemical structure, and P is a residue of a macromolecule with side carboxyl group. The thiol-modified macromolecule derivative has a molecular weight of from 1000 to 5,000,000. The thiol-modified macromolecule derivative having the general formula of (I) or (II) of the present invention has a side chain with flexible chemical structure and adjustable properties, and has a number of advantages, such as mild reaction condition, high production yield, high degree of modifying, and the controllable modifying degree and so on. The cross-linked material made from the thiol-modified macromolecule derivative of the present invention can be used to inhibit cell attachment and be used as the matrix for cell attachment growth.
• US8158754B2
  申请人：——

  公开号：US8158754B2

  公开（公告）日：2012-04-17
• US8647670B2
  申请人：——

  公开号：US8647670B2

  公开（公告）日：2014-02-11