N-(3-(1H-imidazol-1-yl)propyl)-1-(4-methoxyphenyl)cyclohexanecarbothioamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N-(3-(1H-imidazol-1-yl)propyl)-1-(4-methoxyphenyl)cyclohexanecarbothioamide
• 英文别名: Thioamide deriv. 77；N-(3-imidazol-1-ylpropyl)-1-(4-methoxyphenyl)cyclohexane-1-carbothioamide
• 化学式: C₂₀H₂₇N₃OS
• 分子量: 357.52
• InChiKey: AAMLNDSVOCHPQU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  71.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-(3-氨基丙基)咪唑 在 劳森试剂 、 三乙胺 作用下， 以 1,4-二氧六环 、 二氯甲烷 为溶剂， 反应 8.0h， 生成 N-(3-(1H-imidazol-1-yl)propyl)-1-(4-methoxyphenyl)cyclohexanecarbothioamide
  参考文献：
  名称：

  The First Potent Inhibitors for Human Glutaminyl Cyclase:  Synthesis and Structure−Activity Relationship

  摘要：

  The first effective inhibitors for human glutaminyl cyclase (QC) are described. The structures are developed by applying a ligand-based optimization approach starting from imidazole. Screening of derivatives of that heterocycle led to compounds of the imidazol-1-yl-alkyl thiourea type as a lead scaffold. A library of thiourea derivatives was synthesized, resulting in an inhibitory improvement by 2 orders of magnitude, leading to 1-(3-(1H-imidazol-1-yl)propyl)-3-(3,4-dimethoxyphenyl)thiourea as a potent inhibitor. Systematic exploitation of the scaffold revealed a strong impact on the inhibitory efficacy and resulted in the development of imidazole-propyl-thioamides as another new class of potent inhibitors. A flexible alignment of the most potent compounds of the thioamide and thiourea class and a QC substrate revealed a good match of characteristic features of the molecules, which suggests a similar binding mode of both inhibitors and the substrate to the active site of QC.

  DOI：

  10.1021/jm050756e

文献信息

• NOVEL GENES RELATED TO GLUTAMINYL CYCLASE
  申请人：Schilling Stephan

  公开号：US20080249083A1

  公开（公告）日：2008-10-09

  Novel glutaminyl-peptide cyclotransferase-like proteins (QPCTLs), which are isoenzymes of glutaminyl cyclase (QC, EC 2.3.2.5), and to isolated nucleic acids coding for these isoenzymes, all of which are useful for the discovery of new therapeutic agents, for measuring cyclase activity, and for determining the inhibitory activity of compounds against these glutaminyl cyclase isoenzymes.

  小说谷氨酰肽环转移酶样蛋白（QPCTLs），它们是谷氨酰环化酶（QC，EC 2.3.2.5）的同工酶，以及编码这些同工酶的分离核酸，所有这些对于发现新的治疗药物、测量环化酶活性以及确定化合物对这些谷氨酰环化酶同工酶的抑制活性都是有用的。
• Novel inhibitors of glutaminyl cyclase
  申请人：Schilling Stephan

  公开号：US20050215573A1

  公开（公告）日：2005-09-29

  The present invention relates to novel inhibitors of glutaminyl cyclase and combinations thereof for the treatment of neuronal disorders, especially Alzheimer's disease, Down Syndrome, Parkinson disease, Chorea Huntington, pathogenic psychotic conditions, schizophrenia, impaired food intake, sleep-wakefulness, impaired homeostatic regulation of energy metabolism, impaired autonomic function, impaired hormonal balance, impaired regulation, body fluids, hypertension, fever, sleep dysregulation, anorexia, anxiety related disorders including depression, seizures including epilepsy, drug withdrawal and alcoholism, neurodegenerative disorders including cognitive dysfunction and dementia.

  本发明涉及新型谷氨酰环化酶抑制剂及其组合物，用于治疗神经系统疾病，特别是阿尔茨海默病、唐氏综合征、帕金森病、亨廷顿舞蹈症、致病性精神病症、精神分裂症、食欲受损、睡眠-觉醒、体内能量代谢的失衡、自主神经功能受损、激素平衡受损、调节失调、体液平衡、高血压、发热、睡眠失调、厌食症、焦虑相关疾病包括抑郁症、癫痫发作包括癫痫、药物戒断和酗酒、神经退行性疾病包括认知功能障碍和痴呆症。
• New use of glutaminyl cyclase inhibitors
  申请人：Probiodrug AG

  公开号：EP2481408A2

  公开（公告）日：2012-08-01

  The present invention relates in general to an inhibitor of a glutaminyl peptide cyclotransferase, and use thereof for the treatment and/or prevention of a disease or disorder selected from the group consisting of inflammatory diseases selected from a. neurodegenerative diseases, e.g. mild cognitive impairment (MCI), Alzheimer's disease, neurodegeneration in Down Syndrome, Familial British Dementia, Familial Danish Dementia, multiple sclerosis, b. chronic and acute inflammations, e.g. rheumatoid arthritis, atherosclerosis, restenosis, pancreatitis, c. fibrosis, e.g. lung fibrosis, liver fibrosis, renal fibrosis, d. cancer, e.g. cancer/hemangioendothelioma proliferation, gastric carcinomas, e. metabolic diseases, e.g. hypertension, f. and other inflammatory diseases, e.g. neuropathic pain, graft rejection/graft failure/graft vasculopathy, HIV infections/AIDS, gestosis, tuberous sclerosis. Further, the invention relates to a respective diagnostic method, assay and kit.

  本发明总体上涉及谷氨酰胺肽环转酶的抑制剂，以及将其用于治疗和/或预防选 自以下一组炎症性疾病的疾病或紊乱 a. 神经退行性疾病，例如轻度认知障碍（MCI）、阿尔茨海默病、唐氏综合征的神经退行性疾病、家族性英国痴呆症、家族性丹麦痴呆症、多发性硬化症、 b. 慢性和急性炎症，如类风湿性关节炎、动脉粥样硬化、血管再狭窄、胰腺炎、 c. 纤维化，如肺纤维化、肝纤维化、肾纤维化、 d. 癌症，如癌症/血管内皮瘤增生、胃癌、 e. 代谢性疾病，如高血压、 f. 其他炎症性疾病，如神经性疼痛、移植物排斥/移植物失败/移植物血管病变、艾滋病病毒感染/艾滋病、妊娠中毒症、结节性硬化症。 此外，本发明还涉及一种相应的诊断方法、检测方法和试剂盒。
• Novel genes related to glutaminyl cyclase
  申请人：Probiodrug AG

  公开号：EP2581449A2

  公开（公告）日：2013-04-17

  The present invention relates to novel glutaminyl-peptide cyclotransferase-like proteins (QPCTLs), which are isoenzymes of glutaminyl cyclase (QC, EC 2.3.2.5), and to isolated nucleic acids coding for these isoenzymes, all of which are useful for the discovery of new therapeutic agents, for measuring cyclase activity, and for determining the inhibitory activity of compounds against these glutaminyl cyclase isoenzymes.

  本发明涉及新型谷氨酰胺基肽环转酶样蛋白（QPCTLs），它们是谷氨酰胺基环酶的同工酶（QC，EC 2.3.2.5），还涉及为这些同工酶编码的分离核酸，所有这些都有助于发现新的治疗药物、测量环酶活性以及确定化合物对这些谷氨酰胺基环酶同工酶的抑制活性。
• NOVEL INHIBITORS OF GLUTAMINYL CYCLASE
  申请人：Probiodrug AG

  公开号：EP1713780B1

  公开（公告）日：2012-01-18