(2Z,4E,6S,7S,9S,10Z,12S,13R,14S,16R)-methyl 7,9,13-tris(tert-butyldimethylsilyloxy)-17-hydroxy-6,12,14,16-tetramethylheptadeca-2,4,10-trienoate | 1075200-51-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (2Z,4E,6S,7S,9S,10Z,12S,13R,14S,16R)-methyl 7,9,13-tris(tert-butyldimethylsilyloxy)-17-hydroxy-6,12,14,16-tetramethylheptadeca-2,4,10-trienoate
• 英文别名: methyl (2Z,4E,6S,7S,9S,10Z,12S,13R,14S,16R)-7,9,13-tris[[tert-butyl(dimethyl)silyl]oxy]-17-hydroxy-6,12,14,16-tetramethylheptadeca-2,4,10-trienoate
• CAS: 1075200-51-9
• 化学式: C₄₀H₈₀O₆Si₃
• 分子量: 741.328
• InChiKey: QEHRAZDRALKKEJ-QGBLFFLISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.32
• 重原子数：
  49
• 可旋转键数：
  23
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  74.2
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (2Z,4E,6S,7S,9S,10Z,12S,13R,14S,16R)-methyl 7,9,13-tris(tert-butyldimethylsilyloxy)-17-hydroxy-6,12,14,16-tetramethylheptadeca-2,4,10-trienoate 在 戴斯-马丁氧化剂 作用下， 以 二氯甲烷 为溶剂， 生成 methyl (2Z,4E,6S,7S,9S,10Z,12S,13R,14S,16R)-7,9,13-tris[[tert-butyl(dimethyl)silyl]oxy]-6,12,14,16-tetramethyl-17-oxoheptadeca-2,4,10-trienoate
  参考文献：
  名称：

  Improved Synthesis of 6-epi-Dictyostatin and Antitumor Efficacy in Mice Bearing MDA-MB231 Human Breast Cancer Xenografts

  摘要：

  Structure-activity Studies centered oil the naturally occurring antitumor agent dictyostatin have recently identified several highly active epimers and analogues. From these compounds, 6-epi-dictyostatin was selected for scaleup preparation and evaluation in animals. Here we describe a new total synthesis that produced more than 30 mg of 6-epi-diclyostatin. The compound was found to have potent antitumor activity in SCID mice bearing MDA-MB231 human breast cancer xenografts.

  DOI：

  10.1021/jm800979v
• 作为产物：
  描述：

  (2Z,4E,6S,7S,9S,10Z,12S,13R,14S,16R)-methyl 7,9,13-tris(tert-butyldimethylsilyloxy)-17-(4-methoxybenzyloxy)-6,12,14,16-tetramethylheptadeca-2,4,10-trienoate 在 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 二氯甲烷 为溶剂， 反应 1.5h， 以73%的产率得到(2Z,4E,6S,7S,9S,10Z,12S,13R,14S,16R)-methyl 7,9,13-tris(tert-butyldimethylsilyloxy)-17-hydroxy-6,12,14,16-tetramethylheptadeca-2,4,10-trienoate
  参考文献：
  名称：

  Improved Synthesis of 6-epi-Dictyostatin and Antitumor Efficacy in Mice Bearing MDA-MB231 Human Breast Cancer Xenografts

  摘要：

  Structure-activity Studies centered oil the naturally occurring antitumor agent dictyostatin have recently identified several highly active epimers and analogues. From these compounds, 6-epi-dictyostatin was selected for scaleup preparation and evaluation in animals. Here we describe a new total synthesis that produced more than 30 mg of 6-epi-diclyostatin. The compound was found to have potent antitumor activity in SCID mice bearing MDA-MB231 human breast cancer xenografts.

  DOI：

  10.1021/jm800979v

文献信息

• Improved Synthesis of 6-<i>epi</i>-Dictyostatin and Antitumor Efficacy in Mice Bearing MDA-MB231 Human Breast Cancer Xenografts
  作者：Julie L. Eiseman、Lihua Bai、Won-Hyuk Jung、Gustavo Moura-Letts、Billy W. Day、Dennis P. Curran

  DOI：10.1021/jm800979v

  日期：2008.11.13

  Structure-activity Studies centered oil the naturally occurring antitumor agent dictyostatin have recently identified several highly active epimers and analogues. From these compounds, 6-epi-dictyostatin was selected for scaleup preparation and evaluation in animals. Here we describe a new total synthesis that produced more than 30 mg of 6-epi-diclyostatin. The compound was found to have potent antitumor activity in SCID mice bearing MDA-MB231 human breast cancer xenografts.