2-(1-ethyl-1-phenylpropyl)-4-(quinolin-2-ylmethoxy)phenoI

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(1-ethyl-1-phenylpropyl)-4-(quinolin-2-ylmethoxy)phenoI
• 英文别名: 2-(3-Phenylpentan-3-yl)-4-(quinolin-2-ylmethoxy)phenol
• 化学式: C₂₇H₂₇NO₂
• 分子量: 397.517
• InChiKey: AHIREVYLLCOZKX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  42.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(1-ethyl-1-phenylpropyl)-4-(quinolin-2-ylmethoxy)phenoI 在 吡啶 、 1,1'-双(二苯基膦)二茂铁 、 palladium diacetate 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 生成 methyl 2-(1-ethyl-1-phenylpropyl)-4-(quinolin-2-ylmethoxy)benzoate
  参考文献：
  名称：

  Evaluation of endo- and exo-aryl-substitutions and central scaffold modifications on diphenyl substituted alkanes as 5-lipoxygenase activating protein inhibitors

  摘要：

  A search for a suitable replacement for the central norbornyl scaffold presented in the recently disclosed novel FLAP inhibitors is herein described, as well as the SAR study performed on the endo and exo-aryl groups. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.04.064
• 作为产物：
  描述：

  2-(氯甲基)喹啉 在 甲醇 、 sodium hydride 、 potassium hydroxide 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 生成 2-(1-ethyl-1-phenylpropyl)-4-(quinolin-2-ylmethoxy)phenoI
  参考文献：
  名称：

  Evaluation of endo- and exo-aryl-substitutions and central scaffold modifications on diphenyl substituted alkanes as 5-lipoxygenase activating protein inhibitors

  摘要：

  A search for a suitable replacement for the central norbornyl scaffold presented in the recently disclosed novel FLAP inhibitors is herein described, as well as the SAR study performed on the endo and exo-aryl groups. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.04.064

文献信息

• Diphenylmethane Derivatives as Inhibitors of Leukotriene Biosynthesis
  申请人：Armstrong Helen M.

  公开号：US20090258885A1

  公开（公告）日：2009-10-15

  The instant invention provides compounds of Formula I which are 5-lipoxygenase activating protein inhibitors. Compounds of Formula I are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents.

  本发明提供了公式I的化合物，这些化合物是5-脂氧合酶活化蛋白抑制剂。公式I的化合物可用作抗动脉粥样硬化、抗哮喘、抗过敏、抗炎和细胞保护剂。
• WO2007/56210
  申请人：——

  公开号：——

  公开（公告）日：——
• [EN] DIPHENYLMETHANE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS<br/>[FR] DÉRIVÉS DE DIPHÉNYLMÉTHANE SERVANT D'INHIBITEURS DE LA BIOSYNTHÈSE DES LEUCOTRIÈNES
  申请人：MERCK & CO INC

  公开号：WO2007056210A2

  公开（公告）日：2007-05-18

  [EN] The instant invention provides compounds of Formula I which are 5-lipoxygenase activating protein inhibitors. Compounds of Formula I are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents.
  [FR] La présente invention concerne des composés de formule (I), lesquels sont des inhibiteurs de la protéine activant la 5-lipoxygénase. Les composés de formule I sont utiles comme agents anti-athéroscléreux, antiasthmatiques, antiallergiques, anti-inflammatoires et cytoprotecteurs.
• Evaluation of endo- and exo-aryl-substitutions and central scaffold modifications on diphenyl substituted alkanes as 5-lipoxygenase activating protein inhibitors
  作者：Lin Chu、Helen M. Armstrong、Linda L. Chang、Amy F. Cheng、Lawrence Colwell、Jisong Cui、Jilly Evans、Amy Galka、Mark T. Goulet、Nancy Hayes、Jane Lo、John Menke、Hyun O. Ok、Debra L. Ondeyka、Minal Patel、Grace M. Quaker、Heather Sings、Stephanie L. Witkin、Annie Zhao、Feroze Ujjainwalla

  DOI：10.1016/j.bmcl.2012.04.064

  日期：2012.6

  A search for a suitable replacement for the central norbornyl scaffold presented in the recently disclosed novel FLAP inhibitors is herein described, as well as the SAR study performed on the endo and exo-aryl groups. (C) 2012 Elsevier Ltd. All rights reserved.