代谢
老鼠代谢静脉注射的(14)C-标记的七氯成为环氧(在组织、粪便和尿液中发现)以及4,5,6,7,8,8-六氯-1-外羟基-6,7-外环氧-1,2,3A,4,7,7A-六氢-1,4-内亚甲基茚...这种亲水性代谢物通过尿液排出。在兔子中,放射性标记主要在尿液中发现(20%环氧,80%亲水性代谢物)。从连续30天喂食每千克饮食10毫克七氯环氧的大鼠粪便中分离出另一种粪便代谢物(1-羟基-2,3-环氧氯二烯的一种脱氢衍生物)。
RATS METABOLIZE IV ADMINISTERED (14)C-LABELED HEPTACHLOR TO THE EPOXIDE (FOUND IN TISSUES, FECES & URINE) & TO 4,5,6,7,8,8-HEXACHLORO-1-EXO-HYDROXY-6,7-EXO-EPOXY-1,2,3A,4,7,7A-HEXAHYDRO- 1,4-ENDO-METHYLENEINDENE ... A HYDROPHILIC METABOLITE WHICH IS EXCRETED IN THE URINE. IN RABBITS, THE RADIOACTIVE LABEL WAS FOUND MAINLY IN THE URINE (20% EPOXIDE, 80% HYDROPHILIC METABOLITE). ANOTHER FECAL METABOLITE (A DEHYDROGENATED DERIVATIVE OF 1-HYDROXY-2,3-EPOXYCHLORDENE) WAS ISOLATED FROM RATS FED 10 MG/KG DIET HEPTACHLOR EPOXIDE FOR 30 DAYS.
来源:Hazardous Substances Data Bank (HSDB)