6-[(N-succinimidyl)oxy]-6-oxyhexyl(trimethyl)ammonium bromide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 6-[(N-succinimidyl)oxy]-6-oxyhexyl(trimethyl)ammonium bromide
• 英文别名: [6-(2,5-Dioxopyrrolidin-1-yl)oxy-6-oxohexyl]-trimethylazanium;bromide；[6-(2,5-dioxopyrrolidin-1-yl)oxy-6-oxohexyl]-trimethylazanium;bromide
• 化学式: Br*C₁₃H₂₃N₂O₄
• 分子量: 351.241
• InChiKey: ABAKXBQUMIDTLY-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.14
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  63.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  6-溴己酸N-羟基琥珀酰亚胺酯 、 三甲胺 以 四氢呋喃 为溶剂， 反应 12.0h， 以84%的产率得到6-[(N-succinimidyl)oxy]-6-oxyhexyl(trimethyl)ammonium bromide
  参考文献：
  名称：

  Rapid mass spectrometric identification of human genomic polymorphisms using multiplexed photocleavable mass-tagged probes and solid phase capture

  摘要：

  报告采用一种质谱方法，可同时快速检测多个单核苷酸多态性（SNPs）。寡核苷酸单碱基延伸（SBE）引物的 5′端标记有可光裂解、季铵化和溴化的肽质量标签，由四种双脱氧核苷酸的混合物延伸，其中一种是生物素化的。链霉亲和素涂层固相磁珠可捕获 3′-生物素化的延伸产物，而非生物素化的延伸产物和未反应的引物则会被洗去。在基质辅助激光解吸/电离飞行时间质谱（MALDI-TOF）分析过程中，从捕获的延伸产物中裂解出的季铵化和溴化质量标签可在 pmol 水平上进行检测。该方法被应用于线粒体 DNA 多态性分析，以实现人类身份识别的目的。

  DOI：

  10.1039/b704587e

文献信息

• PHOTO-ACTIVATED ATTACHMENT OF CHOLESTEROL TO POLYURETHANE SURFACES FOR ADHESION OF ENDOTHELIAL CELLS
  申请人：The Children's Hospital Of Philadelphia

  公开号：EP2416658A1

  公开（公告）日：2012-02-15
• Photo-Activated Attachment Of Cholesterol To Polyurethane Surfaces For Adhesion Of Endothelial Cells
  申请人：Levy Robert J.

  公开号：US20120089222A1

  公开（公告）日：2012-04-12

  A polymer is provided according to structure (I) wherein Y is a thiol-reactive group selected from one or more of the following moieties and Z is an ionogenic group selected from one or more of the following moieties. The surface of a polymeric substrate is modified by contacting the surface with a polymer according to structure II or structure III and exposing the surface to ultraviolet light.
• US8618242B2
  申请人：——

  公开号：US8618242B2

  公开（公告）日：2013-12-31
• [EN] PHOTO-ACTIVATED ATTACHMENT OF CHOLESTEROL TO POLYURETHANE SURFACES FOR ADHESION OF ENDOTHELIAL CELLS<br/>[FR] FIXATION PHOTOACTIVÉE DE CHOLESTÉROL À DES SURFACES DE POLYURÉTHANE POUR UNE ADHÉSION DE CELLULES ENDOTHÉLIALES
  申请人：PHILADELPHIA CHILDREN HOSPITAL

  公开号：WO2010118306A1

  公开（公告）日：2010-10-14

  A polymer is provided according to structure (I) wherein Y is a thiol-reactive group selected from one or more of the following moieties and Z is an ionogenic group selected from one or more of the following moieties. The surface of a polymeric substrate is modified by contacting the surface with a polymer according to structure II or structure III and exposing the surface to ultraviolet light.
• Rapid mass spectrometric identification of human genomic polymorphisms using multiplexed photocleavable mass-tagged probes and solid phase capture
  作者：Naomi Hammond、Peter Koumi、G. John Langley、Alex Lowe、Tom Brown

  DOI：10.1039/b704587e

  日期：——

  A mass spectrometric approach for rapid and simultaneous detection of several single nucleotide polymorphisms (SNPs) is reported. Oligonucleotide single base extension (SBE) primers, labelled at the 5′-end with photocleavable, quaternised and brominated peptidic mass tags, are extended by a mixture of the four dideoxynucleotides of which one is biotinylated. The 3′-biotinylated extension products are captured by streptavidin-coated solid phase magnetic beads, whilst non-biotinylated extension products and unreacted primers are washed away. Quaternised and brominated mass tags, cleaved from captured extension products during analysis by matrix-assisted laser desorption/ionisation-time-of-flight (MALDI-TOF) MS, are detected at pmol levels. This method is applied to the analysis of mitochondrial DNA polymorphisms for the purpose of human identification.

  报告采用一种质谱方法，可同时快速检测多个单核苷酸多态性（SNPs）。寡核苷酸单碱基延伸（SBE）引物的 5′端标记有可光裂解、季铵化和溴化的肽质量标签，由四种双脱氧核苷酸的混合物延伸，其中一种是生物素化的。链霉亲和素涂层固相磁珠可捕获 3′-生物素化的延伸产物，而非生物素化的延伸产物和未反应的引物则会被洗去。在基质辅助激光解吸/电离飞行时间质谱（MALDI-TOF）分析过程中，从捕获的延伸产物中裂解出的季铵化和溴化质量标签可在 pmol 水平上进行检测。该方法被应用于线粒体 DNA 多态性分析，以实现人类身份识别的目的。