(2S,6S)-6-(methanesulfonyloxymethyl)-4-(4-methoxybenzyl)morpholine-2-carboxylic acid 4-methoxybenzylamide | 1099828-13-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: (2S,6S)-6-(methanesulfonyloxymethyl)-4-(4-methoxybenzyl)morpholine-2-carboxylic acid 4-methoxybenzylamide
• 英文别名: [(2S,6S)-4-[(4-methoxyphenyl)methyl]-6-[(4-methoxyphenyl)methylcarbamoyl]morpholin-2-yl]methyl methanesulfonate
• CAS: 1099828-13-3
• 化学式: C₂₃H₃₀N₂O₇S
• 分子量: 478.566
• InChiKey: MZHRPRMUJIERAM-VXKWHMMOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  33
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  112
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  (2S,6S)-6-(methanesulfonyloxymethyl)-4-(4-methoxybenzyl)morpholine-2-carboxylic acid 4-methoxybenzylamide 在 potassium tert-butylate 作用下， 以 甲苯 、 叔丁醇 为溶剂， 反应 19.0h， 以92%的产率得到(1R,5S)-3,7-bis(4-methoxybenzyl)-9-oxa-3,7-diazabicyclo[3.3.1]nonan-2-one
  参考文献：
  名称：

  A Flexible Route to Chiral 2-endo-Substituted 9-Oxabispidines and Their Application in the Enantioselective Oxidation of Secondary Alcohols

  摘要：

  A new and flexible route to enantiomerically pure bi- and tricyclic 9-oxabispidines has been developed with use of (1R,5S)-7-methyl-2-oxo-9-oxa-3,7-diazabicyclo[3.3.1]nonane-3-carboxylic acid tert-butyl ester as the common late-stage intermediate. The 9-oxabispidines synthesized were evaluated as the chiral ligands in the Pd(II)-catalyzed oxidative kinetic resolution of secondary alcohols giving good to excellent selectivity factors of up to 19.

  DOI：

  10.1021/jo802409x
• 作为产物：
  描述：

  左旋环氧氯丙烷 、 2-hydroxy-N-(4-methoxybenzyl)-3-(4-methoxybenzylamino)propionamide 、 甲基磺酰氯 在 lithium perchlorate 、 potassium tert-butylate 、 三乙胺 作用下， 以 甲苯 、 叔丁醇 为溶剂， 反应 44.0h， 以16%的产率得到(2R,6S)-6-(methanesulfonyloxymethyl)-4-(4-methoxybenzyl)morpholine-2-carboxylic acid 4-methoxybenzylamide
  参考文献：
  名称：

  A Flexible Route to Chiral 2-endo-Substituted 9-Oxabispidines and Their Application in the Enantioselective Oxidation of Secondary Alcohols

  摘要：

  A new and flexible route to enantiomerically pure bi- and tricyclic 9-oxabispidines has been developed with use of (1R,5S)-7-methyl-2-oxo-9-oxa-3,7-diazabicyclo[3.3.1]nonane-3-carboxylic acid tert-butyl ester as the common late-stage intermediate. The 9-oxabispidines synthesized were evaluated as the chiral ligands in the Pd(II)-catalyzed oxidative kinetic resolution of secondary alcohols giving good to excellent selectivity factors of up to 19.

  DOI：

  10.1021/jo802409x

文献信息

• A Flexible Route to Chiral 2-<i>endo</i>-Substituted 9-Oxabispidines and Their Application in the Enantioselective Oxidation of Secondary Alcohols
  作者：Matthias Breuning、Melanie Steiner、Christian Mehler、Alexander Paasche、David Hein

  DOI：10.1021/jo802409x

  日期：2009.2.6

  A new and flexible route to enantiomerically pure bi- and tricyclic 9-oxabispidines has been developed with use of (1R,5S)-7-methyl-2-oxo-9-oxa-3,7-diazabicyclo[3.3.1]nonane-3-carboxylic acid tert-butyl ester as the common late-stage intermediate. The 9-oxabispidines synthesized were evaluated as the chiral ligands in the Pd(II)-catalyzed oxidative kinetic resolution of secondary alcohols giving good to excellent selectivity factors of up to 19.