N-(2-methoxy-phenyl)-N-nitroso-hydroxylamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-methoxy-phenyl)-N-nitroso-hydroxylamine
• 英文别名: N-(2-Methoxy-phenyl)-N-nitroso-hydroxylamin；2-Nitrosohydroxylamino-anisol；N-hydroxy-N-(2-methoxyphenyl)nitrous amide
• 化学式: C₇H₈N₂O₃
• 分子量: 168.152
• InChiKey: ACZRUGCLIOBJRJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.57
• 重原子数：
  12.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  62.13
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  2-硝基苯甲醚 、 亚硝酸异戊酯 在 ammonium hydroxide 、 锌 作用下， 生成 N-(2-methoxy-phenyl)-N-nitroso-hydroxylamine
  参考文献：
  名称：

  Baudisch; Rotschild, Chemische Berichte, 1915, vol. 48, p. 1663

  摘要：

  DOI：

文献信息

• TOPICAL DELIVERY OF A NITRIC OXIDE DONOR TO IMPROVE BODY AND SKIN APPEARANCE
  申请人：Strategic Science & Technologies, LLC

  公开号：EP1732577A2

  公开（公告）日：2006-12-20
• EP1732577A4
  申请人：——

  公开号：EP1732577A4

  公开（公告）日：2009-03-18
• Topical Delivery of a Nitric Oxide Donor to Improve and Skin Appearance
  申请人：Fossel Eric Thor

  公开号：US20080045909A1

  公开（公告）日：2008-02-21

  This invention generally relates to improvement of the body and skin appearance, for example enhancing the appearance of sagging, wrinkled, or cellulite-afflicted areas of the skin and body, through the local delivery of a nitric oxide donor, for example, using delivery vehicles such as lotions, creams, liquids, and/or transdermal patches. In some embodiments, a delivery vehicle containing a nitric oxide donor, for example, L-arginine (an important biological precursor) or its derivatives in a sufficient concentration to improve the appearance of a selected area of the body may be applied. In certain cases, one or more agents may also be included that aid in the transfer of the nitric oxide donor into the tissue, which may overcome the resistance to transfer into the skin. Non-limiting examples of suitable agents include agents able to create hostile biophysical environments, for instance, choline chloride, magnesium chloride, and/or sodium chloride.
• NITRIC OXIDE-RELEASING 3D-PRINTING COMPOSITIONS AND USES THEREOF
  申请人：Virginia Commonwealth University

  公开号：US20210301135A1

  公开（公告）日：2021-09-30

  A nitric oxide-releasing 3D printing ink is described for its composition and uses in fabricating a plurality of types of nitric oxide-releasing medical devices. The printing ink composition comprises a mixture of at least one nitric oxide donor and at least one polymer. The nitric oxide-releasing medical device is manufactured by 3D printing technology and provides antimicrobial and/or antithrombus effects by releasing nitric oxide in the presence of moisture.
• [EN] N-NITROSO-N-SUBSTITUTED HYDROXYLAMINES AS NITRIC OXIDE DONORS<br/>[FR] HYDROXYLAMINES N-NITROSO-N-SUBSTITUES UTILISES COMME DONNEURS D'OXYDE NITRIQUE
  申请人：BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

  公开号：WO1996036326A1

  公开（公告）日：1996-11-21

  (EN) Nitric oxide has proved to mediate many important physiological processes. The nitric oxide donors of the present invention have a NONOate anion linked to an $i(ortho)-substituted aryl, a heteroaromatic substituent, a steroid, or a catecholamine. Preferred $i(ortho) substituents are alkoxy, halo, and alkyl. The cation of the salt is an alkali metal, an alkaline-earth metal, an ammonium or substituted ammonium group. Nitric oxide donors provided herein are more stable than that of nitrogen-bonded NONOates described previously. The by-product left after release of NO, and the nitric oxide donors themselves, are very probably less carcinogenic than the corresponding nitrogen-bonded NONOates.(FR) L'oxyde nitrique s'est avéré induire de nombreux processus physiologiques importants. Les donneurs d'oxyde nitrique de la présente invention ont un anion NONOate lié à un aryle à substitution $i(ortho), un substituant hétéroaromatique, un stéroïde ou une catécholamine. Les substituants $i(ortho) préférés sont alcoxy, halo et alkyle. Le cation du sel est un métal alcalin, un métal alcalino-terreux, un groupe ammonium ou à substitution ammonium. Les donneurs d'oxyde nitrique de l'invention sont plus stables que ceux des NONOates liés à l'azote antérieurement décrits. Le sous-produit laissé après la libération de NO, et les donneurs d'oxyde nitrique eux-mêmes, sont très probablement moins cancérogènes que les NONOates correspondants liés à l'azote.