N-Cyclopropyl Methyl Bimatoprost | 1138395-10-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-Cyclopropyl Methyl Bimatoprost
• 英文别名: (Z)-N-(cyclopropylmethyl)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]hept-5-enamide
• CAS: 1138395-10-4
• 化学式: C₂₇H₃₉NO₄
• 分子量: 441.6
• InChiKey: IBUQJJFOXZIFFM-SKHQJWOMSA-N

物化性质

• 溶解度：
  乙腈：3mg/mL； DMF：25mg/mL； DMSO：25mg/mL；乙醇：50mg/mL； PBS（pH 7.2）：0.25 mg/mL

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  32
• 可旋转键数：
  13
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  89.8
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• Prostaglandin Analog Compositions And Methods To Treat Epithelial-Related Conditions
  申请人：Lipkin Pamela

  公开号：US20090111761A1

  公开（公告）日：2009-04-30

  The present invention relates to the formulation and delivery of prostaglandin analogs to treat epithelial-related condition. In some embodiments, the compositions of the invention are used to stimulate hair growth. In some embodiments, the compositions of the invention are used to restore hair color to depigmented hair. The present invention further relates to the formulation and delivery of prostaglandin analogs to reduce intraocular pressure.
• PROSTAGLANDIN ANALOG COMPOSITIONS AND METHODS TO TREAT EPITHELIAL-RELATED CONDITIONS
  申请人：Lipkin Pamela

  公开号：US20090111882A1

  公开（公告）日：2009-04-30

  The present invention relates to the formulation and delivery of prostaglandin analogs to treat epithelial-related condition. In some embodiments, the compositions of the invention are used to stimulate hair growth. In some embodiments, the compositions of the invention are used to restore hair color to depigmented hair.
• Prostaglandin Analog Compositions To Treat Epithelial-Related Conditions
  申请人：Lipkin Pamela

  公开号：US20090111885A1

  公开（公告）日：2009-04-30

  The present invention relates to the formulation and delivery of prostaglandin analogs to treat epithelial-related condition. In some embodiments, the compositions of the invention are used to stimulate hair growth. In some embodiments, the compositions of the invention are used to restore hair color to depigmented hair.
• COMPOSITIONS AND METHODS TO TREAT EPITHELIAL-RELATED CONDITIONS
  申请人：Lipkin Pamela

  公开号：US20100074857A1

  公开（公告）日：2010-03-25

  The described invention relates to the formulation and delivery of compositions to treat an epithelial-related condition selected from the group consisting of sparse hair growth, short hair growth, thin hair growth, alopecia and hair depigmentation and methods for their use. In some embodiments, the composition contains a first component and a second component wherein the first component is at least one prostaglandin analog and the second component is at least one imidazole analog, such that the at least one imidazole analog improves the efficacy of the at least one prostaglandin analog when delivered to a subject refractory to the effect of the prostaglandin analog alone.
• METHODS TO PREVENT A HAIR-RELATED SIDE EFFECT OF TREATMENT WITH A CHEMOTHERAPEUTIC AGENT
  申请人：Lubit Beverly W.

  公开号：US20110002866A1

  公开（公告）日：2011-01-06

  The described invention relates to delivery of compositions comprising at least one prostaglandin analog to prevent or reduce hair loss (e.g. brittle hair growth, thin hair growth, short hair growth, sparse hair growth) or alopecia associated with chemotherapy.