三(2,4-二甲基苯基)磷化氢-5,5',5''-三磺酸三钠盐 | 443150-11-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 三(2,4-二甲基苯基)磷化氢-5,5',5''-三磺酸三钠盐
• 中文别名: 三(2,4-二甲基苯基)磷化氢-5,5',5''-三磺酸三钠盐,97%
• 英文名称: Txpts
• 英文别名: trisodium;5-bis(2,4-dimethyl-5-sulfonatophenyl)phosphanyl-2,4-dimethylbenzenesulfonate
• CAS: 443150-11-6
• 化学式: C24H24Na3O9PS3
• 分子量: 652.6
• InChiKey: YVYHEZNITVEWDK-UHFFFAOYSA-K

物化性质

• 熔点：
  >300°C
• 稳定性/保质期：
  按规定使用和贮存，该物质不会分解。应避免与氧化剂、水接触。

计算性质

• 辛醇/水分配系数(LogP)：
  -6.98
• 重原子数：
  40
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  197
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  N-[(1R)-1-(5-bromopyridin-2-yl)ethyl]-2-[4-(5-methylisoxazol-4-yl)phenyl]acetamide 、 乙烯基硼酸频哪醇酯 、 三(2,4-二甲基苯基)磷化氢-5,5',5''-三磺酸三钠盐 、 二异丙胺 在 醋酸钯 二氯甲烷 、 Brine 、 NaSO4 、 silica gel 、 乙酸乙酯 、 正己烷 作用下， 以 乙腈 、 水 为溶剂， 反应 0.33h， 以afforded 2-[4-(5-methylisoxazol-4-yl)phenyl]-N-[(1R)-1-(5-vinylpyridin-2-yl)ethyl]acetamide的产率得到2-[4-(5-methylisoxazol-4-yl)phenyl]-N-[(1R)-1-(5-vinylpyridin-2-yl)ethyl]acetamide
  参考文献：
  名称：

  Pyridyl Amide T-Type Calcium Channel Antagonists

  摘要：

  本发明涉及对T型钙通道具有拮抗作用的吡啶酰胺化合物，其在治疗或预防与T型钙通道有关的疾病和疾病中具有用途。本发明还涉及包含这些化合物的制药组合物以及使用这些化合物和组合物预防或治疗与T型钙通道有关的疾病的用途。

  公开号：

  US20090275550A1

文献信息

• Pyridyl Amide T-Type Calcium Channel Antagonists
  申请人：Barrow James C.

  公开号：US20090275550A1

  公开（公告）日：2009-11-05

  The present invention is directed to pyridyl amide compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.

  本发明涉及对T型钙通道具有拮抗作用的吡啶酰胺化合物，其在治疗或预防与T型钙通道有关的疾病和疾病中具有用途。本发明还涉及包含这些化合物的制药组合物以及使用这些化合物和组合物预防或治疗与T型钙通道有关的疾病的用途。
• MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS
  申请人：Combs Andrew Paul

  公开号：US20090286778A1

  公开（公告）日：2009-11-19

  The present invention relates to macrocyclic compounds of Formula I: or pharmaceutically acceptable salts thereof or quaternary ammonium salts thereof wherein constituent members are provided hereinwith, as well as their compositions and methods of use, which are JAK/ALK inhibitors useful in the treatment of JAK/ALK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.

  本发明涉及公式I的大环化合物，或其药学上可接受的盐或季铵盐，其中构成成员在此提供，以及它们的组合物和使用方法，它们是JAK / ALK抑制剂，可用于治疗JAK / ALK相关疾病，包括例如炎症和自身免疫性疾病以及癌症。
• Macrocyclic compounds and their use as kinase inhibitors
  申请人：Combs Andrew Paul

  公开号：US08871753B2

  公开（公告）日：2014-10-28

  The present invention relates to macrocyclic compounds of Formula I: or pharmaceutically acceptable salts thereof or quaternary ammonium salts thereof wherein constituent members are provided hereinwith, as well as their compositions and methods of use, which are JAK/ALK inhibitors useful in the treatment of JAK/ALK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.

  本发明涉及公式I的大环化合物，其药学上可接受的盐或季铵盐，其中组成成分在此提供，以及它们的组合物和使用方法，它们是JAK/ALK抑制剂，对于治疗JAK/ALK相关疾病，包括炎症和自身免疫性疾病以及癌症有用。
• METAL CHELATE COMPOUNDS FOR BINDING TO THE PLATELET SPECIFIC GLYCOPROTEIN IIB/IIIA
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US20160008490A1

  公开（公告）日：2016-01-14

  The present invention is directed to compounds that bind to glycoprotein IIb/IIIa and can be used for diagnostic imaging, in particular magnetic resonance imaging of thrombi. The disclosed compounds enable the binding to glycoprotein IIb/IIIa receptor combined with an adequate relaxivity.

  本发明涉及一种与糖蛋白IIb/IIIa结合的化合物，可用于诊断成像，特别是血栓的磁共振成像。所披露的化合物使得与糖蛋白IIb/IIIa受体的结合与适当的松弛度相结合。
• Pyridyl amide T-type calcium channel antagonists
  申请人：Merck Sharp & Dohme Corp.

  公开号：US07875636B2

  公开（公告）日：2011-01-25

  The present invention is directed to pyridyl amide compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.

  本发明涉及吡啶酰胺类化合物，其是T型钙通道的拮抗剂，适用于治疗或预防涉及T型钙通道的疾病和疾病。本发明还涉及包含这些化合物的药物组合物以及在预防或治疗涉及T型钙通道的疾病中使用这些化合物和组合物。